|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
For these studies, MatLyLu rat prostate cancer cells were transfected with full-length cDNA encoding parathyroid hormone-related protein [PTHrP (MatLyLu-PTHrP cells)], which is known to be the major pathogenetic factor for malignancy-associated hypercalcemia.
|
12727822 |
2003 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Parathyroid hormone-related protein (PTHRP) is in part responsible for the clinical syndrome of hypercalcaemia of malignancy and has been implicated as an important factor in the development of bone metastases.
|
12374685 |
2002 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Humoral hypercalcemia of malignancy (HHM), a paraneoplastic syndrome associated with epithelial cancers, including squamous cell carcinoma (SCC), is due to expression and secretion of parathyroid hormone-related protein (PTHrP).
|
11911944 |
2002 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Parathyroid hormone-related protein (PTHrP), a factor responsible for malignancy associated hypercalcemia, plays a physiological roles such as bone development and placental calcium transport.
|
11813867 |
2002 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The SCID/beige mouse model mimics HHM as it occurs in ATL patients, and will be useful to investigate the regulation of PTHrP expression by ATL cells in vivo.
|
11395400 |
2001 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the present study, we have investigated vitamin D metabolism in our newly developed rat model of HHM in which a human infantile fibrosarcoma producing parathyroid hormone-related protein (PTHrP), named OMC-1, was inoculated s.c. into athymic nude rats.
|
11691644 |
2001 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recent studies have shown that a large number of prostate tumors demonstrate the presence of PTHrP despite the fact that prostate cancer is rarely associated with the HHM syndrome.
|
12230264 |
2001 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
In a model of humoral hypercalcemia of malignancy in which PTHrP secreted by s.c. xenografts of human lung cancer in nude mice induces extensive osteolysis and severe hypercalcemia, daily administration of muRANK.Fc from time of tumor implantation profoundly inhibited osteoclastic bone resorption and prevented hypercalcemia. muRANK.Fc had no effect on tumor production of PTHrP, because there was no significant difference between circulating human PTHrP levels in muRANK.Fc-treated and vehicle-treated tumor-bearing mice.
|
11289133 |
2001 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Humoral hypercalcemia of malignancy is believed to be induced when parathyroid hormone-related protein (PTHrP) is excessively produced in cancer cells and impairs the homeostasis of serum calcium concentrations.
|
11737483 |
2001 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Parathyroid hormone-related protein (PTHrP) is produced by various neoplasms and is known to be a causative factor of hypercalcemia of malignancy.
|
11029801 |
2000 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Parathyroid hormone-related protein (PTHrP) is the major mediator of the humoral hypercalcemia of malignancy and of malignant osteolysis associated with skeletal metastases of common epithelial cancers.
|
10942719 |
2000 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Humoral hypercalcaemia of malignancy (HHM) commonly results from the excessive production of a parathyroid hormone-related protein (PTHrP) by tumours.
|
11044652 |
2000 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Parathyroid hormone-related protein (PTHrP) was originally identified as the tumor factor responsible for a clinical syndrome known as humoral hypercalcemia of malignancy.
|
10219904 |
1999 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Parathyroid hormone-related protein (PTHrP) is a primary factor in the pathogenesis of malignancy-associated hypercalcemia.
|
9610565 |
1998 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Parathyroid-hormone-related protein (PTHrP) is the main mediator of the humoral hypercalcemia of malignancy.
|
9422518 |
1998 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Parathyroid hormone-related protein (PTHrP) is the cause of humoral hypercalcaemia of malignancy and interacts with parathyroid hormone (PTH) receptors.
|
9390035 |
1997 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
There appears to be little doubt that PTH-rP is the major mediator of hypercalcemia in patients with HHM, although it is possible that other factors (e.g., bone resorbing cytokines) also could contribute in some patients.
|
9362423 |
1997 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
PTHrP was the causative factor for HHM in this case.
|
9042805 |
1997 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
PTHrP gene amplification was also detected in one of five other tumors associated with humoral hypercalcemia of malignancy.
|
8768840 |
1996 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Parathyroid hormone-related protein (PTHrP), a major factor in the pathogenesis of humoral hypercalcemia of malignancy, is produced by many squamous carcinoma cells (SCCs).
|
8921834 |
1996 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although PTHrP was discovered because of its production by cancers, evidence for its actions as a local regulator highlights the importance of understanding its roles not only in the etiology of HHM in cancer patients but also in normal tissues.
|
7495499 |
1995 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Over the past decade, studies have shown that parathyroid hormone-related protein is the cause of the HHM syndrome, and recent data suggest that this protein may also play a paracrine role in some patients with local osteolytic hypercalcemia.
|
8198376 |
1994 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These results indicate that TGF-beta increased PTHrP production and mRNA expression in malignant keratinocytes and suggest that TGF-beta may be an important factor in the pathogenesis of humoral hypercalcemia of malignancy.
|
8194469 |
1994 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results confirmed that gynecological malignancies, although rarely associated with humoral hypercalcemia of malignancy (HHM), stained for PTHrP in a majority of the squamous-cell carcinomas (SCC) at all sites, but only in a minority of adenocarcinomas, and then in areas of squamous metaplasia.
|
8314318 |
1994 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Despite their high frequency of expression of PTHrP, cervical tumors seldom give rise to humoral hypercalcemia of malignancy, but the autocrine/paracrine effects of PTHrP may be important in the growth and dedifferentiation of the malignant cell population.
|
8004587 |
1994 |