|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
Minihepcidins are hepcidin agonists that have been previously shown to reverse iron overload and improve erythropoiesis in mice affected by non-transfusion dependent thalassemia.
|
31582543 |
2019 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
Furthermore, insufficiently elevated hepcidin occurs in multiple diseases associated with iron overload.
|
30798811 |
2019 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
Iron overload has been associated with oxidative stress, advanced fibrosis and decreased survival, and promising therapies beyond phlebotomy and oral iron chelation have included hepcidin agonists.
|
30761559 |
2019 |
|
Iron Overload
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Expression of hepcidin, the hormone regulating iron homeostasis, is increased by iron overload and decreased by accelerated erythropoiesis or iron deficiency.
|
30958854 |
2019 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
Erythroferrone-induced hepcidin suppression in diseases of expanded hematopoiesis results in iron overload.
|
31808893 |
2019 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
Iron overload in congenital haemolytic anaemias: role of hepcidin and cytokines and predictive value of ferritin and transferrin saturation.
|
30828802 |
2019 |
|
Iron Overload
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The bone morphogenetic protein (BMP)-SMAD signaling pathway is a key transcriptional regulator of hepcidin in response to tissue iron stores, serum iron, erythropoietic drive and inflammation to increase the iron supply when needed for erythropoiesis, but to prevent the toxicity of iron excess.
|
30478858 |
2019 |
|
Iron Overload
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Also, it disturbed the iron homeostasis through increasing C/EBP homologous protein (CHOP), decreasing phosphorylated cAMP responsive element binding protein(P-CREB) and hepcidin levels leading to significant serum and hepatic iron overload.
|
31499193 |
2019 |
|
Iron Overload
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Hyperlipidemia could cause iron overload in the aorta and increased serum hepcidin level, particularly in FPN1 Tek-cre mice, and can be reversed by TMP intervention.
|
29763925 |
2018 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results suggest that iron overload and hepcidin inadequacy existed in CP with T2DM patients.
|
29636044 |
2018 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
Iron overload (IOL) starts to develop in MDS patients before they become transfusion-dependent because ineffective erythropoiesis suppresses hepcidin production in the liver and thus leads to unrestrained intestinal iron uptake.
|
29177643 |
2018 |
|
Iron Overload
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Hepcidin, a liver-derived hormone, negatively regulates circulating iron levels through an increase in its expression in response to iron overload.
|
30269025 |
2018 |
|
Iron Overload
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Erythroblast-specific <i>Fpn</i> knockout (<i>Fpn</i> KO) mice developed lower serum iron levels in conjunction with tissue iron overload and increased FPN expression in spleen and liver without changing hepcidin levels.
|
30213870 |
2018 |
|
Iron Overload
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Treatment with PEP-fusion-recombinant-Prx2 (PEP Prx2) significantly increased STAT3 activation with upregulation of Hamp expression in both IO- and LPS-exposed Prx2<sup>-/-</sup> mice.
|
28793778 |
2018 |
|
Iron Overload
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In mice, hepatocyte-specific Alk2 deficiency leads to moderate iron overload with periportal liver iron accumulation, while hepatocyte-specific Alk3 deficiency leads to severe iron overload with centrilobular liver iron accumulation and a more marked reduction of basal hepcidin levels.
|
30227271 |
2018 |
|
Iron Overload
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Using independent small molecule inhibitors of the NFkB pathway, we demonstrate that inhibition of NFkB signaling causes induction of hepcidin transcription and reduction of iron overload in the HH3 model.
|
29897731 |
2018 |
|
Iron Overload
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Hepcidin induction by RNAi-mediated inhibition of TMPRSS6 expression reduces iron overload and mitigates anemia in murine models of β-thalassemia intermedia.
|
29498084 |
2018 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
The hepcidin/ferroportin system was used to classify genetic iron overload syndromes in Japan, and ceruloplasmin and ATP7B were introduced for subtyping Wilson disease into the severe hepatic and classical forms.
|
29882374 |
2018 |
|
Iron Overload
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Concurrently, there is a decrease in hepcidin expression and a subsequent state of iron overload.
|
29458727 |
2018 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
Hepcidin agonists also have the potential to prevent severe complications of siderophilic infections in patients with iron overload or chronic liver disease.
|
29523504 |
2018 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
Therefore, hepcidin and its associated signaling pathway proteins may represent potential targets for the treatment of conditions associated with iron overload.
|
29115497 |
2018 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
We tested 10 clinical isolates of <i>Escherichia coli</i> from children with sepsis and found that both genetic iron overload (by hepcidin-1 knockout [HKO]) and iatrogenic iron overload (by intravenous iron) potentiated infection with 8 out of the 10 studied isolates: after peritoneal injection of <i>E. coli</i>, iron-loaded mice developed sepsis with 60% to 100% mortality within 24 h, while control wild-type mice suffered 0% mortality.
|
29735522 |
2018 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
Iron-dependent hepcidin induction requires hemojuvelin (HJV), a bone morphogenetic protein (BMP) coreceptor that is disrupted in juvenile hemochromatosis, causing dramatic hepcidin deficiency and tissue iron overload.
|
30213871 |
2018 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
Contrasting with the aforementioned entities which involve compartmental, and sometimes, systemic iron excess, the iron refractory iron deficiency anemia (IRIDA) corresponds to a usually severe anemia with whole body iron deficiency related to chronic increase of plasma hepcidin, the systemic negative regulator of plasma iron.
|
30115430 |
2018 |
|
Iron Overload
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The hepcidin/ferritin ratio in thalassemic children was significantly lower (P<0.001) suggesting that hepcidin levels were not increased in proportion to the iron overload.
|
29941702 |
2018 |