HAMP, hepcidin antimicrobial peptide, 57817

N. diseases: 377; N. variants: 15
Disease: Iron Overload ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 AlteredExpression disease BEFREE We evaluated the effect of iron overload and of ineffective erythropoeisis on hepcidin expression in patients with thalassemia major. 16769583 2006
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 AlteredExpression disease BEFREE Hepcidin is the presumed negative regulator of systemic iron levels; its expression is induced in iron overload, infection, and inflammation, and by cytokines, but is suppressed in hypoxia and anemia. 16902156 2006
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 AlteredExpression disease BEFREE Our results suggest that, in beta-thalassaemia, serum factors might override the potential effect of iron overload on HAMP expression, thereby providing an explanation for the failure to arrest excessive intestinal iron absorption in these patients. 16939499 2006
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 AlteredExpression disease BEFREE Inappropriately low hepcidin levels cause iron overload, while increased hepcidin expression plays an important role in the anemia of inflammation (AI) by restricting intestinal iron absorption and macrophage iron release. 16946298 2007
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 Biomarker disease LHGDN [To prevent and cure the iron overloads, the hopes of hepcidin]. 16962038 2006
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 GeneticVariation disease BEFREE The simultaneous detection of 18 known HFE, TFR2 and FPN1 mutations and sequencing of the HAMP gene were performed to rule out the possible existence of genetic modifier factors related with iron overload. 17042772 2007
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 AlteredExpression disease BEFREE Individuals with pathogenic mutations in HFE, hemojuvelin (HJV) and transferrin receptor 2 (TfR2) have low levels of hepcidin, but little is known about the hepatic expression of these molecules in patients with physiological iron overload or HFE associated Hemochromatosis (HH). 17098454 2007
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 GeneticVariation disease BEFREE Hemojuvelin (HJV) positively modulates the iron regulator hepcidin, and its mutations are the major cause of juvenile hemochromatosis (JH), a recessive disease leading to iron overload. 17264300 2007
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 Biomarker disease BEFREE To elucidate the contribution of hepcidin toward the hepatic excess iron accumulation in ALD, we examined whether alcohol loading affects hepcidin expression both in ALD patients and in an ethanol-fed mouse model. 17331161 2007
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 GeneticVariation disease BEFREE The S338R mutation results in a mutated ferroportin associated with iron overload and is predicted insensitive to regulation by the iron regulatory hormone hepcidin. 17383046 2007
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 AlteredExpression disease BEFREE Mice with targeted disruption of the Hjv gene (Hjv-/- mice) fail to upregulate hepatic Hamp1 expression following iron overload. 17395503 2007
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 AlteredExpression disease BEFREE We assessed the degree of iron overload in thalassemia intermedia and major patients by measuring hepatic iron concentration in liver biopsy samples and serum ferritin, estimated erythropoietic drive by assaying soluble transferrin receptor and serum erythropoietin levels and correlated these with urinary hepcidin measurements. 17488680 2007
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 Biomarker disease BEFREE When adjusted by either serum ferritin values or hepatic iron scores, hepcidin indices were significantly lower in HCV(+) patients than in HBV(+) patients, suggesting that hepcidin may play a pivotal role in the pathogenesis of iron overload in patients with chronic hepatitis C. 17515961 2007
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 Biomarker disease BEFREE Hepcidin production is increased by iron overload and decreased by anemia and hypoxia; but the molecular mechanisms that govern the hepcidin response to these stimuli are not known. 17557118 2007
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 AlteredExpression disease BEFREE These results suggest that GDF15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression. 17721544 2007
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 AlteredExpression disease LHGDN These results suggest that GDF15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression. 17721544 2007
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 Biomarker disease BEFREE Inadequate hepcidin synthesis leads to iron overload in HFE-related hemochromatosis. 17724144 2007
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 Biomarker disease BEFREE Current thinking is that defective Hepcidin synthesis or defective iron-sensing mechanisms leading to Hepcidin deficiency is the cause of iron overload in HFE-Haemochromatosis. 18054440 2008
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 AlteredExpression disease BEFREE Aberrations in hepcidin expression or responsiveness to hepcidin result in disorders of iron deficiency and iron overload. 18282520 2008
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 AlteredExpression disease LHGDN No alterations in mRNA expression of either iron transporters or exporters were found in DHIO. mRNA and urinary hepcidin levels normalized for the amount of iron overload showed a significantly lower ratio than in controls, although not as low as in hemochromatosis or beta-thalassemia. 18462824 2008
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 AlteredExpression disease BEFREE No alterations in mRNA expression of either iron transporters or exporters were found in DHIO. mRNA and urinary hepcidin levels normalized for the amount of iron overload showed a significantly lower ratio than in controls, although not as low as in hemochromatosis or beta-thalassemia. 18462824 2008
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 Biomarker disease BEFREE The mRNA expression of the iron-regulatory peptide hepcidin was increased in NAFLD patients with iron overload, which was paralleled by low duodenal FP-1 expression. 18469261 2008
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 Biomarker disease BEFREE The aim of this study is to determine the clinical relevance of hepatic producing iron regulatory hormone-hepcidin, on iron overload in patients with chronic hepatitis C (CHC). 18620776 2008
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 AlteredExpression disease BEFREE Hepatic HAMP expression in patients with PCT was significantly reduced, regardless of HFE genotype, when compared with patients with hh but without PCT with comparable iron overload. 18809758 2008
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 AlteredExpression disease BEFREE Notably, Bmp6-null mice have a phenotype resembling hereditary hemochromatosis, with reduced hepcidin expression and tissue iron overload. 19252486 2009