|
Acute Promyelocytic Leukemia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Rap1GAP alters leukemia cell differentiation, apoptosis and invasion in vitro.
|
22614916 |
2012 |
|
Adenoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
To confirm the significance of these findings, we analyzed Rap1GAP expression in a larger set of benign tumors (adenomas and hyperplastic nodules) and PTCs.
|
19066305 |
2009 |
|
Alkaline phosphatase measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.
|
29403010 |
2018 |
|
Anaplastic thyroid carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
To explore the functional significance of RAP1GAP depletion, RAP1GAP was transiently expressed at the lowest level that is sufficient to block endogenous RAP2 activity in papillary and anaplastic thyroid carcinoma cell lines.
|
22696507 |
2012 |
|
Anaplastic thyroid carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Treatment with the structurally distinct histone deacetylase (HDAC) inhibitors, sodium butyrate and trichostatin A, increased Rap1GAP expression in all the differentiated thyroid carcinoma cell lines and in four of the six ATC cell lines.
|
21367844 |
2011 |
|
Behavioral variant of frontotemporal dementia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Real-time polymerase chain reaction (PCR) confirmed a significant decrease in leukocytes mRNA messenger RNA (mRNA) levels of RAP1GAP in bvFTD patients as compared with avPPA (p = 0.049).
|
24368088 |
2014 |
|
Benign Neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
To confirm the significance of these findings, we analyzed Rap1GAP expression in a larger set of benign tumors (adenomas and hyperplastic nodules) and PTCs.
|
19066305 |
2009 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
To investigate whether the Epac-Rap-RapGAP pathway could play a potential role in thyroid tumorigenesis, the mRNA expressions of its constituent proteins were investigated in two malignant thyroid tumor types.
|
22240166 |
2012 |
|
Carcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Previous findings indicate that Rap1GAP acts as a tumor suppressor inhibiting Ras superfamily protein Rap1 in multiple aggressive carcinomas; however, Rap1GAP expression in EAC has not been investigated.
|
28196746 |
2017 |
|
Childhood Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
In conclusion, these results demonstrated that Rap1GAP promoted leukemia cell differentiation and apoptosis, but increased leukemia cell invasion in vitro.
|
22614916 |
2012 |
|
Childhood Leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Several candidate genes which were differentially expressed in MDS patients versus normal controls were selected and confirmed in expanding samples by quantitative real-time reverse transcription-polymerase chain reaction after clustering and bioinformatics analysis. one of these genes, RAP1GAP, was found to be expressed at a significantly higher level in patients with MDS in comparison with those suffering from other hematopoietic diseases including leukemia (P < 0.01).
|
18551404 |
2008 |
|
Colorectal Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Decreased expression of Rap1GAP was significantly associated with depth of invasion, lymph node metastasis, advanced Tumor-Node-Metastasis stage and a poor prognosis in patients with CRC following surgery.
|
29725465 |
2018 |
|
Colorectal Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We show that Rap1GAP expression is decreased in primary colorectal carcinomas.
|
20439492 |
2010 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
RCC cell lines express distinct levels of cell adhesion proteins and the forced over-expression of Rap1GAP attenuated levels of both cadherins and integrins that are known to regulate the cancer cells invasion.
|
22266190 |
2012 |
|
Differentiated Thyroid Gland Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Treatment with the structurally distinct histone deacetylase (HDAC) inhibitors, sodium butyrate and trichostatin A, increased Rap1GAP expression in all the differentiated thyroid carcinoma cell lines and in four of the six ATC cell lines.
|
21367844 |
2011 |
|
Disease Exacerbation
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Rap1GAP alters leukemia cell differentiation, apoptosis and invasion in vitro.
|
22614916 |
2012 |
|
Endometrial Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Rap1GAP inhibits tumor progression in endometrial cancer.
|
28196746 |
2017 |
|
Familial multiple trichoepitheliomata
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Patients with higher Rap1GAP, E-cadherin, and especially combined Rap1GAP/E-cadherin levels had better overall survival than EAC patients with no or weak expression.
|
28196746 |
2017 |
|
Focal glomerulosclerosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Podocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis-associated glomerular injury.
|
24642466 |
2014 |
|
Frontotemporal Lobar Degeneration
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The alteration of RAP1GAP mRNA levels may explain the clinical variability of GRN-FTLD patients.
|
24368088 |
2014 |
|
Inorganic phosphate measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.
|
29403010 |
2018 |
|
Invasive Carcinoma
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Immunoblotting results show that Rap1Gap levels in MCF10.Ca1D cells (a model of invasive carcinoma) are reduced compared to those in MCF10.DCIS (a model of DCIS).
|
30144784 |
2018 |
|
Invasive carcinoma of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of Rap1Gap: A Switch from DCIS to Invasive Breast Carcinoma via ERK/MAPK Activation.
|
30144784 |
2018 |
|
Juvenile Myelomonocytic Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mutations of signal-induced proliferation-associated gene 1 (<i>SIPA1</i>), a RAP1 GTPase-activating protein, were reported in patients with juvenile myelomonocytic leukemia, a childhood myelodysplastic/myeloproliferative neoplasm (MDS/MPN).
|
29514790 |
2018 |
|
leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Several candidate genes which were differentially expressed in MDS patients versus normal controls were selected and confirmed in expanding samples by quantitative real-time reverse transcription-polymerase chain reaction after clustering and bioinformatics analysis. one of these genes, RAP1GAP, was found to be expressed at a significantly higher level in patients with MDS in comparison with those suffering from other hematopoietic diseases including leukemia (P < 0.01).
|
18551404 |
2008 |