|
Malignant neoplasm of breast
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
TUBEROUS SCLEROSIS 2 (disorder)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this study, we characterized the rat Tsc2 cDNA and found that it is highly homologous with the human gene, including a conserved rap1GAP catalytic domain.
|
8519695 |
1995 |
|
Tuberous Sclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Individuals with tuberous sclerosis complex (TSC) develop astrocytoma-like tumors resulting from mutations in the TSC2 protein, tuberin, which is hypothesized to function as a Rap1 GTPase activating protein (GAP).
|
12469204 |
2003 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The retrovirally tagged genes Plekhb1, Prex1, Prkg2, Sox10 and 1200004M23Rik were upregulated in the tumors but had a different expression profile than Pdgfralpha whereas Rap1gap, Gli1, Neurl and Camk2b were downregulated in the tumors.
|
15750623 |
2005 |
|
Malignant neoplasm of pancreas
|
0.330 |
Biomarker
|
disease |
BEFREE |
Collectively, our data identify rap1GAP as a putative tumor suppressor gene in pancreatic cancer.
|
16424023 |
2006 |
|
Pancreatic Neoplasm
|
0.310 |
Biomarker
|
disease |
LHGDN |
Identification of a putative tumor suppressor gene Rap1GAP in pancreatic cancer.
|
16424023 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, SCC cells transfected with rap1GAP produced significantly smaller tumors in nude mice as compared to controls (P < 0.01).
|
16436672 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Collectively, our data identify rap1GAP as a putative tumor suppressor gene in pancreatic cancer.
|
16424023 |
2006 |
|
Pancreatic carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Collectively, our data identify rap1GAP as a putative tumor suppressor gene in pancreatic cancer.
|
16424023 |
2006 |
|
Squamous cell carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The results demonstrate that expression of rap1GAP in oropharyngeal SCC down-regulated active rap1, ERK activation, and proliferation.
|
16436672 |
2006 |
|
Squamous cell carcinoma
|
0.020 |
AlteredExpression
|
disease |
LHGDN |
Furthermore, SCC cells transfected with rap1GAP produced significantly smaller tumors in nude mice as compared to controls (P < 0.01).
|
16436672 |
2006 |
|
Squamous cell carcinoma of oropharynx
|
0.010 |
Biomarker
|
disease |
BEFREE |
Rap1GAP inhibits tumor growth in oropharyngeal squamous cell carcinoma.
|
16436672 |
2006 |
|
Oropharyngeal disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The results demonstrate that expression of rap1GAP in oropharyngeal SCC down-regulated active rap1, ERK activation, and proliferation.
|
16436672 |
2006 |
|
Thyroid Neoplasm
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
In support of that notion, Rap1GAP was highly expressed in normal human thyroid cells and downregulated in primary thyroid tumors.
|
17646383 |
2007 |
|
Tumor Cell Invasion
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Collectively, these data implicate Rap1GAP as a putative tumor/invasion suppressor in the thyroid.
|
17646383 |
2007 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Previous work identified the Rap1 GTPase-activating protein Sipa1 as a germ-line-encoded metastasis modifier.
|
18427120 |
2008 |
|
leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Several candidate genes which were differentially expressed in MDS patients versus normal controls were selected and confirmed in expanding samples by quantitative real-time reverse transcription-polymerase chain reaction after clustering and bioinformatics analysis. one of these genes, RAP1GAP, was found to be expressed at a significantly higher level in patients with MDS in comparison with those suffering from other hematopoietic diseases including leukemia (P < 0.01).
|
18551404 |
2008 |
|
Childhood Leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Several candidate genes which were differentially expressed in MDS patients versus normal controls were selected and confirmed in expanding samples by quantitative real-time reverse transcription-polymerase chain reaction after clustering and bioinformatics analysis. one of these genes, RAP1GAP, was found to be expressed at a significantly higher level in patients with MDS in comparison with those suffering from other hematopoietic diseases including leukemia (P < 0.01).
|
18551404 |
2008 |
|
MYELODYSPLASTIC SYNDROME
|
0.020 |
AlteredExpression
|
group |
BEFREE |
We propose that over-expression of RAP1GAP gene may play a role in the pathogenesis of MDS.
|
18551404 |
2008 |
|
MYELODYSPLASTIC SYNDROME
|
0.020 |
AlteredExpression
|
group |
LHGDN |
We propose that over-expression of RAP1GAP gene may play a role in the pathogenesis of MDS.
|
18551404 |
2008 |
|
Thyroid Neoplasm
|
0.350 |
Biomarker
|
disease |
BEFREE |
The more frequent and greater down-regulation of Rap1GAP in PTCs compared with adenomas suggests a role for Rap1GAP depletion in the progression of human thyroid tumors, possibly through unrestrained Rap activity.
|
19066305 |
2009 |
|
melanoma
|
0.340 |
Biomarker
|
disease |
CTD_human |
Taken together, our findings indicate that down-regulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival, and migration.
|
19147557 |
2009 |
|
melanoma
|
0.340 |
AlteredExpression
|
disease |
LHGDN |
Taken together, our findings indicate that down-regulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival, and migration.
|
19147557 |
2009 |
|
melanoma
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
In addition, overexpression of Rap1GAP also inhibits focal adhesion formation and decreases melanoma cell migration.
|
19147557 |
2009 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Rap1GAP down-regulation is due to its promoter methylation, a mechanism of gene silencing in tumors.
|
19147557 |
2009 |