|
Thyroid Neoplasm
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
These findings identify SRC as a target of RAP1GAP depletion and suggest that the downregulation of RAP1GAP in thyroid tumors enhances SRC-dependent signals that regulate cellular architecture and motility.
|
22696507 |
2012 |
|
melanoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
Genes deregulated at the DNA and mRNA level included well-known cancer genes partly already linked to melanoma (RAS genes, PTEN, AURKA, MAPK inhibitors Sprouty/Spred), but also novel candidates like SIPA1 (a Rap1GAP).
|
22535842 |
2012 |
|
melanoma
|
0.340 |
Biomarker
|
disease |
CTD_human |
Rap1GAP is thought of as a putative tumor suppressor gene and plays an important role in human tumor progression including pancreatic cancer, thyroid cancer and melanoma.
|
22614916 |
2012 |
|
melanoma
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, miR-31 overexpression resulted in down-regulation of EZH2 and a de-repression of its target gene rap1GAP; increased expression of EZH2 was associated with melanoma progression and overall patient survival.
|
22948084 |
2012 |
|
melanoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
Rap1GAP is thought of as a putative tumor suppressor gene and plays an important role in human tumor progression including pancreatic cancer, thyroid cancer and melanoma.
|
22614916 |
2012 |
|
Thyroid carcinoma
|
0.340 |
Biomarker
|
disease |
CTD_human |
Rap1GAP is thought of as a putative tumor suppressor gene and plays an important role in human tumor progression including pancreatic cancer, thyroid cancer and melanoma.
|
22614916 |
2012 |
|
Thyroid carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
Rap1GAP is thought of as a putative tumor suppressor gene and plays an important role in human tumor progression including pancreatic cancer, thyroid cancer and melanoma.
|
22614916 |
2012 |
|
Thyroid carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
RAP1GAP inhibits cytoskeletal remodeling and motility in thyroid cancer cells.
|
22696507 |
2012 |
|
Malignant neoplasm of pancreas
|
0.330 |
Biomarker
|
disease |
BEFREE |
Rap1GAP is thought of as a putative tumor suppressor gene and plays an important role in human tumor progression including pancreatic cancer, thyroid cancer and melanoma.
|
22614916 |
2012 |
|
Malignant neoplasm of pancreas
|
0.330 |
Biomarker
|
disease |
CTD_human |
Rap1GAP is thought of as a putative tumor suppressor gene and plays an important role in human tumor progression including pancreatic cancer, thyroid cancer and melanoma.
|
22614916 |
2012 |
|
Pancreatic Neoplasm
|
0.310 |
Biomarker
|
disease |
CTD_human |
Rap1GAP alters leukemia cell differentiation, apoptosis and invasion in vitro.
|
22614916 |
2012 |
|
Acute Promyelocytic Leukemia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Rap1GAP alters leukemia cell differentiation, apoptosis and invasion in vitro.
|
22614916 |
2012 |
|
Thyroid Gland Follicular Adenoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Rap1GAP alters leukemia cell differentiation, apoptosis and invasion in vitro.
|
22614916 |
2012 |
|
Disease Exacerbation
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Rap1GAP alters leukemia cell differentiation, apoptosis and invasion in vitro.
|
22614916 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Rap1GAP is thought of as a putative tumor suppressor gene and plays an important role in human tumor progression including pancreatic cancer, thyroid cancer and melanoma.
|
22614916 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The functional significance of decreased RAP1GAP protein expression in human tumors is unclear.
|
22696507 |
2012 |
|
Tumor Cell Invasion
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
RCC cell lines express distinct levels of cell adhesion proteins and the forced over-expression of Rap1GAP attenuated levels of both cadherins and integrins that are known to regulate the cancer cells invasion.
|
22266190 |
2012 |
|
Tumor Cell Invasion
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
In addition, we found that increased expression of Rap1GAP promoted leukemia cell invasion may be due to matrix metalloproteinase 9 (MMP9).
|
22614916 |
2012 |
|
Tumor Progression
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Rap1GAP is thought of as a putative tumor suppressor gene and plays an important role in human tumor progression including pancreatic cancer, thyroid cancer and melanoma.
|
22614916 |
2012 |
|
Malignant neoplasm of thyroid
|
0.030 |
Biomarker
|
disease |
BEFREE |
RAP1GAP inhibits cytoskeletal remodeling and motility in thyroid cancer cells.
|
22696507 |
2012 |
|
Malignant neoplasm of thyroid
|
0.030 |
Biomarker
|
disease |
BEFREE |
Rap1GAP is thought of as a putative tumor suppressor gene and plays an important role in human tumor progression including pancreatic cancer, thyroid cancer and melanoma.
|
22614916 |
2012 |
|
Neoplasm Metastasis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
These results demonstrate that targeted restoration of Rap1GAP expression may serve as a potential therapeutic approach to reduce metastasis of kidney cancers.
|
22266190 |
2012 |
|
Pancreatic carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Rap1GAP is thought of as a putative tumor suppressor gene and plays an important role in human tumor progression including pancreatic cancer, thyroid cancer and melanoma.
|
22614916 |
2012 |
|
leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
In conclusion, these results demonstrated that Rap1GAP promoted leukemia cell differentiation and apoptosis, but increased leukemia cell invasion in vitro.
|
22614916 |
2012 |
|
Leukemia, Myelocytic, Acute
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In the current study, we found that the expression of Rap1GAP was lower in acute myeloid leukemia (AML) patients compared to non-malignant blood disease patients.
|
22614916 |
2012 |