|
Retinoblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
We previously isolated and identified retinoblastoma-associated proteins 46 (RbAp46) and 48 (RbAp48), which are associated with chromatin remodeling, histone deacetylation, and transcription repression, as proteins associated with the DNA-bound ERalpha.
|
18577416 |
2008 |
|
Retinoblastoma
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Retinoblastoma‑associated protein 48 (RbAp48), a highly abundant component of HDACs, is a critical mediator that controls the transforming activity of human papillomavirus 16 in cervical cancer cells.
|
28138695 |
2017 |
|
Retinoblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Retinoblastoma binding protein 4 (RbAp48) is a histone chaperone which has been suggested to play a role in gene silencing.
|
27222146 |
2016 |
|
Retinoblastoma
|
0.050 |
Biomarker
|
disease |
LHGDN |
This RbAp48-mediated transformation of HPV16 is probably because of the regulation by RbAp48 of tumor suppressors retinoblastoma and p53, apoptosis-related enzymes caspase-3 and caspase-8, and oncogenic genes, including E6, E7, cyclin D1 (CCND1), and c-MYC.
|
17616526 |
2007 |
|
Retinoblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
PLK1, SOD1, E2F-3, two retinoblastoma binding proteins (RBQ1 and RBBP4) and HDGF were reduced after Bmi-1 inhibition.
|
17454639 |
2007 |
|
Retinoblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
This RbAp48-mediated transformation of HPV16 is probably because of the regulation by RbAp48 of tumor suppressors retinoblastoma and p53, apoptosis-related enzymes caspase-3 and caspase-8, and oncogenic genes, including E6, E7, cyclin D1 (CCND1), and c-MYC.
|
17616526 |
2007 |
|
Amnesia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Rbbp4 (involved in age-related memory loss) was increased in tibia callus after ovariectomy.
|
28860177 |
2018 |
|
Amnesia
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Up-regulation of RbAp48 in the DG of aged wild-type mice ameliorated age-related hippocampus-based memory loss and age-related abnormalities in histone acetylation.
|
23986399 |
2013 |
|
Amnesia
|
0.040 |
Biomarker
|
disease |
BEFREE |
We have previously shown that the histone-binding protein RbAp48/Rbbp4 is a molecular determinant of Age-Related Memory Loss.
|
30355501 |
2018 |
|
Amnesia
|
0.040 |
Biomarker
|
disease |
BEFREE |
The epigenetic factor LIN-53 (RBBP4/7) associates with different chromatin-regulating complexes to safeguard cell identities in Caenorhabditis elegans as well as mammals, and has a role in preventing memory loss and premature aging in humans.
|
31397537 |
2019 |
|
Malignant tumor of cervix
|
0.030 |
Biomarker
|
disease |
BEFREE |
RbAp48 may be a potential target to improve the results of radiation therapy for patients with cervical cancer.
|
23756179 |
2013 |
|
Malignant tumor of cervix
|
0.030 |
Biomarker
|
disease |
BEFREE |
RbAp48 may be a therapeutic target that may help to improve the treatment of cervical cancer.
|
28138695 |
2017 |
|
Malignant tumor of cervix
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In brief, RbAp48, previously unknown in cervical carcinogenesis, was isolated in a global screen and identified as a critical mediator controlling the transforming activity of HPV16 in cervical cancer.
|
17616526 |
2007 |
|
Cervix carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
RbAp48 may be a potential target to improve the results of radiation therapy for patients with cervical cancer.
|
23756179 |
2013 |
|
Cervix carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In brief, RbAp48, previously unknown in cervical carcinogenesis, was isolated in a global screen and identified as a critical mediator controlling the transforming activity of HPV16 in cervical cancer.
|
17616526 |
2007 |
|
Cervix carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
RbAp48 may be a therapeutic target that may help to improve the treatment of cervical cancer.
|
28138695 |
2017 |
|
Oestrogen deficiency
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Recently, we found that retinoblastoma-associated protein 48 (RbAp48) induces tissue-specific apoptosis in the exocrine glands depending on the level of estrogen deficiency.
|
19015307 |
2008 |
|
Oestrogen deficiency
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
These findings demonstrated that estrogen deficiency initiates tissue-specific apoptosis in the exocrine gland cells through RbAp48 overexpression and exerts a possible gender-based risk of autoimmune exocrinopathy in postmenopausal women.
|
20635899 |
2010 |
|
Oestrogen deficiency
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Zileuton caused downregulation of Rbbp4 in the hippocampus and had an effect on bone healing, changed the expression of genes involved in cross talk between bones and brain, and may be a potent drug for further examination in estrogen deficiency-related dysfunction(s).
|
28860177 |
2018 |
|
cervical cancer
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In brief, RbAp48, previously unknown in cervical carcinogenesis, was isolated in a global screen and identified as a critical mediator controlling the transforming activity of HPV16 in cervical cancer.
|
17616526 |
2007 |
|
cervical cancer
|
0.030 |
Biomarker
|
disease |
BEFREE |
RbAp48 may be a potential target to improve the results of radiation therapy for patients with cervical cancer.
|
23756179 |
2013 |
|
cervical cancer
|
0.030 |
Biomarker
|
disease |
BEFREE |
RbAp48 may be a therapeutic target that may help to improve the treatment of cervical cancer.
|
28138695 |
2017 |
|
Sjogren's Syndrome
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In this study, we report that transgenic (Tg) expression of RbAp48 resulted in the development of autoimmune exocrinopathy resembling Sjögren's syndrome.
|
19015307 |
2008 |
|
Sjogren's Syndrome
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Indeed, transgenic expression of the RbAp48 gene induced apoptosis in the exocrine glands, resulting in the development of autoimmune exocrinopathy resembling Sjögren's syndrome (SS).
|
20635899 |
2010 |
|
Sjogren's Syndrome
|
0.020 |
AlteredExpression
|
disease |
LHGDN |
Expression of the retinoblastoma protein RbAp48 in exocrine glands leads to Sjögren's syndrome-like autoimmune exocrinopathy.
|
19015307 |
2008 |