|
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, the rate of CCND1 amplification differed between different subsites in SCCHN and was also associated to a more aggressive tumour phenotype, as defined by DNA non-diploidy and high SPF.
|
15063391 |
2004 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
On transduction of the human HNSCC cell line with adenovirus-p27 (Ad-p27), a high level of p27 expression and increase of cyclin D1 and E were observed.
|
12478543 |
2003 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Differential alterations of the genes in the CDKN2A-CCND1-CDK4-RB1 pathway are associated with the development of head and neck squamous cell carcinoma in Indian patients.
|
14586645 |
2003 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
The gene ratios c-MYC:cyclin-dependent kinase (CDK)N2A and CCND1:CDKN2A correlate with poor prognosis in squamous cell carcinoma of the head and neck.
|
12738730 |
2003 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In the present study, 32 squamous cell carcinoma of the head and neck (SCCHN) were investigated regarding chromosomal abnormalities involving 11q13 by cytogenetic analysis, genomic CCND1 amplification by differential PCR and FISH, and cyclin D1 expression on the mRNA and protein level by differential RT-PCR and immunohistochemistry, respectively.
|
11743641 |
2002 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cyclin D1, a cell cycle regulator localized to chromosome 11q13, is amplified in several human tumors including head and neck squamous cell carcinoma (HNSCC).
|
12148857 |
2002 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma.
|
12067972 |
2002 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We found that SCCHN cells stably transfected with a dominant active STAT3 construct expressed elevated levels of STAT3 target genes, including Bcl-X(L) and cyclin D1, and demonstrated increased proliferation in vitro and more rapid tumor growth rates in vivo.
|
12193474 |
2002 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This study indicates that immunohistochemical assessment of cyclin D1 expression in SCCHN could be a new predictive marker to select a subgroup of patients that will benefit from neoadjuvant chemotherapy.
|
11504311 |
2001 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We have now examined the association of this and a second CCND1 polymorphism with gene expression and outcome in SCCHN patients.
|
11696452 |
2001 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
Abrogation of cyclin D1 action through antisense cyclin D1 shows promise as an antitumor therapy, with an inhibitory effect in head and neck squamous cell carcinoma both in vitro and in vivo.
|
11404608 |
2001 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Amplification of the cyclin D1 gene has been identified in 17-55% of head and neck squamous cell carcinoma.
|
11287281 |
2001 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Compared with the wild-type CCND1 GG, the CCND1 A G genotype was associated with a non-significantly increased risk (adjusted OR 1.15, 95% CI 0.75-1.76), but the CCND1 AA genotype was associated with a significantly increased risk (adjusted OR 1.77, 95% CI 1.04-3.02) for SCCHN.
|
11470749 |
2001 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data indicate that EMS1 amplification, but not CCND1 amplification, predicts early recurrence and reduced survival in squamous cell carcinoma of the head and neck.
|
10955801 |
2000 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
Over-expression of oncogenes, genes mainly involved in cell signalling, especially those on chromosome 11 (PRAD-1 in particular) and 17 (H-ras) and mutations in DNA repair genes, have also been implicated in the carcinogenesis of SCCHN.
|
10899669 |
2000 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Cyclin D1 amplification is independent of p16 inactivation in head and neck squamous cell carcinoma.
|
10376532 |
1999 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of cyclin D1, a G1 cell cycle regulator, is often found in many different tumor types, such as breast carcinoma and squamous cell carcinoma of the head and neck.
|
10070974 |
1999 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism within the cyclin D1 gene is associated with prognosis in patients with squamous cell carcinoma of the head and neck.
|
9796972 |
1998 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
The combined analysis of the p53 and cyclin D1 abnormalities seems to be more informative than either of them individually and may have predictive value in SCCHN.
|
9504605 |
1998 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings suggest that cyclin D1 plays an important role in tumorigenesis of HNSCC, and gene amplification is not one of the major mechanisms for overexpression of cyclin D1.
|
9310139 |
1997 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In Series 1, overexpression of cyclin D1 and 11q13 rearrangements, assessed by immunohistochemistry and cytogenetics, respectively, were compared with clinical data in 75 patients with SCCHN.
|
9010112 |
1997 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
These suggest that CCND1 amplification occurs at early stages of HNSCC tumorigenesis and is a more useful prognostic factor than over-expression of cyclin D1 in HNSCC.
|
9421351 |
1997 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
Southern blotting was used to identify CCND1 amplification in 57 previously untreated HNSCC tumor specimens Tissue from 27 cases was analyzed for CCND1 mRNA expression by Northern biot analysis.
|
8902564 |
1997 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Cyclin D1 (PRAD1, CCND1) and glutathione-S-transferase pi gene expression in head and neck squamous cell carcinoma.
|
7590696 |
1995 |
|
Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of cyclin D1 appears to indicate poor prognosis in operable HNSCC.
|
7867006 |
1995 |