|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
We also revealed in the Ohasama Study that the Trp460 allele of ADD1 is associated with hypertension in young subjects with low renin activity.
|
12924618 |
2003 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
This mechanism is related either to a mutation of the gene, which encodes 11HSD2 (apparent mineralocorticoid excess syndrome and some cases of low renin hypertension) or to an acquired reduction of the activity of the enzyme due to glycyrrhetinic acid, carbenoxolone, and grapefruit juice.
|
12892318 |
2003 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Furthermore, an association of any renin allele with hypertension was not apparent.
|
3319438 |
1987 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
New questions for the next 5 years include a single accepted confirmatory/exclusion test; standardisation of assays and cut-offs; alternatives to universal adrenal venous sampling; reclassification of 'low renin hypertension'; recognition of the extent of 'occult' PA; inclusion of low-dose mineralocorticoid receptor antagonist in first-line therapy for hypertension; and finally, possible resolution of the aldosterone/inappropriate sodium status enigma at the heart of the cardiovascular damage in PA.
|
26588848 |
2015 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Body sodium, the cardiovascular pressor reactivity to infused noradrenaline or angiotensin II, plasma levels of noradrenaline, adrenalin, renin, angiotensin II, aldosterone and atrial natriuretic peptide were measured on a low or high sodium diet in 10 normotensive young subjects without and 13 normotensive subjects with familial predisposition to hypertension.
|
3065505 |
1988 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The presence of an MboI site in an RFLP in the renin gene and the Thr at the Met/Thr polymorphism at codon 235 (M235T) of the angiotensinogen gene have been reported to be associated with hypertension.
|
11803527 |
2001 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
We examined the distribution of common alleles of the ACE gene and measured circulating components of the renin-angiotensin system and urinary sodium excretion in 170 young Caucasian adults with contrasting genetic predisposition to high blood pressure.
|
8384602 |
1993 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Other potential factors that could cause hypertension in programmed rats, such as the renin-angiotensin system, are also discussed.
|
27001053 |
2018 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The present study suggests that the -344C/T polymorphism, or a functional variant in linkage disequilibrium with it, may play a role in the abnormal regulation of aldosterone secretion in idiopathic low renin hypertension.
|
11587161 |
2001 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
We have studied an unusual patient with mild low-renin hypertension due to a homozygous mutation in the HSD11B2 gene (PNAS 95:10200-10205, 1998).
|
10599743 |
1999 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Obesity may compound the increased risk of hypertension and cardiovascular disease in individuals born prematurely by further augmenting the prematurity-associated imbalance in the renin-angiotensin system.
|
30404738 |
2019 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Because hypertension in Black people tends to be of the low-renin, salt sensitive type, we genotyped independent sets of hypertensives of Afro-American (59 kindreds) and Afro-Caribbean (66 kindreds) origin using a highly polymorphic (heterozygosity index 0.84) CA repeat polymorphism in the first intron of HSD11B2.
|
11531933 |
2001 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
This systematic review investigates the high level of hypertension found among urban dwellers in West Africa and in the West African Diaspora in the Americas in relation to variants within the genes encoding the renin angiotensinogen system.
|
26607294 |
2016 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Variation at the aldosterone synthase (CYP11B2) locus contributes to hypertension in subjects with a raised aldosterone-to-renin ratio.
|
12213905 |
2002 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
We have tested this hypothesis using genes encoding components of the renin-angiotensin-aldosterone system and the high blood pressure phenotype.
|
20525211 |
2010 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms in the renin-angiotensin system, such as the recently described insertion/deletion polymorphism in the angiotensin I converting enzyme (ACE) gene, may predispose to hypertension and related disorders because of an advantage they confer in thermoregulation.
|
8822230 |
1996 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Both of these forms of inherited hypertension are low-renin forms of hypertension.
|
8903606 |
1995 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Gene variants of the renin-angiotensin system and hypertension: from a trough of disillusionment to a welcome phase of enlightenment?
|
20088829 |
2010 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
R563Q, a new variant of the beta epithelial sodium channel, is associated with low-renin, low-aldosterone hypertension, in South African black and mixed-ancestry patients.
|
12714866 |
2003 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Two novel hypertension susceptibility genes are presented, and a short summary on new insights into genes of the renin-angiotensin and adrenergic systems is given.
|
17413273 |
2007 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Since the renin gene is a member of a conserved synteny group that in humans spans chromosome 1q21.3-32.3 and includes the gene for antithrombin III (AT3), we used linkage studies to examine the relationship between alleles of AT3 and hypertension in a family having 10 affected members.2.
|
1676620 |
1991 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
This review discusses a number of such techniques and their applicability to the study of diabetes and hypertension with the renin-angiotensin system as an example.
|
1281007 |
1992 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Gene polymorphisms of the renin-angiotensin system are involved in the pathophysiology of hypertension.
|
23716723 |
2014 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Several signalling pathways have been studied and related to the development and progression of RH: modulation of sympathetic activity by leptin and aldosterone, primary aldosteronism, arterial stiffness, endothelial dysfunction and variations in the renin-angiotensin-aldosterone system (RAAS). miRNAs comprise a family of small non-coding RNAs that participate in the regulation of gene expression at post-transcriptional level. miRNAs are involved in the development of both cardiovascular damage and hypertension.
|
29184046 |
2017 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Our results showed the association of renin-angiotensin-aldosterone system gene haplotypes with hypertension.
|
17183494 |
2006 |