RET, ret proto-oncogene, 5979

N. diseases: 607; N. variants: 162
Disease: Thyroid Neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Germline RET mutations in exons 10 and 11: an Iranian survey of 57 medullary thyroid carcinoma cases. 17623957 2006
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Fine-needle aspiration molecular analysis for the diagnosis of papillary thyroid carcinoma through BRAF V600E mutation and RET/PTC rearrangement. 17727338 2007
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. 12670889 2003
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 AlteredExpression disease LHGDN High prevalence of c-RET expression in papillary thyroid carcinomas from the Korean population. 15785245 2005
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 Biomarker disease LHGDN Penetrance and clinical manifestations of non-hotspot germline RET mutation, C630R, in a family with medullary thyroid carcinoma. 16053382 2005
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 AlteredExpression disease LHGDN High prevalence of RET, RAS, and ERK expression in Hashimoto's thyroiditis and in papillary thyroid carcinoma in the Korean population. 17900235 2007
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN RET exon 11 (G691S) polymorphism is significantly more frequent in sporadic medullary thyroid carcinoma than in the general population. 15240649 2004
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN An in-frame complex germline mutation in the juxtamembrane intracellular domain causing RET activation in familial medullary thyroid carcinoma. 16954442 2006
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Does a somatic deletion in RET clarify the sporadic nature of medullary thyroid carcinoma? 12841548 2003
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 Biomarker disease LHGDN Synergistic effect of oncogenic RET and loss of p18 on medullary thyroid carcinoma development. 18316595 2008
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN [Proto-oncogene RET somatic mutations in medullary thyroid carcinoma]. 12182058 2001
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN A founding locus within the RET proto-oncogene may account for a large proportion of apparently sporadic Hirschsprung disease and a subset of cases of sporadic medullary thyroid carcinoma. 12474140 2003
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN A break-apart fluorescence in situ hybridization assay for detecting RET translocations in papillary thyroid carcinoma. 17954268 2007
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Concurrent lymph node metastases of medullary and papillary thyroid carcinoma in a case with RET oncogene germline mutation. 14586073 2003
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN The occurrence and the type of germline mutations in the RET gene in patients with medullary thyroid carcinoma and their unaffected kindred's from Central Poland. 18058472 2007
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 Biomarker disease LHGDN Molecular mechanisms of medullary thyroid carcinoma: current approaches in diagnosis and treatment. 17952863 2008
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 Biomarker disease LHGDN Role of MEN2A-derived RET in maintenance and proliferation of medullary thyroid carcinoma. 15316058 2004
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Clinical case seminar: in vivo and in vitro characterization of a novel germline RET mutation associated with low-penetrant nonaggressive familial medullary thyroid carcinoma. 16384843 2006
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN The finding of a somaticdeletion in RET exon 15 clarified the sporadic nature of amedullary thyroid carcinoma suspected to be familial. 11883863 2002
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN High resolution array-comparative genomic hybridization profiling reveals deoxyribonucleic acid copy number alterations associated with medullary thyroid carcinoma. 18765511 2008
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN RET polymorphisms and sporadic medullary thyroid carcinoma in a Portuguese population. 16230779 2005
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Novel germline RET mutation segregating with papillary thyroid carcinomas. 11746981 2001
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN RET genetic screening in patients with medullary thyroid cancer and their relatives: experience with 807 individuals at one center. 17895320 2007
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Investigation of loss of heterozygosity and SNP frequencies in the RET gene in papillary thyroid carcinoma. 15753666 2005
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Molecular classification of papillary thyroid carcinoma: distinct BRAF, RAS, and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysis. 16007166 2005