|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
Detection of dual translocations predominantly in low-grade FLs suggests that BCL6 abnormalities are acquired early in the histologic evolution of a subset of IgH/BCL2-associated FLs.
|
18628087 |
2008 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, analysis by Fluorescence in situ hybridization of BCL6 gene aberrations in 100 follicular lymphoma cases without IGH/BCL2 rearrangement resulted in the identification of four subgroups.
|
18500267 |
2008 |
|
Lymphoma, Follicular
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
The analysis suggests that MUM1 expression dichotomises FL into low-grade FL of CD10+/Bcl-6+/MUM1-/Ki-67low phenotype, and high-grade FL of CD10+/- /Bcl-6+/weak/MUM1+/ Ki-67high phenotype.
|
17296585 |
2007 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, CD10-MUM1+ FLs were encountered frequently in the elderly compared with CD10+MUM1- typical FLs (67.0 versus 58.7 years, P < .01), showed high grade (grade 3A or 3B) morphology (91% versus 17%, P < .001), diffuse proliferation (59% vs 19%, P < .001), and lacked BCL2/IGH translocation (5% versus 92.5%, P < .001), which is the most characteristic aberration in FL, and 88% showed BCL6 gene abnormalities (translocation or amplification).
|
17138820 |
2007 |
|
Lymphoma, Follicular
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We investigated the expression of MUM1 (multiple myeloma oncogene 1)/IRF4 (interferon regulatory factor 4) in 46 cases of follicular lymphoma (FL) and correlated this with grade and expression of CD10, Bcl-6 and Ki-67.
|
17296585 |
2007 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Rearrangement of the BCL6 gene is found in follicular lymphomas and in diffuse large B cell lymphomas of follicular center cell origin.
|
17175383 |
2007 |
|
Lymphoma, Follicular
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In some cases of Bcl2-negative FL there was high expression of Bcl6 or p53 but no such Bcl2-positive FL cases were detected.
|
17295647 |
2007 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that the der(3)t(3;18)(q27;q21) involving BCL2 and BCL6 had a crucial role in the pathogenesis of FL with t(3;14;18)(q27;q32;q21).
|
17981218 |
2007 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
Chromosomal translocations (CTs) between immunoglobulin (Ig) genes and the BCL6 proto-oncogene are frequently associated with diffuse large B-cell lymphomas (DLBCLs) and follicular lymphomas (FLs) and are implicated in the development of these lymphomas.
|
16728698 |
2006 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mutations in the 5'-regulatory region of BCL6 were suggested to play a role in non-Hodgkin's lymphoma (NHL) progression and in the transformation of follicular lymphoma to more aggressive diffuse large B-cell type.
|
16125304 |
2006 |
|
Lymphoma, Follicular
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
BCL6, a transcriptional repressor frequently translocated in lymphomas, including diffuse large B-cell lymphoma (DLBCL) and transformed follicular lymphoma (FL), regulates germinal center B-cell differentiation.
|
17088997 |
2006 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we further characterized the FL3B lymphomas that are currently part of the spectrum of FL in the WHO classification, taking into account other cytogenetical aberrations, immunohistochemistry for P53, bcl2, bcl6, and CD10, rearrangement of the proto-oncogene myc, and mutation of the tumor suppressor gene TP53.
|
16647949 |
2006 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Translocations involving 3q27 that affect the BCL6 gene are common and specific chromosomal abnormalities in B-cell precursor non-Hodgkin lymphoma (mainly diffuse large-cell and follicular lymphoma), but they have not been reported in Burkitt lymphoma.
|
16772123 |
2006 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Translocation of BCL2 and BCL6 to the same immunoglobulin heavy chain locus in a case of follicular lymphoma.
|
16194898 |
2005 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
We present here a case of Follicular Lymphoma with leukemic presentation and a complex translocation involving the IgH, BCL2 and BCL6 loci.
|
16194898 |
2005 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently, it has also been reported that FL lacks t(14;18), mainly among histological grade 3b, and occasionally has a rearranged Bcl-6 gene.
|
15723651 |
2005 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recent data suggest an alternative breakpoint cluster region (ABR) located between 245 and 285 kb 5' of BCL6, which might be associated with Follicular Lymphoma (FL).
|
16075463 |
2005 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Based on a case-control study, BCL6 SNPs frequencies were assessed in 97 t(14;18) follicular lymphomas (FL) and in 54 lymphomas with 3q27 rearrangement.
|
16094416 |
2005 |
|
Lymphoma, Follicular
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
BCL6 is a transcriptional repressor required for germinal center formation, and the gene encoding it is frequently altered in diffuse large B-cell and follicular lymphomas.
|
16147992 |
2005 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, the incidence of bcl-6 hypermutation in FL and DLCL cases appeared to be comparable.
|
15875184 |
2005 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
Bcl2, Bcl6 and CD10 are phenotypic markers of FL while the Bcl2 t(14;18) and Bcl6 t(3q27) gene translocations are common genetic changes.
|
15815725 |
2005 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The accumulation of mutations in BCL6 during high grade transformation of FL, a mutational clustering and specific recurrent mutations suggest that some mutations may be selected for by their effect on the survival of the tumoral clone.
|
16019457 |
2005 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Based on a case-control study, BCL6 SNPs frequencies were assessed in 97 t(14;18) follicular lymphomas (FL) and in 54 lymphomas with 3q27 rearrangement.
|
16094416 |
2005 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
To clarify the prevalence of BCL6 and BCL2 rearrangements in FL and diffuse large B-cell lymphomas (DLBLs), we performed a large scale bicolor interphase cytogenetic (fluorescence in situ hybridization) study on 188 well-characterized B-NHLs classified according to the World Health Organization Classification of Tumors of the Lymphoid Tissues.
|
15277222 |
2004 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Only two primary FLs and two diffuse large BCL showed bcl6 somatic mutation.
|
15098010 |
2004 |