|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The Impact of BDNF Polymorphisms on Suicidality in Treatment-Resistant Major Depressive Disorder: A European Multicenter Study.
|
28977521 |
2017 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We genotyped the BDNF-gene Val66Met polymorphism in 110 elderly inpatients diagnosed with major depression and 171 age- and sex-similar control subjects.
|
16343697 |
2006 |
|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
The decrease of brain-derived neurotrophic factor (BDNF) has been reported in alcohol use disorder and major depression.
|
28837087 |
2017 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
BDNF and NRG1 polymorphisms and temperament in selective serotonin reuptake inhibitor-treated patients with major depression.
|
29310728 |
2018 |
|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Such an association would be consistent with low brain-derived neurotrophic factor mediating the effect of early life adversity on adulthood suicide and major depressive disorder.
|
29432620 |
2018 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity.
|
18852698 |
2010 |
|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Association of 2 neurotrophic factor polymorphisms with efficacy of paroxetine in patients with major depressive disorder in a Chinese population.
|
24577123 |
2014 |
|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Evidence for an association between brain-derived neurotrophic factor Val66Met gene polymorphism and general intellectual ability in early-onset schizophrenia.
|
22801293 |
2012 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We did not find an association between the melancholic subtype of major depression and the BDNF genotype and SLE interaction in this sample, which is representative of the Hungarian clinic-referred population of depressed youths.
|
26462036 |
2015 |
|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
BDNF Val66Met genotype interacts with childhood adversity and influences the formation of hippocampal subfields.
|
25044977 |
2014 |
|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
This review provides a critical review of the involvement of BDNF in major depression, in general, and in late-life depression, in particular.
|
23570887 |
2013 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association of brain-derived neurotrophic factor valine to methionine polymorphism with sexual dysfunction following selective serotonin reuptake inhibitor treatment in female patients with major depressive disorder.
|
27787964 |
2016 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No association of the Val66Met polymorphism of the brain-derived neurotrophic factor with hippocampal volume in major depression.
|
19668114 |
2009 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Hippocampal volumes and the brain-derived neurotrophic factor val66met polymorphism in geriatric major depression.
|
21218562 |
2011 |
|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Molecular evidence for BDNF- and GABA-related dysfunctions in the amygdala of female subjects with major depression.
|
21912391 |
2012 |
|
Unipolar Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression.
|
18752720 |
2008 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The effects of 5-HTTLPR and BDNF Val66Met polymorphisms on neurostructural changes in major depressive disorder.
|
29414128 |
2018 |
|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our findings provide further evidence for an interaction of the HPA axis and the neurotrophin system in major depression.
|
31295515 |
2019 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated the relationship between a brain-derived neurotrophic factor (BDNF) polymorphism (Val66Met) and the clinical response of patients with major depressive disorder to selective serotonin reuptake inhibitors (SSRIs; here, paroxetine and sertraline).
|
21338649 |
2011 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Of the 21 SNPs, TAL1 rs2984618 obesity-risk allele was associated with a higher risk of major depressive disorder (P = 1.79 × 10(-4), adjusted for age, sex, BMI, and ethnicity), and BDNF rs1401635 demonstrated significant ethnic-dependent association with major depressive disorder (OR = 0.88; 95% CI, 0.80-0.97; P = .01 in non-Europeans and OR = 1.11; 95% CI, 1.02-1.20; P = .02 in Europeans; Pinteraction = 2.73 × 10(-4)).
|
26717541 |
2015 |
|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
There is a plausible role for cytokines, brain-derived neurotrophic factor (BDNF), and their interaction in major depressive disorder's (MDD) etiology.
|
22681170 |
2012 |
|
Unipolar Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Brains from persons with major depressive disorder reveal decreased expression for genes in glutamate transport and metabolism, neurotrophic signaling (eg, FGF, BDNF and VGF), and MAP kinase pathways.
|
18923405 |
2009 |
|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
CTD_human |
Increased expression of the Vesicular Glutamate Transporter-1 (VGLUT1) in the prefrontal cortex correlates with differential vulnerability to chronic stress in various mouse strains: effects of fluoxetine and MK-801.
|
21945287 |
2012 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No effect of 5HTTLPR or BDNF Val66Met polymorphism on hippocampal morphology in major depression.
|
21692988 |
2011 |
|
Unipolar Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Compared with individuals without a BDNF met allele, met-allele carriers have a lower expression of BDNF, which has been associated with Major Depressive Disorder.
|
20230085 |
2010 |