BDNF, brain derived neurotrophic factor, 627

N. diseases: 992; N. variants: 56
Disease: Unipolar Depression ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0041696
Disease:
Unipolar Depression 		0.100 GeneticVariation BEFREE We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression. 31721892 2019
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0041696
Disease:
Unipolar Depression 		0.100 GeneticVariation BEFREE Association of BDNF Val66Met Polymorphism and Brain BDNF Levels with Major Depression and Suicide. 29432620 2018
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0041696
Disease:
Unipolar Depression 		0.100 GeneticVariation BEFREE The effects of 5-HTTLPR and BDNF Val66Met polymorphisms on neurostructural changes in major depressive disorder. 29414128 2018
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0041696
Disease:
Unipolar Depression 		0.100 GeneticVariation BEFREE Val66Met polymorphism association with serum BDNF and inflammatory biomarkers in major depression. 28656803 2018
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0041696
Disease:
Unipolar Depression 		0.100 GeneticVariation BEFREE Val66Met polymorphism association with serum BDNF and inflammatory biomarkers in major depression. 28656803 2018
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0041696
Disease:
Unipolar Depression 		0.100 GeneticVariation BEFREE The effects of 5-HTTLPR and BDNF Val66Met polymorphisms on neurostructural changes in major depressive disorder. 29414128 2018
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0041696
Disease:
Unipolar Depression 		0.100 GeneticVariation BEFREE Association of BDNF Val66Met Polymorphism and Brain BDNF Levels with Major Depression and Suicide. 29432620 2018
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0041696
Disease:
Unipolar Depression 		0.100 GeneticVariation BEFREE Plasma BDNF Level in Major Depression: Biomarker of the Val66Met BDNF Polymorphism and of the Clinical Course in Met Carrier Patients. 28848102 2017
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0041696
Disease:
Unipolar Depression 		0.100 GeneticVariation BEFREE Plasma BDNF Level in Major Depression: Biomarker of the Val66Met BDNF Polymorphism and of the Clinical Course in Met Carrier Patients. 28848102 2017
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0041696
Disease:
Unipolar Depression 		0.100 GeneticVariation BEFREE Effects of polymorphisms of serotonin transporter promoter (5-HTTLPR) and brain derived neurotrophic factor gene (G196A rs6265) on the risk of major depressive disorder in the Chinese Han population. 27212180 2016
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0041696
Disease:
Unipolar Depression 		0.100 GeneticVariation BEFREE Effects of polymorphisms of serotonin transporter promoter (5-HTTLPR) and brain derived neurotrophic factor gene (G196A rs6265) on the risk of major depressive disorder in the Chinese Han population. 27212180 2016
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0041696
Disease:
Unipolar Depression 		0.100 GeneticVariation BEFREE Our study aimed to clarify whether, in the presence of previous childhood maltreatment, individuals carrying low functional alleles for both SERT 5-HTTLPR and BDNF Val66Met polymorphisms had a higher risk for MD. 25510949 2015
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0041696
Disease:
Unipolar Depression 		0.100 GeneticVariation BEFREE Modulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on prefrontal regions in major depressive disorder. 25745134 2015
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0041696
Disease:
Unipolar Depression 		0.100 GeneticVariation BEFREE This is a systematic meta-analytical review of findings from imaging genetic studies on the impact of the rs6265 SNP on hippocampal volumes in neuropsychiatric patients with major depressive disorder, anxiety, bipolar disorder or schizophrenia. 25956254 2015
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0041696
Disease:
Unipolar Depression 		0.100 GeneticVariation BEFREE Our study aimed to clarify whether, in the presence of previous childhood maltreatment, individuals carrying low functional alleles for both SERT 5-HTTLPR and BDNF Val66Met polymorphisms had a higher risk for MD. 25510949 2015
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0041696
Disease:
Unipolar Depression 		0.100 GeneticVariation BEFREE Modulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on prefrontal regions in major depressive disorder. 25745134 2015
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0041696
Disease:
Unipolar Depression 		0.100 GeneticVariation BEFREE The current study looked at a population of patients with major depressive disorder (N = 107) to examine the association between the BDNF Val66Met polymorphism, resting state EEG alpha power, and depression severity. 23733090 2013
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0041696
Disease:
Unipolar Depression 		0.100 GeneticVariation BEFREE The current study looked at a population of patients with major depressive disorder (N = 107) to examine the association between the BDNF Val66Met polymorphism, resting state EEG alpha power, and depression severity. 23733090 2013
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0041696
Disease:
Unipolar Depression 		0.100 GeneticVariation BEFREE Common genetic variants, such as the brain-derived neurotrophic factor (BDNF) Val/66/Met polymorphism (rs6265), are known to interact with environmental factors such as early adversity to increase the risk of subsequent major depression. 22844024 2012
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0041696
Disease:
Unipolar Depression 		0.100 GeneticVariation BEFREE Recent meta-analyses point towards a pathogenic role of the Val66Met variant of the brain-derived neurotrophic factor (BDNF) in major depressive disorder, specifically in males. 22033217 2012
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0041696
Disease:
Unipolar Depression 		0.100 GeneticVariation BEFREE We found no significant association of either the BDNF G196A or MTHFR C677T polymorphisms with major depressive disorder neither in female nor male group of patients. 23255668 2012
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0041696
Disease:
Unipolar Depression 		0.100 GeneticVariation BEFREE We investigated an association between the polymorphism of brain-derived neurotrophic factor (BDNF) gene Val66Met and the response to mirtazapine in Japanese patients with major depressive disorder (MDD). 22883353 2012
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0041696
Disease:
Unipolar Depression 		0.100 GeneticVariation BEFREE Reduced fractional anisotropy in the uncinate fasciculus in patients with major depression carrying the met-allele of the Val66Met brain-derived neurotrophic factor genotype. 22585743 2012
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0041696
Disease:
Unipolar Depression 		0.100 GeneticVariation BEFREE Reduced fractional anisotropy in the uncinate fasciculus in patients with major depression carrying the met-allele of the Val66Met brain-derived neurotrophic factor genotype. 22585743 2012
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0041696
Disease:
Unipolar Depression 		0.100 GeneticVariation BEFREE We investigated an association between the polymorphism of brain-derived neurotrophic factor (BDNF) gene Val66Met and the response to mirtazapine in Japanese patients with major depressive disorder (MDD). 22883353 2012