|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our study also adds to the body of evidence associating the functional Val66Met polymorphism of BDNF with BD.
|
22085476 |
2012 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We aimed to explore whether anxiety in BD offspring was associated with the BDNF Val66Met polymorphism.64 BD offspring (mean age: 13.73 (S.D.
|
25498133 |
2015 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that BDNF G196A as well as 5HTT-LPR polymorphisms confer risk for SB in BD, but we did not observe any evidence for an interaction between them.
|
18657242 |
2008 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach.Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers.
|
28479278 |
2017 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Here we investigated a two hit gene environment model in relation to functional genomic factors (BDNF mRNA), and volume of hippocampal subfields in schizophrenia spectrum and bipolar disorders, focusing on both an environmental (childhood trauma) and genetic risk factor (BDNF val66met).
|
25246365 |
2014 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests that the markers examined thus far in COMT and SLC6A4 are not associated with pediatric bipolar disorder and that if the val66met marker in BDNF is associated with pediatric bipolar disorder the magnitude of the association is much smaller than first reported.
|
19193231 |
2009 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Assessment of the val66val BDNF allele and a range of other SNPs as potential vulnerability factors for bipolar illness and its early onset could facilitate studies of early intervention, help reduce long delays between the onset of first symptoms and the first treatment, and help in the prediction of individual patient's likelihood of responding to a given treatment.
|
17239400 |
2007 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study investigates the relationship between Val66Met polymorphisms of the BDNF gene and prefrontal cognitive function in 129 patients with schizophrenia and 111 patients with bipolar mood disorder.
|
16472361 |
2006 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A functional polymorphism Val66Met of BDNF gene was studied in patients with schizophrenia (n=336), bipolar affective disorder (n=352) and healthy controls (n=375).
|
15543516 |
2004 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The role of brain-derived neurotrophic factor (BDNF) Val66Met genetic polymorphism in bipolar disorder: a case-control study, comorbidities, and meta-analysis of 16,786 subjects.
|
25041243 |
2015 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The Val66Met polymorphism at the BDNF gene does not influence Wisconsin Card Sorting Test results in children and adolescents with bipolar disorder.
|
23567599 |
2013 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
In this preliminary analysis, SNPs in two genes, brain-derived neurotrophic factor (BDNF) and the alpha subunit of the voltage-dependent calcium channel were associated with bipolar disorder at the P<0.05 level.
|
12140781 |
2002 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
BDNF Val66Met polymorphism and bipolar disorder in European populations: A risk association in case-control, family-based and GWAS studies.
|
27236043 |
2016 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We aimed to investigate the association of NRN1 with schizophrenia-spectrum disorders (SSD) and bipolar disorders (BPD), to explore its role in age at onset and cognitive functioning, and to test the epistasis between NRN1 and BDNF.
|
26700405 |
2016 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Previous genetic studies investigating a possible involvement of variations at the brain derived neurotrophic factor (BDNF) gene locus in major depressive disorder (MDD), bipolar affective disorder (BPAD), and schizophrenia have provided inconsistent results.
|
16005437 |
2005 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Transmission/disequilibrium test (TDT) haplotype analysis showed a significant result for the 3-G allele combination (P=.000394), suggesting that a DNA variant in the vicinity of the BDNF locus confers susceptibility to BP.
|
12161822 |
2002 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The BDNF val66met polymorphism is a potential vulnerability factor for cognitive impairment in BD.
|
24862657 |
2014 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Brain-derived neurotrophic factor as a potential risk locus for bipolar disorder: evidence, limitations, and implications.
|
14609502 |
2003 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Molecular genetics studies have already identified some candidate genes; for example, the BDNF, G72 and XBP1 genes, and chromosomal 'hot spots', which may confer a predisposition to development of bipolar disorder.
|
15948763 |
2005 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Plasma BDNF concentration did not differ by val66met or BD subtype, nor was it correlated with age or illness duration.
|
24398043 |
2014 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism with early-onset bipolar disorder.
|
26528762 |
2015 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this preliminary analysis, SNPs in two genes, brain-derived neurotrophic factor (BDNF) and the alpha subunit of the voltage-dependent calcium channel were associated with bipolar disorder at the P<0.05 level.
|
12140781 |
2002 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These data do not support a role for genomic imprinting as a modifier of the contribution of BDNF gene to risk of susceptibility to BD.
|
18606495 |
2008 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The Val66Met polymorphism of the BDNF gene is unrelated to the development or clinical features of bipolar disorder, at least in a Japanese population.
|
15336520 |
2004 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Effects of the brain-derived neurotrophic growth factor val66met variation on hippocampus morphology in bipolar disorder.
|
18704093 |
2009 |