|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Since BDNF is involved in different ways in various psychiatric disorders we hypothesized that its genetic polymorphisms could be associated with the co-morbidity phenomenon in BD.
|
21167606 |
2011 |
|
Bipolar Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Schizophrenia (SZ) and bipolar disorder (BPD) patients show a downregulation of GAD67, reelin (RELN), brain-derived neurotrophic factor (BDNF), and other genes expressed in telencephalic GABAergic and glutamatergic neurons.
|
25364290 |
2014 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our study also adds to the body of evidence associating the functional Val66Met polymorphism of BDNF with BD.
|
22085476 |
2012 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
The BDNF exon I promoter methylation resulted to be significantly increased in MDD subjects compared to BD subjects (p=0.0089) and control subjects (p<0.001).
|
25106037 |
2014 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We aimed to explore whether anxiety in BD offspring was associated with the BDNF Val66Met polymorphism.64 BD offspring (mean age: 13.73 (S.D.
|
25498133 |
2015 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Sigma-1 receptor can modulate a number of central neurotransmitter systems as well as some other signaling pathways (e.g., neurotrophin and growth factor signaling) which are seemingly involved in BD and other mood disorders.
|
28144920 |
2017 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that BDNF G196A as well as 5HTT-LPR polymorphisms confer risk for SB in BD, but we did not observe any evidence for an interaction between them.
|
18657242 |
2008 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our previous work provided suggestive evidence for brain-derived neurotrophic factor (BDNF) in differentiating BD from MDD.
|
27613282 |
2017 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach.Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers.
|
28479278 |
2017 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Here we investigated a two hit gene environment model in relation to functional genomic factors (BDNF mRNA), and volume of hippocampal subfields in schizophrenia spectrum and bipolar disorders, focusing on both an environmental (childhood trauma) and genetic risk factor (BDNF val66met).
|
25246365 |
2014 |
|
Bipolar Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We conducted a systematic review and meta-analysis of all studies on serum and plasma BDNF levels in bipolar disorder.
|
26621529 |
2015 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests that the markers examined thus far in COMT and SLC6A4 are not associated with pediatric bipolar disorder and that if the val66met marker in BDNF is associated with pediatric bipolar disorder the magnitude of the association is much smaller than first reported.
|
19193231 |
2009 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Neurotrophins such as brain-derived neurotrophic factor (BDNF), inflammation and oxidative damage may contribute to the pathophysiology of bipolar disorder (BD) in terms of illness activity.
|
30808582 |
2019 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
We failed to replicate previous findings implicating BDNF in the aetiology of BPAD.
|
15274036 |
2004 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Assessment of the val66val BDNF allele and a range of other SNPs as potential vulnerability factors for bipolar illness and its early onset could facilitate studies of early intervention, help reduce long delays between the onset of first symptoms and the first treatment, and help in the prediction of individual patient's likelihood of responding to a given treatment.
|
17239400 |
2007 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Relationship between neurotrophins, especially brain-derived neurotrophic factor (BDNF) and bipolar disorder (BPD) has been widely investigated, but results have been inconsistent.
|
24308275 |
2014 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study investigates the relationship between Val66Met polymorphisms of the BDNF gene and prefrontal cognitive function in 129 patients with schizophrenia and 111 patients with bipolar mood disorder.
|
16472361 |
2006 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A functional polymorphism Val66Met of BDNF gene was studied in patients with schizophrenia (n=336), bipolar affective disorder (n=352) and healthy controls (n=375).
|
15543516 |
2004 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The role of brain-derived neurotrophic factor (BDNF) Val66Met genetic polymorphism in bipolar disorder: a case-control study, comorbidities, and meta-analysis of 16,786 subjects.
|
25041243 |
2015 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The Val66Met polymorphism at the BDNF gene does not influence Wisconsin Card Sorting Test results in children and adolescents with bipolar disorder.
|
23567599 |
2013 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
In this preliminary analysis, SNPs in two genes, brain-derived neurotrophic factor (BDNF) and the alpha subunit of the voltage-dependent calcium channel were associated with bipolar disorder at the P<0.05 level.
|
12140781 |
2002 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
BDNF Val66Met polymorphism and bipolar disorder in European populations: A risk association in case-control, family-based and GWAS studies.
|
27236043 |
2016 |
|
Bipolar Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Serum BDNF levels may not indicate high genetic risk for BD, possibly acting as state markers rather than trait markers of the disease.
|
26870912 |
2017 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We aimed to investigate the association of NRN1 with schizophrenia-spectrum disorders (SSD) and bipolar disorders (BPD), to explore its role in age at onset and cognitive functioning, and to test the epistasis between NRN1 and BDNF.
|
26700405 |
2016 |
|
Bipolar Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The change in BDNF levels between mania and remission could be adaptive and used to follow the progression of BD.
|
27138695 |
2016 |