|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
In this preliminary analysis, SNPs in two genes, brain-derived neurotrophic factor (BDNF) and the alpha subunit of the voltage-dependent calcium channel were associated with bipolar disorder at the P<0.05 level.
|
12140781 |
2002 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Transmission/disequilibrium test (TDT) haplotype analysis showed a significant result for the 3-G allele combination (P=.000394), suggesting that a DNA variant in the vicinity of the BDNF locus confers susceptibility to BP.
|
12161822 |
2002 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this preliminary analysis, SNPs in two genes, brain-derived neurotrophic factor (BDNF) and the alpha subunit of the voltage-dependent calcium channel were associated with bipolar disorder at the P<0.05 level.
|
12140781 |
2002 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
LHGDN |
Transmission/disequilibrium test (TDT) haplotype analysis showed a significant result for the 3-G allele combination (P=.000394), suggesting that a DNA variant in the vicinity of the BDNF locus confers susceptibility to BP.
|
12161822 |
2002 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Brain-derived neurotrophic factor as a potential risk locus for bipolar disorder: evidence, limitations, and implications.
|
14609502 |
2003 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Several reports have suggested that the BDNF gene is a plausible functional candidate gene underlying the predisposition for developing bipolar disorder (BPD).
|
12524161 |
2003 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
We failed to replicate previous findings implicating BDNF in the aetiology of BPAD.
|
15274036 |
2004 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A functional polymorphism Val66Met of BDNF gene was studied in patients with schizophrenia (n=336), bipolar affective disorder (n=352) and healthy controls (n=375).
|
15543516 |
2004 |
|
Bipolar Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Drug-induced decrease of protein kinase a activity reveals alteration in BDNF expression of bipolar affective disorder.
|
14735135 |
2004 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The Val66Met polymorphism of the BDNF gene is unrelated to the development or clinical features of bipolar disorder, at least in a Japanese population.
|
15336520 |
2004 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
CTD_human |
Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium.
|
14708030 |
2004 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The BDNF (GT)(n) marker and the val/short haplotype are associated with COMD in this sample, in accordance with the previously described neurotrophic hypothesis of depression and some previous studies of association for bipolar disorder and neuroticism.
|
15384083 |
2004 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Previous genetic studies investigating a possible involvement of variations at the brain derived neurotrophic factor (BDNF) gene locus in major depressive disorder (MDD), bipolar affective disorder (BPAD), and schizophrenia have provided inconsistent results.
|
16005437 |
2005 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Molecular genetics studies have already identified some candidate genes; for example, the BDNF, G72 and XBP1 genes, and chromosomal 'hot spots', which may confer a predisposition to development of bipolar disorder.
|
15948763 |
2005 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Recent studies have indicated that the brain-derived neurotrophic factor (BDNF) gene is involved in the etiology of bipolar disorder (BPD).
|
16152572 |
2005 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
There is also growing evidence for the role of DRD1, NMDA receptor genes (GRIN1, GRIN2A, GRIN2B), brain-derived neurotrophic factor (BDNF), and dopamine transporter (SLC6A3) in both schizophrenia and bipolar disorder.
|
15952869 |
2005 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
BDNF gene is a risk factor for schizophrenia in a Scottish population.
|
15630410 |
2005 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
For bipolar disorder the strongest evidence supports DAOA(G72) and BDNF.
|
15744031 |
2005 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Brain-derived neurotrophic factor (BDNF) has been involved in the pathogenesis of bipolar mood disorder and in the mechanism of mood-normalizing action of lithium.
|
16025419 |
2005 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study investigates the relationship between Val66Met polymorphisms of the BDNF gene and prefrontal cognitive function in 129 patients with schizophrenia and 111 patients with bipolar mood disorder.
|
16472361 |
2006 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Transmission distortion of BDNF variants to bipolar disorder type I patients from a South American population isolate.
|
16741941 |
2006 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Our results suggest that the BDNF-LCPR is a functional variation that confers susceptibility to bipolar disorder and affects transcriptional activity of the BDNF gene.
|
16568151 |
2006 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Incorporating this clinical sub-phenotyping into other studies of the BDNF gene may help to resolve some of the inconsistencies reported thus far concerning BDNF and bipolar disorder.
|
17012654 |
2006 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Variation at the Val66Met polymorphism of BDNF does not play a major role in influencing susceptibility to bipolar disorder as a whole, but is associated with susceptibility to the rapid-cycling subset of the disorder.
|
16388065 |
2006 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A significant association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder has been reported.
|
16538178 |
2006 |