Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data suggest that BDNF and its receptor may play a local role within the hippocampus in kindling-associated neural plasticity and in neuronal protection following epileptic, ischemic, and hypoglycemic insults.
|
8439408 |
1993 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
There also was a significant negative correlation between the duration of epilepsy and the expression of mRNA for brain-derived neurotrophic factor.
|
10713570 |
2000 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
As nerve growth factor and brain derived neurotrophic factor are the best-studied proteins of this class, we begin by discussing the evidence linking these neurotrophins to epilepsy and seizure.
|
11124444 |
2001 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
CTD_human |
Together, these results suggest that dendritic accumulation of BDNF mRNA and protein plays a critical role in the cellular changes leading to epilepsy.
|
15282290 |
2004 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
Pathologic levels of BDNF-dependent synaptic plasticity may contribute to conditions such as epilepsy and chronic pain sensitization, whereas application of the trophic properties of BDNF may lead to novel therapeutic options in neurodegenerative diseases and perhaps even in neuropsychiatric disorders.
|
15518235 |
2004 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
What is the biological significance of BDNF mRNA targeting in the dendrites? Clues from epilepsy and cortical development.
|
16388108 |
2006 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
BDNF has emerged as one of the most important signaling molecules for the developing nervous system as well as the impaired nervous system, and multiple diseases, such as Alzheimer's, Parkinson's, Huntington's, epilepsy, Rett's syndrome, and psychiatric depression, are linked by their association with potential dysregulation of BDNF-driven signal transduction programs.
|
18208542 |
2008 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We report that the seizure-induced decrease in GABA(A)R alpha1 subunit expression associated with epilepsy is mediated by the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway regulated by brain-derived neurotrophic factor (BDNF).
|
18922788 |
2008 |
Epilepsy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Abnormalities in BDNF-mediated plasticity are shown in FXS and the present data suggest that the Met66 allele might predispose FXS males to epilepsy.
|
19394799 |
2009 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
The highly integrated layers of the epigenome are responsible for the cell type specific and exquisitely environmentally responsive deployment of genes and functional gene networks that underlie the molecular pathophysiology of epilepsy and its associated comorbidities, including but not limited to neurotransmitter receptors (e.g., GluR2, GLRA2, and GLRA3), growth factors (e.g., BDNF), extracellular matrix proteins (e.g., RELN), and diverse transcriptional regulators (e.g., CREB, c-fos, and c-jun).
|
20188170 |
2010 |
Epilepsy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Epilepsy is frequent and has been reported to correlate with mutation type, general disease severity, and BDNF polymorphism.
|
20491871 |
2010 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
We assessed plasma [corrected] BDNF immunoreactivity in 15 patients with ES, 12 patients with PNES, and 17 healthy volunteers.
|
20921514 |
2010 |
Epilepsy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Predisposition to epilepsy in fragile X syndrome: does the Val66Met polymorphism in the BDNF gene play a role?
|
21890420 |
2011 |
Epilepsy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We identified a novel intragenic deletion of maternal origin in two siblings with mild ID and epilepsy in the CADPS2 gene, encoding for a synaptic protein involved in neurotrophin release and interaction with dopamine receptor type 2 (D2DR).
|
24737869 |
2014 |
Epilepsy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our results suggest that BDNF polymorphisms might contribute to the risk of epilepsy in Malaysian Indians and Chinese.
|
25876511 |
2016 |
Epilepsy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, whether BDNF Val66Met polymorphism is associated with epilepsy remains controversial.
|
26000807 |
2016 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
A putative role of the brain-derived neurotrophic factor (BDNF) in epilepsy has emerged from in vitro and animal models, but few studies have analyzed human samples.
|
26621122 |
2016 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
We investigated the influence of variants in the genes encoding neuron-restrictive silencer factor (NRSF) and brain-derived neurotrophic factor (BDNF), proteins previously associated with cognition and epilepsy, on cognitive function in people with newly diagnosed epilepsy.
|
26708060 |
2016 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We aimed to determine whether a common polymorphism of the brain-derived neurotrophic factor (BDNF), which constitutes an important and ubiquitously expressed neurotrophine in the brain, affects the stimulation threshold of ECTs required to induce an epileptic seizure over time.
|
27787610 |
2017 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
BDNF levels and ERK and mTOR activation were decreased in rats with epilepsy and resistance exercise restored these to control levels.
|
28078614 |
2017 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, an obvious decrease in the PSD95 and BDNF expression levels of epileptic A1R KO mice was observed 7 days after complete kindling.
|
28492982 |
2018 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
We also assayed the cyclic adenosine monophosphate response element-binding (CREB) and glucocorticoid receptor (GR) genes as there is experimental evidence of changes in their expression associated with BDNF and epilepsy.
|
28527108 |
2018 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The expression of brain-derived neurotrophic factor (BDNF) in the CA3 area of the hippocampus in the comorbidity group was significantly higher than that in the epilepsy group according to the immunohistochemical test (P<0.05).
|
28559979 |
2017 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Rats with epilepsy presented decreased BDNF levels compared with control rats.
|
29098710 |
2018 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The present results demonstrated that inhibition of Kir4.1 channels facilitates BDNF expression in astrocytes primarily by activating the Ras/Raf/MEK/ERK pathway, which may be linked to the development of epilepsy and other neuropsychiatric disorders.
|
29358904 |
2017 |