|
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
<b>Background:</b> Brain-derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1) may regulate the autonomic nervous system (ANS) in epilepsy.
|
30524358 |
2018 |
|
Epilepsy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Epilepsy is frequent and has been reported to correlate with mutation type, general disease severity, and BDNF polymorphism.
|
20491871 |
2010 |
|
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
BDNF has emerged as one of the most important signaling molecules for the developing nervous system as well as the impaired nervous system, and multiple diseases, such as Alzheimer's, Parkinson's, Huntington's, epilepsy, Rett's syndrome, and psychiatric depression, are linked by their association with potential dysregulation of BDNF-driven signal transduction programs.
|
18208542 |
2008 |
|
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
BDNF levels and ERK and mTOR activation were decreased in rats with epilepsy and resistance exercise restored these to control levels.
|
28078614 |
2017 |
|
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
A putative role of the brain-derived neurotrophic factor (BDNF) in epilepsy has emerged from in vitro and animal models, but few studies have analyzed human samples.
|
26621122 |
2016 |
|
Epilepsy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Abnormalities in BDNF-mediated plasticity are shown in FXS and the present data suggest that the Met66 allele might predispose FXS males to epilepsy.
|
19394799 |
2009 |
|
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although the full agonist effects of brain-derived neurotrophic factor and tropomyosin receptor kinase B activation in epilepsy models have been controversial, the present results indicate that such trophic activation by a partial agonist may potentially serve as an effective therapeutic option for prophylactic treatment of posttraumatic epileptogenesis, and treatment of other neurological and psychiatric disorders whose pathogenesis involves impaired parvalbumin interneuronal function.
|
29408225 |
2018 |
|
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
As nerve growth factor and brain derived neurotrophic factor are the best-studied proteins of this class, we begin by discussing the evidence linking these neurotrophins to epilepsy and seizure.
|
11124444 |
2001 |
|
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Compared with miR-103a inhibitors alone, epilepsy rats treated with BDNF-siRNA combined with miR-103a inhibitors significantly increased expression of GFAP in hippocampal tissues of epilepsy rats, increased number of apoptotic neurons and significantly decreased the number of surviving neurons.
|
31049031 |
2019 |
|
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Downregulated hippocampal expression of brain derived neurotrophic factor and tyrosine kinase B in a rat model of comorbid epilepsy and depression.
|
30741614 |
2019 |
|
Epilepsy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, whether BDNF Val66Met polymorphism is associated with epilepsy remains controversial.
|
26000807 |
2016 |
|
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, an obvious decrease in the PSD95 and BDNF expression levels of epileptic A1R KO mice was observed 7 days after complete kindling.
|
28492982 |
2018 |
|
Epilepsy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our results suggest that BDNF polymorphisms might contribute to the risk of epilepsy in Malaysian Indians and Chinese.
|
25876511 |
2016 |
|
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this review article, we discuss recent finding illuminating how mBDNF-TrkB and proBDNF-p75<sup>NTR</sup> signaling pathways regulate GABA related neurotransmission under physiological conditions and during epilepsy.
|
30210299 |
2018 |
|
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that the protection against neuronal loss in specific limbic regions and overexpressed BDNF in the mossy fibers resulting from the repeated treatment with Ago and LCM, respectively, during SE is not a prerequisite for alleviation of epileptogenesis and development of epilepsy.
|
30738136 |
2019 |
|
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
Pathologic levels of BDNF-dependent synaptic plasticity may contribute to conditions such as epilepsy and chronic pain sensitization, whereas application of the trophic properties of BDNF may lead to novel therapeutic options in neurodegenerative diseases and perhaps even in neuropsychiatric disorders.
|
15518235 |
2004 |
|
Epilepsy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Predisposition to epilepsy in fragile X syndrome: does the Val66Met polymorphism in the BDNF gene play a role?
|
21890420 |
2011 |
|
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Rats with epilepsy presented decreased BDNF levels compared with control rats.
|
29098710 |
2018 |
|
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Silencing lncRNA PVT1 inhibits activation of astrocytes and increases BDNF expression in hippocampus tissues of rats with epilepsy by downregulating the Wnt signaling pathway.
|
30805931 |
2019 |
|
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
The current review is an attempt to collate the available preclinical and clinical studies to establish the therapeutic potential of various dietary flavonoids in comprehensive management of epilepsy with relation to CREB-BDNF pathway.
|
31400269 |
2019 |
|
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The expression of brain-derived neurotrophic factor (BDNF) in the CA3 area of the hippocampus in the comorbidity group was significantly higher than that in the epilepsy group according to the immunohistochemical test (P<0.05).
|
28559979 |
2017 |
|
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
The highly integrated layers of the epigenome are responsible for the cell type specific and exquisitely environmentally responsive deployment of genes and functional gene networks that underlie the molecular pathophysiology of epilepsy and its associated comorbidities, including but not limited to neurotransmitter receptors (e.g., GluR2, GLRA2, and GLRA3), growth factors (e.g., BDNF), extracellular matrix proteins (e.g., RELN), and diverse transcriptional regulators (e.g., CREB, c-fos, and c-jun).
|
20188170 |
2010 |
|
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The present results demonstrated that inhibition of Kir4.1 channels facilitates BDNF expression in astrocytes primarily by activating the Ras/Raf/MEK/ERK pathway, which may be linked to the development of epilepsy and other neuropsychiatric disorders.
|
29358904 |
2017 |
|
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
There also was a significant negative correlation between the duration of epilepsy and the expression of mRNA for brain-derived neurotrophic factor.
|
10713570 |
2000 |
|
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thereafter, we discuss aspiring strategies for targeting BDNF/TrkB signaling so as to prevent epilepsy following an insult or suppress its expression once developed.
|
31377199 |
2020 |