|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
These findings provide evidence of the important role of early cannabis use and the Val66Met BDNF polymorphism on age at psychosis onset and they point out to sex-specific differences in cannabis use patterns.
|
28142064 |
2017 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Finally, we observe that frontal-cortex DNA methylation in the BDNF gene is correlated with genotype at a nearby nonsynonymous SNP that has been previously associated with major psychosis.
|
18319075 |
2008 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
To begin to address this issue, we conducted high-coverage targeted exome capture in a subset of neurotrophin genes in 48 comprehensively characterized cases with schizophrenia-related psychosis.
|
26215504 |
2015 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Brain derived neurotrophic factor (BDNF) is important for brain development and plasticity, and here we tested if the functional BDNF val66met variant modulates the association between high levels of childhood abuse, cognitive function, and brain abnormalities in psychoses.
|
23876786 |
2013 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Chronic methamphetamine interacts with BDNF Val66Met to remodel psychosis pathways in the mesocorticolimbic proteome.
|
31822818 |
2019 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
There was no difference in the proportion of Met allele carriers between FEP patients and controls, and no significant influence of BDNF genotype on cognitive test scores in either of the psychosis groups.
|
23429848 |
2012 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
COMT, D4 receptor, and BDNF polymorphisms are linked to methamphetamine abuse and psychosis.
|
19462300 |
2009 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
This study aimed to investigate the degree of DNA methylation at the promoter region of the brain-derived neurotrophic factor (BDNF) gene, as one of the candidate genes associated with major psychoses, in peripheral blood mononuclear cells isolated from 94 patients with BD (BD I=49, BD II=45) and 52 healthy controls.
|
22353757 |
2012 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The present study aimed to explore possible effects of BDNF Val66Met polymorphism variations on progressive structural brain changes after 3 years from the first episode of psychosis.
|
23748016 |
2013 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In this first phase of the project, the objective was to investigate the distribution of four candidate genetic polymorphisms for functional psychosis (Ser9Gly DRD3, 5HTTLPR, the VNTR 3'-UTR SLC6A3 and Val66Met BDNF) in a case-control sample.
|
19142409 |
2008 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
No compelling evidence was found that BDNF genotype is associated with age at onset of psychotic disorder in the absence of cannabis use.
|
21305693 |
2011 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The results had adequate statistical power to suggest that BDNF Val66Met was not related to susceptibility to AD or the onset of AD, but that presence of one or two Met alleles of BDNF Val66Met polymorphism might present a risk factor for psychosis in AD.
|
21044653 |
2011 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A complex interplay between BDNF serum concentrations, personality traits, BDNF Val66Met polymorphism, and psychotic symptomatology has been arisen but further investigation is needed to better clarify the observed associations.
|
23333821 |
2013 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The Met allele of the functional polymorphism, BDNF Val66Met, is associated with psychotic disorders.
|
21728904 |
2012 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Clinical features of psychotic disorders and polymorphisms in HT2A, DRD2, DRD4, SLC6A3 (DAT1), and BDNF: a family based association study.
|
14755448 |
2004 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Trend level gene-gender interaction effect for the BDNF rs6265 variant on age of onset of psychosis.
|
31445421 |
2019 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Further, our study supports a two hit model including a history of childhood trauma as well as genetic vulnerability (met carriers of the BDNF val66met) behind reduced volume of hippocampal subfields in psychosis.
|
25246365 |
2014 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The BDNF-Val66Met polymorphism may index susceptibility to expression of psychosis along a spectrum.
|
29785763 |
2019 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our results showed that the distribution of the BDNF Val66Met genotype in Chinese subjects with methamphetamine dependence (OR=2.6, p=0.015) and methamphetamine psychosis (OR=0.2, p = 0.034) were significant compared with controls.
|
20736000 |
2010 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Preliminary evidence suggests that polymorphisms within the catechol-O-methyltransferase and brain-derived neurotrophic factor genes may interact with psychosocial stress in the development of psychosis; however, extensive further investigations are required to confirm this.
|
18718885 |
2008 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Do COMT, BDNF and NRG1 polymorphisms influence P50 sensory gating in psychosis?
|
20102668 |
2011 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
One of the most studied genetic phenotypes for psychosis is brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms.
|
26603624 |
2016 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The three-way pICA approach identified links between a SNP component (pointing to brain function and mental disorder associated genes, including BDNF, GRIN2B and NRG1), a functional component related to increased activation in the precuneus area, and a gray matter component comprising part of the default mode network and the caudate.
|
24795156 |
2014 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our finding suggests that the investigated BDNF polymorphism plays an important role in the phenotype of psychosis, but not in the performance of tests of prefrontal cognitive functions analyzed in these patients.
|
16389585 |
2006 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We aimed to investigate whether there is a gene-environment interaction in the relationship between stress and BDNF Val66Met polymorphism in relation to dietary patterns in a sample of subjects with early psychosis.
|
27629407 |
2018 |