|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Clinical features of psychotic disorders and polymorphisms in HT2A, DRD2, DRD4, SLC6A3 (DAT1), and BDNF: a family based association study.
|
14755448 |
2004 |
|
Psychotic Disorders
|
0.400 |
Biomarker
|
group |
CTD_human |
Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium.
|
14708030 |
2004 |
|
Psychotic Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Brain-derived neurotrophic factor (BDNF) has been implicated in cognitive functions and in the pathogenesis of major psychoses.
|
16472361 |
2006 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our finding suggests that the investigated BDNF polymorphism plays an important role in the phenotype of psychosis, but not in the performance of tests of prefrontal cognitive functions analyzed in these patients.
|
16389585 |
2006 |
|
Psychotic Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
A larger sample size, and evaluation of more single-nucleotide polymorphisms are needed to obtain more robust and conclusive findings regarding the relationship between the BDNF gene and psychosis.
|
17417060 |
2007 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Finally, we observe that frontal-cortex DNA methylation in the BDNF gene is correlated with genotype at a nearby nonsynonymous SNP that has been previously associated with major psychosis.
|
18319075 |
2008 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In this first phase of the project, the objective was to investigate the distribution of four candidate genetic polymorphisms for functional psychosis (Ser9Gly DRD3, 5HTTLPR, the VNTR 3'-UTR SLC6A3 and Val66Met BDNF) in a case-control sample.
|
19142409 |
2008 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Preliminary evidence suggests that polymorphisms within the catechol-O-methyltransferase and brain-derived neurotrophic factor genes may interact with psychosocial stress in the development of psychosis; however, extensive further investigations are required to confirm this.
|
18718885 |
2008 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
COMT, D4 receptor, and BDNF polymorphisms are linked to methamphetamine abuse and psychosis.
|
19462300 |
2009 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our results showed that the distribution of the BDNF Val66Met genotype in Chinese subjects with methamphetamine dependence (OR=2.6, p=0.015) and methamphetamine psychosis (OR=0.2, p = 0.034) were significant compared with controls.
|
20736000 |
2010 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
No compelling evidence was found that BDNF genotype is associated with age at onset of psychotic disorder in the absence of cannabis use.
|
21305693 |
2011 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The results had adequate statistical power to suggest that BDNF Val66Met was not related to susceptibility to AD or the onset of AD, but that presence of one or two Met alleles of BDNF Val66Met polymorphism might present a risk factor for psychosis in AD.
|
21044653 |
2011 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Do COMT, BDNF and NRG1 polymorphisms influence P50 sensory gating in psychosis?
|
20102668 |
2011 |
|
Psychotic Disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Peripheral BDNF levels have been found altered in first-episode patients with psychosis and also in chronic schizophrenia patients.
|
21248641 |
2011 |
|
Psychotic Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
These data do not support a role for allelic imbalance or POE of BDNF for suicidal behaviour in major psychoses.
|
20726824 |
2011 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
There was no difference in the proportion of Met allele carriers between FEP patients and controls, and no significant influence of BDNF genotype on cognitive test scores in either of the psychosis groups.
|
23429848 |
2012 |
|
Psychotic Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Hippocampal volume and BDNF genotyping were obtained for 58 patients with first-episode psychosis and 39 healthy volunteers.
|
22192502 |
2012 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
This study aimed to investigate the degree of DNA methylation at the promoter region of the brain-derived neurotrophic factor (BDNF) gene, as one of the candidate genes associated with major psychoses, in peripheral blood mononuclear cells isolated from 94 patients with BD (BD I=49, BD II=45) and 52 healthy controls.
|
22353757 |
2012 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The Met allele of the functional polymorphism, BDNF Val66Met, is associated with psychotic disorders.
|
21728904 |
2012 |
|
Psychotic Disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
A negative correlation was also observed between duration of psychosis and plasma BDNF levels.
|
22213405 |
2012 |
|
Psychotic Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The brain-derived neurotrophic factor (BDNF) is a key regulator of synaptic plasticity and has been suggested to be involved in the pathophysiology and pathogenesis of psychotic disorders, with particular emphasis on dysfunctions of the hippocampus.
|
21509595 |
2012 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Brain derived neurotrophic factor (BDNF) is important for brain development and plasticity, and here we tested if the functional BDNF val66met variant modulates the association between high levels of childhood abuse, cognitive function, and brain abnormalities in psychoses.
|
23876786 |
2013 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The present study aimed to explore possible effects of BDNF Val66Met polymorphism variations on progressive structural brain changes after 3 years from the first episode of psychosis.
|
23748016 |
2013 |
|
Psychotic Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A complex interplay between BDNF serum concentrations, personality traits, BDNF Val66Met polymorphism, and psychotic symptomatology has been arisen but further investigation is needed to better clarify the observed associations.
|
23333821 |
2013 |
|
Psychotic Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The current, limited evidence points to genes that are not specifically involved in psychosis but more generally in regulating mood (serotonin transporter gene), neuroplasticity (brain-derived neurotrophic factor), and the stress-response system (FKBP5), in line with a general effect of CT on a range of mental disorders, rather than suggesting specificity for psychosis.
|
23327756 |
2013 |