|
Coronary Artery Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease.
|
19660754 |
2010 |
|
Coronary Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We also identify SORT1 and CELSR2 as candidate susceptibility genes for a locus recently associated with coronary artery disease and plasma low-density lipoprotein cholesterol levels in the process.
|
18462017 |
2008 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We also identify SORT1 and CELSR2 as candidate susceptibility genes for a locus recently associated with coronary artery disease and plasma low-density lipoprotein cholesterol levels in the process.
|
18462017 |
2008 |
|
Cardiovascular Diseases
|
0.380 |
GeneticVariation
|
group |
BEFREE |
Studies of sortilin's influence on cardiovascular and metabolic diseases goes far beyond the genome-wide association studies that have revealed an association between cardiovascular diseases and the 1p13 locus that encodes sortilin.
|
29191923 |
2018 |
|
Cardiovascular Diseases
|
0.380 |
Biomarker
|
group |
BEFREE |
Together our findings support a novel role of Sortilin in energy regulation and lipid homeostasis in female mice, which may be a potential therapeutic target for obesity and cardiovascular disease.
|
29899496 |
2018 |
|
Cardiovascular Diseases
|
0.380 |
Biomarker
|
group |
BEFREE |
Sortilin-1, a receptor of the VPS10p family, has been associated with cardiovascular disease in genome-wide association studies.
|
28742217 |
2017 |
|
Cardiovascular Diseases
|
0.380 |
Biomarker
|
group |
BEFREE |
The fact that SORT1 has been strongly associated with risk of cardiovascular disease is intriguing as cardiovascular disease is also regarded as a risk factor for AD.
|
27392867 |
2016 |
|
Cardiovascular Diseases
|
0.380 |
GeneticVariation
|
group |
BEFREE |
Primary outcome of interest was incident hard CVD (myocardial infarction, stroke, and cardiovascular death); interaction between proneurotensin concentration with sex, low-density lipoprotein concentrations, and sortilin receptor 1 single-nucleotide polymorphisms was sought.
|
27312221 |
2016 |
|
Cardiovascular Diseases
|
0.380 |
Biomarker
|
group |
BEFREE |
Sortilin seems to play an important role in the development of cardiovascular disease and have functions beyond regulating LDL-cholesterol.
|
25702058 |
2015 |
|
Cardiovascular Diseases
|
0.380 |
Biomarker
|
group |
CTD_human |
Genetic variation of SORT1 was strongly associated with cardiovascular disease risk in humans.
|
25805502 |
2015 |
|
Cardiovascular Diseases
|
0.380 |
GeneticVariation
|
group |
BEFREE |
These results provide evidence of decreased exposure to atherogenic particles in carriers of the minor SORT1 allele, suggesting relative protection against cardiovascular disease when compared with TT homozygotes.
|
25042869 |
2014 |
|
Cardiovascular Diseases
|
0.380 |
Biomarker
|
group |
BEFREE |
Sortilin and the risk of cardiovascular disease.
|
23910371 |
2013 |
|
Liver diseases
|
0.310 |
Biomarker
|
group |
CTD_human |
Finally, we found that liver Sort1 was repressed after BDL, which may be due to BA activation of farnesoid x receptor.
|
28453831 |
2018 |
|
Liver diseases
|
0.310 |
Biomarker
|
group |
BEFREE |
This study further suggests that therapeutic inhibition of SORT1 may be beneficial in improving hepatic cholesterol homeostasis in metabolic and inflammatory liver diseases.
|
27881673 |
2017 |
|
Cholestasis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Sortilin 1 Loss-of-Function Protects Against Cholestatic Liver Injury by Attenuating Hepatic Bile Acid Accumulation in Bile Duct Ligated Mice.
|
28453831 |
2018 |
|
Liver Dysfunction
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Sortilin 1 Loss-of-Function Protects Against Cholestatic Liver Injury by Attenuating Hepatic Bile Acid Accumulation in Bile Duct Ligated Mice.
|
28453831 |
2018 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Epistasis Project: A Multi-Cohort Study of the Effects of BDNF, DBH, and SORT1 Epistasis on Alzheimer's Disease Risk.
|
30909233 |
2019 |
|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sortilin enhances lysosomal degradation of ABCA1 protein and suppresses ABCA1-mediated cholesterol efflux from macrophages, leading to foam cell formation and AS development.
|
30950489 |
2019 |
|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We showed that sortilin is significantly and independently associated with the presence of lower limb PAD in a statin-free diabetic population and it may be a promising marker for clinically significant atherosclerosis of the lower limbs.
|
30634965 |
2019 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sortilin enhances lysosomal degradation of ABCA1 protein and suppresses ABCA1-mediated cholesterol efflux from macrophages, leading to foam cell formation and AS development.
|
30950489 |
2019 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We showed that sortilin is significantly and independently associated with the presence of lower limb PAD in a statin-free diabetic population and it may be a promising marker for clinically significant atherosclerosis of the lower limbs.
|
30634965 |
2019 |
|
Glomerular Filtration Rate
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis.
|
31015462 |
2019 |
|
Alzheimer's Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this minireview, we update some latest findings from animal experiments and human brain studies suggesting that abnormal sortilin expression is associated with AD-type neuropathology, warranting further research that might lead to novel targets for the development of AD therapies.
|
29687731 |
2018 |
|
Alzheimer's Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we first found that the protein level of sortilin was up-regulated in the neocortex of aged (7 and 9months old) but not young (2 and 5months old) AD mice (APP/PS1).
|
29056359 |
2018 |
|
Alzheimer's Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Induction of apoptosis and p75 ICD internalization by AD patients-derived proBDNF is further enhanced in neuron cultures from the AD model expressing the APP/PS1∆E9 transgene.Our results indicate the importance of proBDNF neurotoxic signaling in AD pathology essentially by three mechanisms: i) by an increase of proBDNF stability due to ROS-induced post-traductional modifications; ii) by the increase of expression of the p75 co-receptor, Sortilin and iii) by the increase of the basal levels of p75 processing found in AD.
|
30428894 |
2018 |