|
Pancytopenia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Among 1718 allo-HSCT, 74% were performed for malignancy (ALL 47.2%, AML 26.2%, MDS 10.8%, CML 8.1%, NHL/HD 6.1%, others 2.5%), and 26% for non-malignant disorders (SAA 41%, congenital immunodeficiencies 35.4%, hereditary bone marrow failure 16%, metabolic disorders 7%).
|
29880247 |
2018 |
|
polyps
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
When the polyp SAA protein level was 122.2 ng/ml or higher, the sensitivity and specificity were 76.92 and 73.68%, respectively.
|
29177948 |
2018 |
|
Adult-Onset Still Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Also, there was no significant difference in SAA1 -13C/T allele frequency between AOSD patients with and without MEFV mutations.Our data shows a significant association between T allele of rs12218 and AOSD in Japanese population.
|
30544414 |
2018 |
|
Autism Spectrum Disorders
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
High (top quartile) concentrations of SAA are associated with elevated risk of ASD (2.8; 1.2-6.7) when Ang-1 concentrations are below the top quartile, but not when Ang-1 concentrations are high (1.3; 0.3-5.8).
|
29884819 |
2018 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings support the concept that selective inhibition of SAA1 in CAFs may provide potential therapeutic benefit to PDAC patients.
|
29351990 |
2018 |
|
ATRIAL SEPTAL DEFECT 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
ASD (N = 36) assessed at age 10 years is associated with recurrent top quartile concentrations of inflammation-related proteins during the first post-natal month (e.g., SAA odds ratio (OR); 95% confidence interval (CI): 2.5; 1.2-5.3) and IL-6 (OR; 95% CI: 2.6; 1.03-6.4)).
|
29884819 |
2018 |
|
Asthma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
ALX expression and levels of proresolving ligands (lipoxin A4 [LXA4], 15-epi-LXA4, and annexin A1 [ANXA1]), and a proinflammatory ligand (serum amyloid A [SAA]) were measured in bronchoscopy samples collected in Severe Asthma Research Program-3 (SA [n = 69], non-SA [NSA, n = 51] or healthy donors [HDs, n = 47]).
|
28724795 |
2017 |
|
Astrocytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Quantitative real time PCR (qRT-PCR) of 148 astrocytomas samples (grades I-IV) showed that SAA1 mRNA was significantly higher in GBM when compared to AGI-III and NN samples (p < 0.0001).
|
28283801 |
2017 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
More importantly, several three-protein combinations that contain OPN and CEA plus one of four proteins (CRP, SAA, CYFRA21.1 or NSE) have excellent diagnostic potential for NSCLC (AUC = 0.96).
|
28121629 |
2017 |
|
Cytomegalovirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Thus, we measured 21 serum proteins related to HCMV infection using iTRAQ-labeling based quantitative proteomic approaches and SAA1 and APOE were confirmed as candidate serum indicators for identification of HMCV infection according to ROC curve analysis and that co-occurrence of SAA1 and APOE are better markers than individual proteins.
|
29042594 |
2017 |
|
Mental Depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, the SAA1 TG mouse model is a valuable model to study depression.
|
27608955 |
2017 |
|
Depressive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, the SAA1 TG mouse model is a valuable model to study depression.
|
27608955 |
2017 |
|
Dermatitis, Atopic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Human skins and sera were obtained from patients with psoriasis and AD.A-SAA mRNA was quantified by RT qPCR.
|
28708859 |
2017 |
|
Eczema
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Human skins and sera were obtained from patients with psoriasis and AD.A-SAA mRNA was quantified by RT qPCR.
|
28708859 |
2017 |
|
Fuchs Endothelial Dystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Higher percentages of stromal cells in FECD versus normal stained for αSMA (OR = 864.26, P < 0.001), brain-derived neurotrophic factor (BDNF, OR = 6.34, P = 0.005), fibroblast growth factor 7 (FGF-7, OR = 2.76, P = 0.011), FGF-9 (OR = 5.97, P < 0.001), receptor FGFR-3 (OR = 13.90, P = < 0.001), and serum amyloid A1 (OR = 3.45, P = 0.023).
|
28481834 |
2017 |
|
Pain in limb
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Pro-inflammatory mediators including tumor necrosis factor (TNF)-α, TNF-β, interleukin (IL)-8, ICAM-1, Tie2, CRP, and SAA were elevated in patients with chronic residual limb pain.
|
27682210 |
2017 |
|
Sarcoidosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our objective was to determine the diagnostic specificity of SAA staining for sarcoidosis relative to other granulomatous disorders.
|
28427539 |
2017 |
|
Small cell carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Eight of the 11 proteins (OPN, SAA, CRP, CYFRA21.1, CEA, NSE, AGP and HGF) are significantly elevated in NSCLC and SCLC (p = 10-5-10-59).
|
28121629 |
2017 |
|
Intestinal infectious disease (disorder)
|
0.010 |
AlteredExpression
|
group |
BEFREE |
However, we observed that the functional expression of MyD88 in intestinal epithelial cells (IEC) also partially protected the mice during intestinal infection, which was associated with enhanced epithelial barrier integrity and increased expression of the antimicrobial peptide RegIIIγ and the acute phase protein SAA1 by epithelial cells.
|
28520792 |
2017 |
|
Fibrillation
|
0.010 |
Biomarker
|
disease |
BEFREE |
The formed amyloid becomes deposited outside the cell where it can seed the fibrillation of extracellular SAA1.
|
28637682 |
2017 |
|
Acquired aplastic anemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We enrolled 71 patients with acquired AA (36 severe AA cases [SAA] and 35 non-severe AA cases [NSAA]) and 42 healthy volunteers.
|
28831064 |
2017 |
|
Depressed mood
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, the SAA1 TG mouse model is a valuable model to study depression.
|
27608955 |
2017 |
|
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, we also showed that serum amyloid A1 (SAA1) play a vital role in FAO, ATP and cell growth promoted by Sun2 loss in prostate cancer.
|
29163775 |
2017 |
|
Prostate carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, we also showed that serum amyloid A1 (SAA1) play a vital role in FAO, ATP and cell growth promoted by Sun2 loss in prostate cancer.
|
29163775 |
2017 |
|
Ischemic stroke
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The present study is aimed to evaluate whether the SAA gene polymorphism is involved in ischemic stroke in northern Chinese Han population.
|
28870546 |
2017 |