|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Overall, we found no significant association between MCP-1 -2518A>G polymorphism and asthma susceptibility in any of the genetic model comparisons.
|
31664304 |
2019 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this cohort of children, there are associations between carrying G at -2518 of the MCP-1 gene regulatory region and the presence of asthma as well as between asthma severity and homozygosity for the G allele.
|
11544456 |
2001 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No association was observed between the four polymorphisms and the presence of atopic rhinitis or atopic conjunctivitis and an elevated rate of serum IgE over 200 IU/ml.Additional effects of MCP-1 and its receptor CCR2 polymorphisms seem to be involved in disease susceptibility to asthma in Tunisian patients; nevertheless they could be protective against its severe forms.
|
23454776 |
2013 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The finding in the family study that the CCL2-2578G allele was transmitted less often by heterozygous parents to their children with asthma (P=0.0016) confirms the association of CCL2-2578G with asthma risk.
|
18615095 |
2008 |
|
Coronary Arteriosclerosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association of monocyte chemoattractant protein-1 (MCP-1)-2518A>G polymorphism with susceptibility to coronary artery disease: a meta-analysis.
|
25875728 |
2015 |
|
Coronary Arteriosclerosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A monocyte chemoattractant protein-1 gene polymorphism is not associated with coronary artery disease in a Han Chinese population.
|
19332042 |
2009 |
|
Coronary Arteriosclerosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study demonstrates for the first time that the MCP-1 gene -2578A>G polymorphism is associated with an excess risk of coronary atherosclerosis in an asymptomatic population and demonstrates an apparent interaction with CAD risk factor burden.
|
16934270 |
2007 |
|
Coronary Arteriosclerosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants of the monocyte chemoattractant protein-1 gene and its receptor CCR2 and risk of coronary artery disease: a meta-analysis.
|
21868018 |
2011 |
|
Coronary Arteriosclerosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Currently, there is conflicting evidence regarding an association between polymorphisms in CCR2/MCP-1 and CCR5/RANTES and coronary artery disease.
|
15017357 |
2004 |
|
Coronary Arteriosclerosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association of -2518A>G promoter polymorphism in the monocyte chemoattractant protein-1 (MCP-1) gene with type 2 diabetes and coronary artery disease.
|
23930970 |
2013 |
|
Coronary Arteriosclerosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Lack of association between the -2518G/A polymorphism of the MCP-1 gene and ischaemic heart disease: a family-based investigation.
|
15245376 |
2004 |
|
Coronary Arteriosclerosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Impact of MCP-1 and CCR-2 gene polymorphisms on coronary artery disease susceptibility.
|
22752804 |
2012 |
|
Coronary Arteriosclerosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Monocyte chemoattractant protein-1-2518 G/A polymorphism, plasma levels, and premature stable coronary artery disease.
|
19247801 |
2010 |
|
Diabetic Nephropathy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Most of these eleven genetic variants were involved in GPCR signaling and receptor binding pathways whereas four were involved in chronic kidney failure. rs833061 [OR 2.08 (95% CI 1.63-2.66)] in the VEGFA gene and rs3917887 [OR 2.04 (95% CI 1.64-2.54)] in the CCL2 gene showed the most significant association with the risk of diabetic nephropathy.
|
25280384 |
2014 |
|
Diabetic Nephropathy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, MCP-1 AA genotype and A allele may play a specific role(s) in determining diabetic susceptibility, but do not seem to be important in the clinical manifestations of DN.
|
20960176 |
2010 |
|
Diabetic Nephropathy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We genotyped single nucleotide polymorphism (SNPs) in the MCP-1 G-2518A, CCR2 G46295A, RANTES C-28G and G-403A in 177 diabetic end-stage renal disease (ESRD) patients and 184 patients without renal involvement (controls) in order to investigate the effects of these SNPs on DN in Korean patients with type 2 DM.
|
17728497 |
2007 |
|
Diabetic Nephropathy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated -2518 A/G polymorphism of the MCP-1 gene in type 2 DM patients with progressive kidney failure (n=112) compared with matched type 2 DM patients without nephropathy (diabetic control, n=112) and healthy controls (n=230).
|
17982227 |
2007 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Association of MCP-1 -2518 A/G single nucleotide polymorphism with the serum level of CRP in Slovak patients with ischemic heart disease, angina pectoris, and hypertension.
|
19639050 |
2009 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Three different main disease subgroups of CRF (hypertension, diabetes mellitus, and atherosclerosis) patients were also evaluated, and significant associations were found between hypertension (genotype: χ (2) = 9.28, p = 0.01; allele: χ (2) = 6.00, p = 0.01), atherosclerosis (genotype: χ (2) = 5.37, p = 0.02; allele: χ (2) = 4.13, p = 0.04), and distributions of MCP-1 -2518 A>G genotypes and alleles.
|
25655256 |
2015 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
To better understand hypertension development, the authors determined whether monocyte chemoattractant protein-1 (MCP-1) is associated with arterial stiffness (pulse wave velocity [PWV]) and carotid intima-media wall thickness (cIMT) in a young apparently healthy black and white population (N=403, aged 20-30 years).
|
27453537 |
2017 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The association between the -2518 G/A polymorphism of MCP-1 gene and hypertension remained significant after adjustment for other well-established cardiovascular risk factors.
|
18977211 |
2009 |
|
Kidney Failure, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Therefore, in this study, we aimed to investigate the effect of MCP-1 gene -2518 A>G promoter polymorphism in chronic renal failure (CRF) patients requiring long-term hemodialysis.
|
25655256 |
2015 |
|
Kidney Failure, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
There was no statistically significant difference in the distribution of MCP-1 genotypes between ESRD patients without CVD and healthy controls.
|
19014891 |
2008 |
|
Kidney Failure, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Four polymorphisms showed association with ESRD: rs1801275 in the interleukin 4 receptor (IL4R) gene (OR: 0.66 (95%CI = 0.46-0.95); p = 0.025; overdominant model), rs4586 in chemokine (C-C motif) ligand 2 (CCL2) gene (OR: 0.70 (95%CI = 0.54-0.90); p = 0.005; additive model), rs301640 located in an intergenic binding site for signal transducer and activator of transcription 4 (STAT4) (OR: 1.82 (95%CI = 1.17-2.83); p = 0.006; additive model) and rs7830 in the nitric oxide synthase 3 (NOS3) gene (OR: 1.31 (95%CI = 1.01-1.71); p = 0.043; additive model).
|
22817530 |
2012 |
|
Kidney Failure, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, there were no associations of MCP-1, CCR2 and RANTES promoter SNPs with diabetic ESRD in Korean population.
|
17728497 |
2007 |