|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
RANTES G-401A was not associated with physician-diagnosed asthma (P = 0.408).
|
15715189 |
2005 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Asthma is a complex inherited disease.The study was undertaken to identify the association of RANTES promoter polymorphisms with atopy and asthma using family-based association tests (FBATs) and generation-specific case-control analyses.
|
15592421 |
2005 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Virus-infected subjects with acute asthma or no asthma had increased RANTES (regulated on activation, normal T cell expressed and secreted) and macrophage inflammatory protein-1alpha messenger RNAs compared with other groups.
|
15894599 |
2005 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
The RANTES -403G/A polymorphism did not influence asthma/atopy susceptibility, blood eosinophil count, or bronchial hyperresponsiveness.
|
12789231 |
2003 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
We have evaluated the effects of doses ranging from 10 ng to 100 micro g of two CC chemokine receptor antagonists, Met-RANTES/CC chemokine ligand 5 (CCL5) and aminooxypentane-RANTES/CCL5, in preventing inflammation in the OVA-sensitized murine model of human asthma.
|
14607956 |
2003 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The RANTES -403G/A polymorphism did not influence asthma/atopy susceptibility, blood eosinophil count, or bronchial hyperresponsiveness.
|
12789231 |
2003 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The promoter polymorphisms in the RANTES gene did not have a detectable effect on the susceptibility to asthma or allergy or on the blood eosinophil count.
|
11544456 |
2001 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We have recently identified a polymorphism within the RANTES promoter (-403 G-->A) and have examined its role, using a PCR-RFLP assay, in the development of atopy and asthma in 201 Caucasian subjects.
|
11197694 |
2000 |
|
Asthma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our data indicate that the suppression of the expression of RANTES can be accomplished by TZD treatment, raising the possibility that TZD might be of therapeutic value in diseases such as asthma.
|
10386610 |
1999 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Taken together, these findings suggest that eosinophils play a crucial role in the pathogenesis, particularly in eosinophil and T lymphocyte recruitment into the inflamed sites in asthma through RANTES production.
|
9363922 |
1997 |
|
Asthma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These observations support the view that atopic and nonatopic asthma are associated with combined bronchial mucosal expression of CC chemokines (RANTES and MCP-3), together with eosinophil-active cytokines (IL-5, GM-CSF, and IL-3).
|
8998072 |
1997 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
CTD_human |
RANTES was also expressed in the bronchial epithelium in vivo, as indicated by positive immunocytochemical staining of bronchial biopsy tissues obtained from mild asthmatic patients before and after treatment with 500 micrograms of inhaled beclomethasone dipropionate (BDP) twice daily or matched placebo for 4 mo.
|
8534483 |
1996 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Thus, RANTES is constitutively expressed in the airways and RANTES mRNA is elevated in airways of patients with mild asthma, supporting a role for RANTES in normal and asthmatic airways.
|
8970374 |
1996 |
|
Hyperoxaluria
|
0.500 |
Biomarker
|
disease |
CTD_human |
NF-kappaB and chemokine-cytokine expression in renal tubulointerstitium in experimental hyperoxaluria. Role of the renin-angiotensin system.
|
16284884 |
2005 |
|
Hyperoxaluria
|
0.500 |
Biomarker
|
disease |
RGD |
NF-kappaB and chemokine-cytokine expression in renal tubulointerstitium in experimental hyperoxaluria. Role of the renin-angiotensin system.
|
16284884 |
2005 |
|
Dermatitis, Atopic
|
0.390 |
Biomarker
|
disease |
BEFREE |
The objective of this study was to evaluate the relationships of RANTES and RA and AD using a meta-analysis.
|
25607251 |
2015 |
|
Dermatitis, Atopic
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
We show that miR-146a expression is increased in keratinocytes and chronic lesional skin of patients with AD. miR-146a inhibited the expression of numerous proinflammatory factors, including IFN-γ-inducible and AD-associated genes CCL5, CCL8, and ubiquitin D (UBD) in human primary keratinocytes stimulated with IFN-γ, TNF-α, or IL-1β.
|
24996260 |
2014 |
|
Dermatitis, Atopic
|
0.390 |
Biomarker
|
disease |
CTD_human |
Peroxisome proliferator-activated receptor alpha regulates skin inflammation and humoral response in atopic dermatitis.
|
18249437 |
2008 |
|
Dermatitis, Atopic
|
0.390 |
GeneticVariation
|
disease |
LHGDN |
These results support a role for RANTES promoter polymorphisms in susceptibility to atopic dermatitis.
|
17117952 |
2006 |
|
Dermatitis, Atopic
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
These results support a role for RANTES promoter polymorphisms in susceptibility to atopic dermatitis.
|
17117952 |
2006 |
|
Dermatitis, Atopic
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
G-401A polymorphism in RANTES promoter was associated with near-fatal asthma and atopic dermatitis in children.
|
15715189 |
2005 |
|
Dermatitis, Atopic
|
0.390 |
Biomarker
|
disease |
BEFREE |
After treatment with topical tacrolimus twice daily for 8 weeks, significant decreases were found in serum IL-5 levels, immunoreactive cell counts of eotaxin, IL-5, CCR3 and RANTES in AD skin, and tissue eosinophil counts.
|
15948978 |
2005 |
|
Dermatitis, Atopic
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Our results show that some of the skin lesions of beige rats are morphologically similar to human AD, being characterized by inflammatory cell composition in the acute phase, and increased IgE and RANTES levels.
|
15591815 |
2005 |
|
Dermatitis, Atopic
|
0.390 |
Biomarker
|
disease |
BEFREE |
RANTES and MCP-1 mRNA(+) keratinocytes were detected in the basal layer of lesions of patients with AD and psoriasis.
|
11344355 |
2001 |
|
Dermatitis, Atopic
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Atopic dermatitis is associated with a functional mutation in the promoter of the C-C chemokine RANTES.
|
10640782 |
2000 |