CCL11, C-C motif chemokine ligand 11, 6356

N. diseases: 250; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma 		0.010 AlteredExpression disease BEFREE Like eotaxin, vMIP-II activated and chemoattracted human eosinophils by way of CCR3. vMIP-I and vMIP-II, but not cellular MIP-1alpha or RANTES, were highly angiogenic in the chorioallantoic assay, suggesting a possible pathogenic role in Kaposi's sarcoma. 9323208 1997
CUI: C0037199
Disease: Sinusitis
Sinusitis 		0.010 AlteredExpression disease BEFREE Compared with normal controls, the numbers of cells expressing eotaxin mRNA and protein were significantly increased in both allergic and nonallergic sinusitis (P < 0.001). 9409555 1997
CUI: C1318020
Disease: Stromal keratitis
Stromal keratitis 		0.010 Biomarker disease BEFREE Such mice demonstrate that eotaxin enhances the magnitude of the early (but not late) eosinophil recruitment after antigen challenge in models of asthma and stromal keratitis. 9034156 1997
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.200 Biomarker disease RGD Eotaxin and capping protein in experimental vasculopathy. 9665468 1998
CUI: C0155877
Disease: Allergic asthma
Allergic asthma 		0.030 Biomarker disease BEFREE These results indicate that eotaxin contributes to the early phase of allergen-induced recruitment of activated eosinophils into the airways of patients with allergic asthma and that other factors are implicated in the persistence of eosinophil infiltration. 9822268 1998
CUI: C0018889
Disease: Helminthiasis
Helminthiasis 		0.020 Biomarker disease BEFREE IL-4 induces eotaxin: a possible mechanism of selective eosinophil recruitment in helminth infection and atopy. 9551956 1998
CUI: C0004096
Disease: Asthma
Asthma 		0.700 Biomarker disease BEFREE The results of this study suggest that ASM may contribute to airway inflammation in asthma through the production and release of eotaxin. 10351942 1999
CUI: C0004096
Disease: Asthma
Asthma 		0.700 AlteredExpression disease BEFREE Eotaxin was expressed by bone marrow cells from all 3 groups, but there was no increase in subjects with asthma. 9893192 1999
CUI: C0004096
Disease: Asthma
Asthma 		0.700 AlteredExpression disease BEFREE Although eotaxin and MCP-4 mRNA were widely expressed in the lungs of subjects with asthma, their expression was particularly evident within the bronchial epithelium and inflammatory cells. 10069883 1999
CUI: C0032285
Disease: Pneumonia
Pneumonia 		0.550 Biomarker disease RGD These data suggest that, in the Sephadex model of lung inflammation, eotaxin up-regulation mediates intrapulmonary accumulation of eosinophils and the development of lung injury. 10595930 1999
CUI: C0032285
Disease: Pneumonia
Pneumonia 		0.550 AlteredExpression disease BEFREE There is an increased expression of eotaxin and MCP-4 mRNA within the peripheral airways of lungs of asthmatic subjects, suggesting that these chemokines contribute to the small airways and peripheral lung inflammation in asthma. 10069883 1999
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.350 AlteredExpression disease BEFREE Immunoreactivity and transcripts of eotaxin and CCR3 were significantly increased in lesional skin from atopic dermatitis, but not in nonatopic controls. 10417617 1999
CUI: C3714636
Disease: Pneumonitis
Pneumonitis 		0.350 AlteredExpression disease BEFREE There is an increased expression of eotaxin and MCP-4 mRNA within the peripheral airways of lungs of asthmatic subjects, suggesting that these chemokines contribute to the small airways and peripheral lung inflammation in asthma. 10069883 1999
CUI: C0014457
Disease: Eosinophilia
Eosinophilia 		0.100 AlteredExpression disease BEFREE Levels of eotaxin expression correlated directly with the extent of tissue eosinophilia. 10194423 1999
CUI: C0014457
Disease: Eosinophilia
Eosinophilia 		0.100 AlteredExpression disease BEFREE Airway eosinophilia is a prominent feature of asthma that is believed to be mediated in part through the expression of specific chemokines such as eotaxin, a potent eosinophil chemoattractant that is highly expressed by epithelial cells and inflammatory cells in asthmatic airways. 10351942 1999
CUI: C1306759
Disease: Eosinophilic disorder
Eosinophilic disorder 		0.100 AlteredExpression group BEFREE Airway eosinophilia is a prominent feature of asthma that is believed to be mediated in part through the expression of specific chemokines such as eotaxin, a potent eosinophil chemoattractant that is highly expressed by epithelial cells and inflammatory cells in asthmatic airways. 10351942 1999
CUI: C1306759
Disease: Eosinophilic disorder
Eosinophilic disorder 		0.100 AlteredExpression group BEFREE Levels of eotaxin expression correlated directly with the extent of tissue eosinophilia. 10194423 1999
CUI: C0013595
Disease: Eczema
Eczema 		0.050 AlteredExpression disease BEFREE Immunoreactivity and transcripts of eotaxin and CCR3 were significantly increased in lesional skin from atopic dermatitis, but not in nonatopic controls. 10417617 1999
CUI: C0019829
Disease: Hodgkin Disease
Hodgkin Disease 		0.040 AlteredExpression disease BEFREE Within HD subtypes, expression of IP-10 and Mig was highest in the mixed cellularity (MC) subtype, whereas expression of eotaxin and MDC was highest in the nodular sclerosis (NS) subtype. 10194423 1999
CUI: C0019829
Disease: Hodgkin Disease
Hodgkin Disease 		0.040 Biomarker disease BEFREE Our data suggest that eotaxin is involved in the pathobiology of Hodgkin's disease by contributing to eosinophil and T-lymphocyte recruitment. 10477736 1999
CUI: C0011603
Disease: Dermatitis
Dermatitis 		0.020 AlteredExpression disease BEFREE Eotaxin expression in Onchocerca volvulus-induced dermatitis after topical application of diethylcarbamazine. 10479181 1999
CUI: C0018889
Disease: Helminthiasis
Helminthiasis 		0.020 Biomarker disease BEFREE An eotaxin is a chemoattractant specific for eosinophils that are known to play a role in helminth infection and allergic responses. 10460747 1999
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.010 GeneticVariation disease BEFREE Reactivity of eosinophils to the monoclonal antibody against CCR3 and the chemotaxis to eotaxin were slightly reduced in this patient as compared with healthy controls or a patient with Behçet disease homozygous for the common allele, while CCR3 mRNA level was not different. 11196669 1999
CUI: C0037274
Disease: Dermatologic disorders
Dermatologic disorders 		0.010 Biomarker group BEFREE Together, these observations are consistent with a role for eotaxin in recruitment of eosinophils to the dermis in early stage onchocercal skin disease. 10479181 1999
CUI: C0042961
Disease: Intestinal Volvulus
Intestinal Volvulus 		0.010 AlteredExpression disease BEFREE Eotaxin expression in Onchocerca volvulus-induced dermatitis after topical application of diethylcarbamazine. 10479181 1999