|
Alzheimer's Disease
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Patients with AD had higher levels of proinflammatory and anti-inflammatory cytokines (eotaxin, interleukin [IL]-1ra, IL-4, IL-7, IL-8, IL-9, IL-10, IL-15, granulocyte colony-stimulating factor, monocyte chemotactic protein 1, platelet-derived growth factor, tumor necrosis factor alfa) compared to nondemented controls.
|
30711675 |
2019 |
|
Alzheimer's Disease
|
0.090 |
Biomarker
|
disease |
BEFREE |
Thus, the age-related increase in CCL11 may be a risk factor of AD, and antagonizing CCR3 may bring therapeutic benefits to AD.
|
27878757 |
2017 |
|
Alzheimer's Disease
|
0.090 |
Biomarker
|
disease |
BEFREE |
Logistic regression identified five (FB, FH, sCR1, MCP-1, eotaxin-1) that, age/APOε4 adjusted, optimally differentiated AD and CTL (AUC: 0.79), and three (sCR1, MCP-1, eotaxin-1) that optimally differentiated AD and MCI (AUC: 0.74).
|
31047856 |
2019 |
|
Alzheimer's Disease
|
0.090 |
Biomarker
|
disease |
BEFREE |
Altogether, these results suggest eotaxin-1 as a novel modifier of Alzheimer's disease AAO and open potential avenues for therapy.
|
26324103 |
2015 |
|
Alzheimer's Disease
|
0.090 |
Biomarker
|
disease |
BEFREE |
Finally, a receiver operating characteristic (ROC) curve analysis demonstrated CSF CCL11 accurately distinguished CTE subjects from non-athlete controls and AD subjects (AUC = 0.839, 95% CI 0.62-1.058, p = 0.028).
|
28950005 |
2017 |
|
Alzheimer's Disease
|
0.090 |
Biomarker
|
disease |
BEFREE |
Circulating levels of the pro-inflammatory cytokine C-C motif chemokine 11 (CCL11, also known as eotaxin-1) are increased in several animal models of neuroinflammation, including traumatic brain injury and Alzheimer's disease.
|
28634890 |
2017 |
|
Alzheimer's Disease
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
In humans, elevated plasma levels of CCL11 have been observed in Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, and secondary progressive multiple sclerosis when compared to age-matched, healthy controls.
|
27664933 |
2018 |
|
Alzheimer's Disease
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The association of a protective haplotype with a 10-year delay in the onset of Alzheimer's disease and the identification of a CCL11 variant with possible functional roles in this association might allow the future development of immunomodulators with the potential to halve disease incidence.
|
26482651 |
2015 |
|
Alzheimer's Disease
|
0.090 |
Biomarker
|
disease |
BEFREE |
A correlation has been reported between inflammatory C-C motif chemokine ligand 11 (CCL11, or eotaxin-1) and neurodegeneration in Alzheimer's disease.
|
29222992 |
2018 |
|
Amyotrophy, monomelic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Eotaxin, MCP-1 and RANTES levels were significantly higher in Hirayama disease (N=11) than in normal controls (N=12).
|
27956076 |
2017 |
|
Ankylosing spondylitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that the serum level of CCL11 was associated with structural damage in patients with AS, suggesting that CCL11 may serve as a promising biomarker for new bone formation in AS.
|
29850965 |
2018 |
|
Anxiety
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, patients with mood disorders (<i>N</i> = 42) and/or anxiety (<i>N</i> = 16) had lower CCL11 concentrations than non-comorbid patients being more evident in women.
|
28149283 |
2016 |
|
Anxiety Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Thus, patients with mood disorders (<i>N</i> = 42) and/or anxiety (<i>N</i> = 16) had lower CCL11 concentrations than non-comorbid patients being more evident in women.
|
28149283 |
2016 |
|
Aortic Aneurysm, Abdominal
|
0.010 |
Biomarker
|
disease |
BEFREE |
Contrary to reports suggesting a distinct T helper 2-associated inflammatory profile in AAA, this current study suggests a more-generalized pattern of inflammation, albeit with some potentially distinct features, including elevated plasma eotaxin and decreased plasma RANTES.
|
27126477 |
2016 |
|
Aortic Valve Insufficiency
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to assess the impact of a single nasal allergen challenge (NAC) on levels of eotaxin and IL-8 and the inflammatory cells in upper and lower airways of allergic rhinitis (AR) patients.
|
21703102 |
2011 |
|
Arteriosclerosis
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
SDF and eotaxin, as regulators of proMMP-2 expression and by engaging in receptor cross-talk, may play critical roles in atherosclerosis, restenosis, and plaque rupture.
|
16343467 |
2006 |
|
Arteriosclerosis
|
0.050 |
Biomarker
|
disease |
BEFREE |
CCL11 (Eotaxin-1) is an important inflammatory cytokine belonging to the CC family of chemokines associated with a number of infection or inflammation-related diseases such as atherosclerosis and stroke.
|
25237944 |
2014 |
|
Arteriosclerosis
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of eotaxin and the CCR3 receptor in human atherosclerosis: using genomic technology to identify a potential novel pathway of vascular inflammation.
|
11056090 |
2000 |
|
Arteriosclerosis
|
0.050 |
Biomarker
|
disease |
BEFREE |
If confirmed in other cohorts, these data support the emerging hypothesis that eotaxin participates in atherosclerosis.
|
15186951 |
2004 |
|
Arteriosclerosis
|
0.050 |
Biomarker
|
disease |
BEFREE |
BACKGROUND CCL11 is an important inflammatory cytokine associated with inflammation-related diseases such as atherosclerosis and stroke.
|
28873081 |
2017 |
|
aspirin intolerance
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
But the protein synthesis of eotaxin- and eotaxin-2-mRNA was significantly (P < 0.05) higher in TRIAD (3.3 pg/mg and 3.4 ng/mg tissue weight) (4 ng/mg tissue weight), than in NP, ATA, or AINA (1.8 pg/mg and 2.1 ng/mg, 2.1 pg/mg and 1.6 ng/mg, or 1.7 pg/mg and 2.2 ng/mg tissue weight, respectively).
|
14616128 |
2003 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We studied the correlation between the eotaxin gene expression level in the material from nasal brushing and respiratory tests in asthma and COPD patients.
|
22846146 |
2012 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The eotaxin receptor CCR3 was expressed at high levels on submucosal endothelial cells in patients and a murine model of asthma.
|
26810221 |
2016 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Budesonide inhibited airway hyperreactivity, eosinophil counts in the lung and bronchoalveolar lavage (BAL) and CCL11, IL-13, and IL-23p19 release in the BAL of mice sensitized and challenged with <i>Af</i> (<i>p</i> < 0.05).
|
31572383 |
2019 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
CCR3 is the cognate receptor for major human eosinophil chemoattractants from the eotaxin family of proteins that are elevated in asthma and correlate with disease severity.
|
29423947 |
2018 |