|
Gallbladder adenocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of MRP isoforms was studied in vitro in Mz-ChA-1 cells derived from gallbladder adenocarcinoma by reverse transcription-polymerase chain reaction (RT-PCR), immunoblotting and immunofluorescence microscopy.
|
18226047 |
2008 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The properties of glioblastoma and astrocytoma stem-like cells on anti-apoptotic and MRP genes are: anti-apoptotic gene livin and survivin are elevated in CSCs but are the most increased in just differentiated CSCs; MRP1 gene is significantly increased and MRP3 is decreased in CSCs, but when differentiating the MRP3 gene starts a remarkable increase in CSCs; the expression of anti-apoptotic and MRP genes shows no differences between the CSCs isolated from glioblastoma and astrocytoma tissues.
|
18462887 |
2008 |
|
Biliary Tract Cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To further define the role of MRP family members in biliary tract cancer, we studied the expression and localization of MRP2 and MRP3 in cholangiocellular carcinomas and gallbladder carcinomas.
|
18226047 |
2008 |
|
Childhood Astrocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The properties of glioblastoma and astrocytoma stem-like cells on anti-apoptotic and MRP genes are: anti-apoptotic gene livin and survivin are elevated in CSCs but are the most increased in just differentiated CSCs; MRP1 gene is significantly increased and MRP3 is decreased in CSCs, but when differentiating the MRP3 gene starts a remarkable increase in CSCs; the expression of anti-apoptotic and MRP genes shows no differences between the CSCs isolated from glioblastoma and astrocytoma tissues.
|
18462887 |
2008 |
|
Bone Diseases, Developmental
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In vitro testing of RNase MRP multiprotein-specific mRNA and rRNA cleavage of different mutations revealed a strong correlation between the decrease in rRNA cleavage in ribosomal assembly and the degree of bone dysplasia, whereas reduced mRNA cleavage, and thus cell-cycle impairment, predicts the presence of hair hypoplasia, immunodeficiency, and hematological abnormalities and thus increased cancer risk.
|
17701897 |
2007 |
|
Cystic Fibrosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Besides its antiinflammatory and antimicrobial activities, one possibility could be the overexpression induction of the multidrug resistance-associated protein (MRP), which could affect chloride transport, thus overcoming the ion transport defect of cystic fibrosis.
|
16167518 |
2005 |
|
Leigh Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Several of the MRP genes map to loci associated with disorders consistent with impaired oxidative phosphorylation, such as Leigh Syndrome, multiple mitochondrial dysfunctions, and non-syndromic hearing loss.
|
15908146 |
2005 |
|
Lichen Planus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Correspondingly, upregulation of MRP expression was found in lesional skin taken from patients with psoriasis and lichen planus.
|
15654950 |
2005 |
|
Psoriasis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Correspondingly, upregulation of MRP expression was found in lesional skin taken from patients with psoriasis and lichen planus.
|
15654950 |
2005 |
|
Pancreatic carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, we determined the localization of the 4 MRP proteins in normal human pancreas and in pancreatic carcinoma.
|
15688370 |
2005 |
|
Mitochondrial Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Nuclear MRP genes and mitochondrial disease.
|
15908146 |
2005 |
|
Hodgkin Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression of MDR1 and MRP genes in patients with low-grade and high-grade non-Hodgkin's lymphomas with primary bone marrow involvement before and after chemotherapy was investigated.
|
15560070 |
2004 |
|
Rhabdomyosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that MRP expression could be a prognostic factor in patients with rhabdomyosarcoma.
|
14654923 |
2004 |
|
Childhood Rhabdomyosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that MRP expression could be a prognostic factor in patients with rhabdomyosarcoma.
|
14654923 |
2004 |
|
Adult Liver Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
No appreciable correlation was found between liver cancer 99mTc-MIBI images and expression of MRP or LRP on the level of protein or mRNA.
|
15112342 |
2004 |
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
No appreciable correlation was found between liver cancer 99mTc-MIBI images and expression of MRP or LRP on the level of protein or mRNA.
|
15112342 |
2004 |
|
Adult Rhabdomyosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that MRP expression could be a prognostic factor in patients with rhabdomyosarcoma.
|
14654923 |
2004 |
|
Malignant neoplasm of liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
No appreciable correlation was found between liver cancer 99mTc-MIBI images and expression of MRP or LRP on the level of protein or mRNA.
|
15112342 |
2004 |
|
Primary biliary cirrhosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study aimed to determine the expression of hepatobiliary transport systems for bile salts (Na(+)/taurocholate cotransporter, NTCP; bile salt export pump, BSEP), organic anions (organic anion transporting protein, OATP2; canalicular conjugate export pump, MRP2; basolateral MRP homologue, MRP3), organic cations (canalicular multidrug export pump, MDR1), and phospholipids (canalicular phospholipid flippase MDR3) in livers from patients with advanced stages of PBC.
|
12763363 |
2003 |
|
Metaphyseal chondrodysplasia Schmid type
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We performed a study on the genes coding for the RNA components of RNase MRP (MRPR) and RNase P (H1RNA) among 20 patients with diagnosis of MCDS and no mutations in COL10A1.
|
14569119 |
2003 |
|
Adenoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
According to the results of IHA, the 33 parathyroid adenomas were separated into four groups: (1) 2 adenomas with both positive Pgp and positive MRP expression, (2) 1 adenomas with positive Pgp but negative MRP expression, (3) 2 adenomas with negative Pgp but positive MRP expression, and (4) 28 adenomas with both negative Pgp and negative MRP expression.
|
11929704 |
2002 |
|
Contracture
|
0.010 |
Biomarker
|
disease |
BEFREE |
Muscle activity recorded from human and rabbit detrusor showed that f-MLP caused contracture of the detrusor, which was completely blocked by indomethacin and partially blocked by individual cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors.
|
11992095 |
2002 |
|
Parathyroid Adenoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Not only the size of parathyroid adenomas, but also significant Pgp or MRP expression limited the sensitivity of Tc-TF parathyroid imaging to localize parathyroid adenomas before operation.
|
11929704 |
2002 |
|
Azoospermia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To provide better insight into the relationship among the expression behavior in vivo of the three genes in human testis, analysis of MDR1 and MRP gene expression in testicular biopsies was performed and related to the presence of CFTR gene mutations in congenital absence of the vas deferens (CAVD: n = 20) and non-CAVD (n = 30) infertile patients with azoospermia or severe oligozoospermia.
|
11466205 |
2001 |
|
Genital Neoplasms, Female
|
0.010 |
Biomarker
|
group |
BEFREE |
We studied the expression of topoisomerase II alpha(Topo II alpha) and multidrug resistance-associated protein (MRP), and then correlated them with the in vitro chemosensitivities of gynecologic tumor cells using immunohistochemistry and a tetrazolium dye (MTT) assay.
|
11712788 |
2001 |