|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The serotonin transporter (5-HTT) is a candidate gene for bipolar disorder (BPD).
|
15824745 |
2005 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The overall odds ratio (OR) for the combined individual results was significant for BD and the two 5-HTT polymorphisms: Mantel-Haenszel weighted OR=1.14, CI: 1.03-1.26, P=0.015 for the promoter locus (N=3467) and Mantel-Haenszel Weighted odds ratio OR=1.18, CI: 1.05-1.32, P=0.004 for the VNTR locus (N=3620).
|
12851635 |
2003 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The human serotonin transporter gene (5-HTT) is a candidate for the pathogenesis of mood disorders, including bipolar disorder (BPD).
|
16186633 |
2005 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Detailed analysis of the serotonin transporter gene (SLC6A4) shows no association with bipolar disorder in the Northern Swedish population.
|
18792946 |
2009 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
By affected-sib-pair analysis and the transmission/disequilibrium test, we found no significant linkage or association of 5-HTT to bipolar disorder.
|
9514585 |
1998 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
5-HTTLPR modulated the relationship between early life stress and the core features of bipolar illness.
|
25219494 |
2014 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that this new polymorphism in the 5-HTT gene may not influence suicidal behaviour in patients with bipolar disorder.
|
15986189 |
2005 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The effects of 5-HTTLPR on the anomalous emotional processing in BD might be mediated by changes of WM microstructure in key WM tracts contributing to the functional integrity of the brain.
|
25704032 |
2015 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We have analyzed 86 unrelated patients (47 with bipolar disorder and 39 with schizophrenia) and 98 normal controls from the Brazilian population for the 5-HTTLPR.
|
9603609 |
1998 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We performed a case-control study to compare 5-HTTLPR genotype and allelic frequencies between 43 patients with a DSM-IV diagnosis of BD, with at least one manic/hypomanic episode associated with treatment with proserotonergic antidepressants (AAM+) and 69 unrelated, matched bipolar patients, who had been exposed to proserotonergic antidepressants without development of manic symptoms (AAM-(*)).
|
18534687 |
2009 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
CTD_human |
The 5-HTTLPR polymorphism could be a useful contributor, among other clinical variables, to predict the risk for manic switches when a patient with bipolar disorder is treated with antidepressant drugs.
|
16395126 |
2006 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Meta-analyses suggest small positive associations between the polymorphism in the serotonin transporter promoter region (5-HTTLPR) and bipolar disorder, suicidal behavior, and depression-related personality traits but not yet to MDD itself.
|
16300747 |
2006 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Nevertheless, the findings might suggest that alterations in the structure of 5-HTT are involved in the pathogenesis of bipolar disorder, which could have major implications in treatment.
|
11093065 |
2000 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, the 5-HTTLPR was estimated in 67 patients with bipolar mood disorder, receiving lithium carbonate for prophylactic purposes for the period of more than 5 years (mean 15 years).
|
15849387 |
2005 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
However, we found that CpG sites of SLC6A4, which were hypermethylated in patients with bipolar disorder, were hypomethylated in the neuroblastoma cells treated with mood stabilizers.
|
23931339 |
2013 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Lack of linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and bipolar disorder.
|
10898918 |
2000 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the genetic variability of the 5-HTT gene is not a major risk factor for manic depression.
|
9611675 |
1998 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
To further investigate whether reduced 5-HTT function could be an endophenotype in manic depressive illness, we looked for abnormalities of platelet 5-HTT among subjects who are potential carriers of genetic vulnerability to manic depressive illness (MDI).
|
10624553 |
1999 |
|
Bipolar Disorder
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
This is the first study to report the role of epigenetic modification of SLC6A4 in BD using an unbiased approach, which provides an insight for its pathophysiology.
|
22832526 |
2011 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We studied a functional polymorphism of the serotonin transporter (5-HTT) gene (a 44 bp insertion/deletion in the 5-HTT-linked polymorphic region (5-HTTLPR)) and lifetime history of antidepressant-induced mania (AIM) in a population of 305 patients with bipolar affective disorder.
|
12746735 |
2003 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Polymorphisms within the DRD1, DRD2, DRD3, DAT1, 5-HTTLPR and HTR2A genes are being studied for association with lithium prophylaxis in a sample of 155 Sardinian unrelated probands affected by bipolar disorder (BP).
|
19647327 |
2009 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Only antianxiety medication naïve offspring of BD parents were found to have an association between 5-HTTLPR genotypes and anxiety symptoms.
|
26218602 |
2015 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
LHGDN |
The serotonin transporter (5-HTT) is a candidate gene for bipolar disorder (BPD).
|
15824745 |
2005 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The 5-HTTLPR polymorphism in the serotonin transporter gene (SLC6A4) may contribute to the risk of bipolar disorder, suicidal behavior, and neuroticism, but association to the lifetime risk of major depression has not been shown.
|
15802092 |
2005 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Is the 5-HTTLPR polymorphism associated with bipolar disorder or with suicidal behavior of bipolar disorder patients?
|
17579356 |
2008 |