|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The results provide preliminary evidence that alterations in the primary structure of 5-HTT are not generally involved in the pathogenesis of unipolar depression and manic-depressive illness.
|
7711157 |
1995 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association studies of bipolar disorder at the human serotonin transporter gene (hSERT; 5HTT).
|
9322234 |
1997 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We selected 42 patients with bipolar disorder type I (BPI) and 40 healthy controls for genetic analysis of DNA polymorphisms in the serotonin receptor 2c (5-HTR2c) and serotonin transporter (5-HTT) genes.
|
9342201 |
1997 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
By affected-sib-pair analysis and the transmission/disequilibrium test, we found no significant linkage or association of 5-HTT to bipolar disorder.
|
9514585 |
1998 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The present study analysed this variation and another variation in the SERT gene and nearby DNA markers in order to test for linkage between SERT and bipolar affective disorder in two Danish families.
|
9543202 |
1998 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We have analyzed 86 unrelated patients (47 with bipolar disorder and 39 with schizophrenia) and 98 normal controls from the Brazilian population for the 5-HTTLPR.
|
9603609 |
1998 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the genetic variability of the 5-HTT gene is not a major risk factor for manic depression.
|
9611675 |
1998 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Allelic association case-control analysis of a deletion/insertion polymorphism in the serotonin transporter-linked polymorphic region (5-HTTLPR) has suggested associations with unipolar disorder, bipolar disorder, depression, and Alzheimer's disease.
|
9848084 |
1998 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A functional polymorphism in the upstream regulatory region of the serotonin transporter gene (5-HTTLPR) has been recently reported to be associated with both unipolar and bipolar disorder.
|
10395220 |
1999 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our results do not support the hypothesis of a role for DRD2, DRD4, DAT, or SERT in bipolar disorder.
|
10490710 |
1999 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
To further investigate whether reduced 5-HTT function could be an endophenotype in manic depressive illness, we looked for abnormalities of platelet 5-HTT among subjects who are potential carriers of genetic vulnerability to manic depressive illness (MDI).
|
10624553 |
1999 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Although it will be important to extend the present study in a larger sample, our initial results do not suggest any large association with alleles of the VNTR in the SERT gene and bipolar disorder in Indian patients.Am.J. Med.Genet.(Neuropsychiatr.Genet.)96:170-172, 2000.
|
10893491 |
2000 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Lack of linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and bipolar disorder.
|
10898918 |
2000 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
An association study of bipolar mood disorder (type I) with the 5-HTTLPR serotonin transporter polymorphism in a human population isolate from Colombia.
|
11018311 |
2000 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Nevertheless, the findings might suggest that alterations in the structure of 5-HTT are involved in the pathogenesis of bipolar disorder, which could have major implications in treatment.
|
11093065 |
2000 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the role of the SLC6A4 variants in the pathogenesis of antidepressant-induced mania in BP.
|
11386982 |
2001 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
CTD_human |
Relative to the comparison subjects, subjects with bipolar disorder without panic disorder, but not those with comorbid bipolar disorder and panic disorder, showed significantly higher frequencies of the COMT Met158 and the short 5-HTTLPR alleles and genotypes.
|
11772685 |
2002 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The findings support the hypothesis that comorbid panic disorder identifies a genetic subtype of bipolar disorder and suggest a role for COMT and 5-HTT in vulnerability to these disorders.
|
11772685 |
2002 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Differential sampling procedures may influence the proportion of AAO subgroups in a given association study, and therefore these results may explain the conflicting results obtained in studies of the association between the SLC6A4 gene polymorphism and bipolar affective disorder (BPAD).
|
12431765 |
2002 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We studied a functional polymorphism of the serotonin transporter (5-HTT) gene (a 44 bp insertion/deletion in the 5-HTT-linked polymorphic region (5-HTTLPR)) and lifetime history of antidepressant-induced mania (AIM) in a population of 305 patients with bipolar affective disorder.
|
12746735 |
2003 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The overall odds ratio (OR) for the combined individual results was significant for BD and the two 5-HTT polymorphisms: Mantel-Haenszel weighted OR=1.14, CI: 1.03-1.26, P=0.015 for the promoter locus (N=3467) and Mantel-Haenszel Weighted odds ratio OR=1.18, CI: 1.05-1.32, P=0.004 for the VNTR locus (N=3620).
|
12851635 |
2003 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Further evidence for a possible association between serotonin transporter gene and lithium prophylaxis in mood disorders.
|
15111989 |
2004 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Current studies have found associations of SLC6A4 polymorphisms with several psychiatric traits including bipolar affective disorder (BPD) in various populations; however, studies with contradictory results were also reported.
|
15167705 |
2004 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The 5-HTTLPR polymorphism in the serotonin transporter gene (SLC6A4) may contribute to the risk of bipolar disorder, suicidal behavior, and neuroticism, but association to the lifetime risk of major depression has not been shown.
|
15802092 |
2005 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The serotonin transporter (5-HTT) is a candidate gene for bipolar disorder (BPD).
|
15824745 |
2005 |