|
Acute monocytic leukemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML.
|
19805619 |
2009 |
|
Acute mountain sickness
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We explore the role of the predicted decrease in plasma OPN levels in humans upon high-altitude exposure and its relationship with acute mountain sickness (AMS), as well as superoxide dismutase (SOD) and malondialdehyde (MDA).
|
30165389 |
2018 |
|
Acute myocarditis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we show that high expression levels of OPN in acute myocarditis are associated with consecutive development of extensive fibrosis that can be reduced by treatment with a vitamin D analog.
|
19246678 |
2009 |
|
Acute-On-Chronic Liver Failure
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Further ELISA analysis confirmed the significant up-regulation of GP73, MMR, OPN and down-regulation of ATIII, HPX, APO-CII in HBV-ACLF plasma samples (<i>p</i> < 0.01).
|
29270132 |
2017 |
|
Adenocarcinoma
|
0.370 |
AlteredExpression
|
group |
LHGDN |
Frequent OPN expression is typical of, but not specific for MM, whereas it appears to select adenocarcinoma cases with p65 and MMP-9 expression, suggesting a link with EGFR signalling pathways.
|
17493236 |
2007 |
|
Adenocarcinoma
|
0.370 |
Biomarker
|
group |
BEFREE |
Evaluation of murine MPE-competent lung and colon adenocarcinomas revealed that these tumors actively attract and subsequently degranulate MCs in the pleural space by elaborating CCL2 and osteopontin.
|
25915587 |
2015 |
|
Adenocarcinoma
|
0.370 |
AlteredExpression
|
group |
BEFREE |
Interestingly, Ras-p21 was specifically co-expressed with OPN staining in eight of eight cases with SCC (100%), whereas it was demonstrated in three of ten cases (30%) with AD and only one of 18 cases (5%) with SCLC.
|
11520606 |
2001 |
|
Adenocarcinoma
|
0.370 |
Biomarker
|
group |
CTD_human |
Varied pathways of stage IA lung adenocarcinomas discovered by integrated gene expression analysis.
|
21552421 |
2011 |
|
Adenocarcinoma
|
0.370 |
Biomarker
|
group |
BEFREE |
Patterns of immunoreactivity for osteopontin protein also varied between squamous-cell carcinomas (tumor cell staining) and adenocarcinomas (predominantly tumor-infiltrating macrophages).
|
9311587 |
1997 |
|
Adenocarcinoma
|
0.370 |
Biomarker
|
group |
CTD_human |
Osteopontin but not osteonectin favors the metastatic growth of pancreatic cancer cell lines.
|
20495387 |
2010 |
|
Adenocarcinoma
|
0.370 |
AlteredExpression
|
group |
BEFREE |
One of these genes, osteopontin, was expressed 27-fold higher levels in ampullary adenocarcinomas compared to normal duodenum by genechip analysis.
|
15136764 |
2004 |
|
Adenocarcinoma
|
0.370 |
AlteredExpression
|
group |
BEFREE |
OPN expression was investigated immunohistochemically in 104 adenocarcinomas and 38 MM and correlated with histological features, including tumour type, grade and proliferation and with expression of activated intermediary EGFR signalling pathway molecules p65, p-AKT, p-ERK, p-STAT-3, and of metalloproteinase (MMP)-1, MMP-2 and MMP-9.
|
17493236 |
2007 |
|
Adenocarcinoma
|
0.370 |
Biomarker
|
group |
BEFREE |
Over time, osteopontin expressing dysplastic cells seemed to increase in number in high-grade PIN and increased further in adenocarcinoma, and in metastasis, almost all of the cancer cells immunohistochemically stained positive for osteopontin overexpression.
|
16424021 |
2006 |
|
Adenocarcinoma
|
0.370 |
GeneticVariation
|
group |
BEFREE |
Genetic deletion of osteopontin in TRAMP mice skews prostate carcinogenesis from adenocarcinoma to aggressive human-like neuroendocrine cancers.
|
26700622 |
2016 |
|
Adenocarcinoma Of Esophagus
|
0.020 |
Biomarker
|
disease |
BEFREE |
Osteopontin (OPN/SPP1) isoforms collectively enhance tumor cell invasion and dissemination in esophageal adenocarcinoma.
|
26068949 |
2015 |
|
Adenocarcinoma Of Esophagus
|
0.020 |
Biomarker
|
disease |
BEFREE |
Increased expression of multiple genes in the MET pathway associated with invasive growth, for example, many MMPs and osteopontin, also was found in EAs.
|
16186806 |
2006 |
|
Adenocarcinoma of lung (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, we investigated the involvement of glycogen synthase kinase-3β (GSK-3β) and osteopontin (OPN) in the p90RSK-induced lung adenocarcinoma progression. p90RSK, OPN, and GSK-3β protein expressions were examined in the A549 human lung adenocarcinoma cell line in the presence and absence of BI-D1870 (BID), a p90RSK inhibitor.
|
27236820 |
2016 |
|
Adenocarcinoma of lung (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
SPP1 expression in TAMs isolated from lung adenocarcinoma tissues and PMA-treated THP-1 cells were measured.
|
28830685 |
2017 |
|
Adenocarcinoma of lung (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings indicated that ADH1C and SPP1 might be novel promising biomarkers for predicting LUAD prognosis.
|
31074035 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest that SPP1 and AGER are risk factors for LUAD, and these two genes may be utilized in the prognostic evaluation of patients with LUAD.
|
29849788 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our study of SPP1 upstream invasive network may be useful to identify novel and potentially targets for prognosis and therapy of lung adenocarcinoma.
|
19949890 |
2010 |
|
Adenocarcinoma of lung (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical staining in 20 paired LAC and adjacent normal tissues showed that IGKC, AAT, SH3BGRL3, osteopontin and gelsolin levels were higher in LAC tissues than in adjacent tissuesand were closely associated with LAC.
|
28404947 |
2017 |
|
Adenocarcinoma of lung (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
In response to two different smoke carcinogens, Spp1-deficient mice developed fewer and smaller lung adenocarcinoma with decreased cellular survival and angiogenesis.
|
31740923 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Real time PCR was used to measure expression of VIPR1 and SPP1 mRNA and possible losses or gains of genes in 32 AD.
|
20014941 |
2010 |
|
Adenocarcinoma of lung (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Previously, we and others have shown that bone extracellular matrix proteins such as bone sialoprotein (BSP) and osteopontin (OPN) are expressed in various types of cancer that are characterized by a high affinity for bone including breast, prostate, and lung adenocarcinoma.
|
12929940 |
2003 |