|
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition, OPN is associated with renal stones, but whether it acts as a promoter or inhibitor of stone formation is controversial.
|
11703581 |
2001 |
|
Kidney Calculi
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Metformin prevents nephrolithiasis formation by inhibiting the expression of OPN and MCP-1 in vitro and in vivo.
|
30720053 |
2019 |
|
Kidney Calculi
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The purpose of this study is to evaluate the correlation between urinary OPN level and kidney stone formation and effect of nutrition on OPN level in nephrolithiasis.
|
30114399 |
2018 |
|
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here, we investigated the effects of different phosphorylated states of a synthesized peptide of OPN (the ASARM peptide; acidic, serine- and aspartate-rich motif) on calcium oxalate dihydrate (COD) crystals, a major mineral phase of kidney stones.
|
30016645 |
2018 |
|
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
Based on these data, it is proposed that during urolithiasis, secretion of osteopontin (uropontin) and osteocalcin (or osteocalcin-related gene/protein), and the subsequent incorporation of these proteins into kidney stone matrix, may influence the nucleation, growth processes, aggregation, and/or tubular adhesion of renal calculi in mammalian kidneys.
|
8619372 |
1995 |
|
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
We previously reported the potential therapeutic role of osteopontin (OPN) and macrophages in CaOx kidney stone formation, discovered using genome-recombined mice and genome-wide analyses.
|
27297950 |
2017 |
|
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
The Effects of Melatonin on Ethylene Glycol-induced Nephrolithiasis: Role on Osteopontin mRNA Gene Expression.
|
27717860 |
2017 |
|
Kidney Calculi
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
SPP1 polymorphisms were found to be associated with nephrolithiasis and it may be suggested that SPP1 gene polymorphism could be a useful marker for evaluation of the early genetic risk factor in childhood nephrolithiasis.
|
23235966 |
2012 |
|
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
Calcium oxalate dihydrate (COD) mineral and the urinary protein osteopontin/uropontin (OPN) are commonly found in kidney stones.
|
19581305 |
2009 |
|
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here, we quantitatively investigate the role of phosphorylation in interactions with calcium oxalate monohydrate crystals (COM), using synthetic peptides corresponding to the sequence 220-235 in osteopontin, a major inhibitor of kidney stone-related COM formation.
|
30569197 |
2019 |
|
Malignant Glioma
|
0.560 |
Biomarker
|
disease |
BEFREE |
Elucidation of regulatory mechanisms for OPN induction in glioma cells should facilitate rational design of novel therapeutics for human malignant gliomas.
|
9615723 |
1998 |
|
Malignant Glioma
|
0.560 |
Biomarker
|
disease |
BEFREE |
The literature review suggests that OPN may play important roles in the development and progression of selected cancers of children and young adults, including acute lymphoblastic leukemia, malignant gliomas, AT/RT and Langerhans cell histiocytosis.
|
28326824 |
2017 |
|
Malignant Glioma
|
0.560 |
Biomarker
|
disease |
BEFREE |
Association of Notch-1, osteopontin and stem-like cells in ENU-glioma malignant process.
|
30140373 |
2018 |
|
Malignant Glioma
|
0.560 |
AlteredExpression
|
disease |
BEFREE |
Osteopontin and splice variant expression level in human malignant glioma: radiobiologic effects and prognosis after radiotherapy.
|
23891093 |
2013 |
|
Malignant Glioma
|
0.560 |
AlteredExpression
|
disease |
BEFREE |
Our findings show re-activation of the embryonic-type transcriptional regulation of SPP1 in malignant gliomas and point to the importance of SPP1-CD44 interactions in self-renewal and pluripotency glioma initiating cells.
|
28030801 |
2017 |
|
Malignant Glioma
|
0.560 |
AlteredExpression
|
disease |
BEFREE |
Five potential markers (CD44 antigen (CD44), growth arrest and DNA-damage-inducible, alpha (GADD45A), fibronectin 1 (FN1), CD63 antigen (CD63) and secreted phosphoprotein 1 (SPP1)) showed expression patterns that correlated significantly with malignant glioma.
|
20150644 |
2010 |
|
Lupus Erythematosus, Systemic
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Glomerular expression of osteopontin in biopsies of human crescentic glomerulonephritis (N = 25), IgA nephropathy with crescents (N = 2), and diffuse proliferative lupus glomerulonephropathy with crescents (N = 1) was studied by immunohistochemistry, in situ hybridization, and combined immunohistochemistry/in situ hybridization.
|
10620192 |
2000 |
|
Lupus Erythematosus, Systemic
|
0.500 |
Biomarker
|
disease |
BEFREE |
It has been said that macrophage metalloelastase is related to ulcer formation of the intestine, whereas osteopontin plays an important role in the pathogenesis of systemic lupus erythematosus and rheumatoid arthritis.
|
12842452 |
2003 |
|
Lupus Erythematosus, Systemic
|
0.500 |
Biomarker
|
disease |
BEFREE |
OPN production has been associated with several pathological conditions, including autoimmune diseases (e.g. lupus, multiple sclerosis and rheumatoid arthritis) and cancer.
|
31126876 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A silent polymorphism (707C>T, rs1126616) of osteopontin was significantly associated with SLE.
|
11933203 |
2002 |
|
Lupus Erythematosus, Systemic
|
0.500 |
Biomarker
|
disease |
BEFREE |
Osteopontin and systemic lupus erythematosus association: a probable gene-gender interaction.
|
18335026 |
2008 |
|
Lupus Erythematosus, Systemic
|
0.500 |
Biomarker
|
disease |
BEFREE |
We further detected five distinct inflammatory and metabolic pathways such as TWEAK, osteopontin, endochondral ossification, fluropyrimidine activity and urea cycle and metabolism of amino groups that significantly contribute to the pathogenesis of lupus (P < 0.05).
|
26403095 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In humans, typing of the +1239A/C single nucleotide polymorphism (SNP) in the 3UTR of the Opn gene (SPP1) showed that +1239C carriers displayed higher Opn serum levels than +1239A homozygotes and a higher risk of developing autoimmune/lymphoproliferative syndrome, multiple sclerosis, and systemic lupus erythematosus.
|
20378012 |
2010 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that, unlike the reported effect of the OPN SNP conferring predisposition to common diseases such as multiple sclerosis or systemic lupus erythematosus, these OPN gene polymorphisms do not contribute to RA susceptibility in the Spanish population we studied.
|
15742429 |
2005 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Conclusions Our meta-analysis revealed a significantly higher circulating OPN level in SLE patients, a trend of positive correlation between OPN levels and SLE activity, and a significant association between OPN 1239 C/A and 9250 C/T polymorphisms, and SLE development.
|
27307447 |
2017 |