|
Alkalemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Osteogenic markers as ALP, OPN, and OC mRNA were higher expressed in increasing pH values throughout osteoblastogenesis.
|
31531354 |
2019 |
|
Memory impairment
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Behavior tests showed impaired memory and learning ability in OPN<sup>-</sup> OPN<sup>+/+</sup> pups.
|
30199283 |
2019 |
|
Renal interstitial fibrosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CL treatment improved TAC-induced renal dysfunction and decreased renal interstitial fibrosis (reduced expression of e-cadherin and TGFβ-1) and interstitial inflammation (decreased infiltration of ED-1-positive and osteopontin-positive cells).
|
31200653 |
2019 |
|
Triphalangeal thumb
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, ZLN and TPT treatments are safe on carotid walls in osteoporotic women with subclinical atherosclerosis; circulating OPG and OPN are not affected by long-term anti-osteoporotic treatments and do not correlate with CA-IMT.
|
30791743 |
2019 |
|
Dyslipidemias
|
0.010 |
Biomarker
|
group |
BEFREE |
OPN and OPG positively correlated with greater systolic blood pressure (SBP) values, HOMA-IR and HOMA-β, and with the presence of dyslipidemia and carotid atherosclerosis.
|
30132286 |
2019 |
|
Chronic myocardial ischemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Osteopontin - a biomarker of disease, but also of stage stratification of the functional myocardial contractile deficit by chronic ischaemic heart disease.
|
30843743 |
2019 |
|
Acute heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
We highlight date from recent studies examining the use of novel biomarkers (micro RNAs, osteopontin, insulin-like growth-factor binding protein-7) for the diagnosis of AHF.
|
30547895 |
2019 |
|
Familial Cerebral Amyloid Angiopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
We propose that calcification of CAA vessels in the observed HCHWA-D cases may be induced by extracellular OPN trapped in the fibrotic Col1 vessel wall, independently of the presence of vascular amyloid.
|
30868685 |
2019 |
|
Hepatic methionine adenosyltransferase deficiency
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Increased matrix metalloproteinase-2 (MMP-2), osteopontin, and interleukin-6 expression was detected in HMet + PPE rats.
|
31307051 |
2019 |
|
Iron Overload
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Icariin could protect against iron overload-induced mitochondrial membrane potential dysfunction and ROS production, promote osteoblast survival and reverse the reduction of Runx2, alkaline phosphatase, and osteopontin expression induced by iron overload.
|
30387158 |
2019 |
|
Arteriovenous hemangioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of osteopontin, matrix metalloproteinase-2 and -9 proteins in vascular instability in brain arteriovenous malformation.
|
31275742 |
2019 |
|
Dissection of aorta
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to explore the relationship between osteopontin (OPN) and AD.
|
30626766 |
2019 |
|
Idiopathic osteoarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Genes involved in bone formation and mineralization, such as osteopontin (OPN) and Matrix Gla protein (MGP), could also be related with OA.
|
29777408 |
2019 |
|
Primary osteoporosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Bone metabolism-related molecules, such as alkaline phosphatase, matrix Gla protein, osteocalcin, osteopontin, and collagen type I; inflammatory cytokines, such as interleukin-1, -6, and tumor necrosis factor; and lipid metabolism related molecules, such as oxidized low density lipoprotein; mediate signaling in primary osteoporosis and vascular calcification.
|
28958683 |
2019 |
|
Aortic valve calcification
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>NEW & NOTEWORTHY</b> Our in vitro model of calcific aortic valve disease shows an interaction between the hyaluronic acid binding protein CD44 with the osteogenic factor OPN as a potential mechanism of aortic valve calcification.
|
30951363 |
2019 |
|
Hyperhomocysteinemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that impaired autophagy, as evidenced by decreased levels of MAP1LC3B II/MAP1LC3B I, has a vital role in HHcy-induced human aortic (HA)-VSMC phenotypic switching, with a decrease in contractile proteins (SM α-actin and calponin) and an increase in osteopontin.
|
31028566 |
2019 |
|
Neuropsychiatric Systemic Lupus Erythematosus
|
0.010 |
Biomarker
|
disease |
BEFREE |
OPN full in CSF could be a novel diagnostic marker for NPSLE.
|
30744522 |
2019 |
|
Arteriopathic disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Altogether, these data support that human OPN isoforms may represent novel therapeutic targets to improve neovascualrization and preserve tissue function in patients with obstructive artery diseases.
|
29959420 |
2019 |
|
Cardiomyopathies
|
0.010 |
Biomarker
|
group |
BEFREE |
The purpose of this study was to identify potential OPN targets in biopsies of HF patients, healthy control subjects, and human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs), and to characterize the cardiac phenotype of Col4a3<sup>-/-</sup> mice, relate this to HFpEF, and investigate possible causative roles for OPN in driving the cardiomyopathy.
|
31146816 |
2019 |
|
Arteriovenous Malformations, Cerebral
|
0.010 |
Biomarker
|
group |
BEFREE |
OPN and MMPs have been studied in brain arteriovenous malformation (BAVM) patients' tissues and blood samples before intervention.
|
31275742 |
2019 |
|
Transfusion-Related Acute Lung Injury
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using pulmonary immunohistochemistry, OPN could be specifically detected in the lungs of mice that suffered from TRALI.
|
31076444 |
2019 |
|
Heart valve calcification
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Serum osteopontin level is associated with heart valve calcification in HD patients, but there was no relationship found with FGF-23.
|
30369401 |
2019 |
|
Generalized osteoarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Genes involved in bone formation and mineralization, such as osteopontin (OPN) and Matrix Gla protein (MGP), could also be related with OA.
|
29777408 |
2019 |
|
Cerebral Amyloid Angiopathy, Hereditary
|
0.010 |
Biomarker
|
disease |
BEFREE |
We propose that calcification of CAA vessels in the observed HCHWA-D cases may be induced by extracellular OPN trapped in the fibrotic Col1 vessel wall, independently of the presence of vascular amyloid.
|
30868685 |
2019 |
|
Tumor-Associated Process
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
We noticed Secreted phosphoprotein 1 (SPP1) as one of the signature genes up-regulated in HCC tissues with a close relation to the tumor process.
|
31814897 |
2019 |