|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Six genes (JUN, HIST2H2BE, FOSB, FOS, EGR1, TCF4) were significantly upregulated in SCZ compared to control fibroblasts.
|
25658856 |
2015 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of schizophrenia in Ashkenazi Jews.
|
26198764 |
2015 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Most GWAS risk variations were reported to affect neuroimaging phenotypes implicated in SZ/BD: white-matter integrity (ANK3 and ZNF804A), volume (CACNA1C and ZNF804A) and density (ZNF804A); grey-matter (CACNA1C, NRGN, TCF4 and ZNF804A) and ventricular (TCF4) volume; cortical folding (NCAN) and thickness (ZNF804A); regional activation during executive tasks (ANK3, CACNA1C, DGKH, NRGN and ZNF804A) and functional connectivity during executive tasks (CACNA1C and ZNF804A), facial affect recognition (CACNA1C and ZNF804A) and theory-of-mind (ZNF804A); but inconsistencies and non-replications also exist.
|
25858580 |
2015 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Biological insights from 108 schizophrenia-associated genetic loci.
|
25056061 |
2014 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms in TCF4 gene have been consistently associated with schizophrenia in genome wide association studies, including the C allele of rs9960767.
|
24275585 |
2014 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that a SCZ risk variant in TCF4 is associated with neurophysiologic traits thought to index attention and working memory abnormalities in psychotic disorders.
|
24339136 |
2014 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
We measured the expression levels of the genes identified in GWAS (ZNF804A, OPCML, RPGRIP1L, NRGN, and TCF4) of the postmortem brain tissues of patients with schizophrenia and controls from two separate sample sets (i.e., the Australian Tissue Resource Center and Stanley Medical Research Institute).
|
24686180 |
2014 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Transcription factor 4 (TCF4) and schizophrenia: integrating the animal and the human perspective.
|
24413739 |
2014 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
PSYGENET |
The analyses on the 28 individual SNPs previously associated with schizophrenia found that two SNPs in TCF4 returned a significant association with the SPEQ Paranoia dimension, rs17512836 (p-value = 2.57×10⁻⁴) and rs9960767 (p-value = 6.23×10⁻⁴).
|
24718684 |
2014 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The analyses on the 28 individual SNPs previously associated with schizophrenia found that two SNPs in TCF4 returned a significant association with the SPEQ Paranoia dimension, rs17512836 (p-value = 2.57×10⁻⁴) and rs9960767 (p-value = 6.23×10⁻⁴).
|
24718684 |
2014 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms (SNPs) within the MIR137, TCF4, and ZNF804A genes show genome-wide association to schizophrenia.
|
25217366 |
2014 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
PSYGENET |
No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure.
|
25217366 |
2014 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
PSYGENET |
Single nucleotide polymorphisms in TCF4 gene have been consistently associated with schizophrenia in genome wide association studies, including the C allele of rs9960767.
|
24275585 |
2014 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies have identified common variants in transcription factor 4 (TCF4) as susceptibility loci for schizophrenia, Fuchs' endothelial corneal dystrophy, and primary sclerosing cholangitis.
|
24594265 |
2014 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
We investigated the expression levels of miR-137 and three candidate target genes (ZNF804A, CACNA1C, TCF4) in the DLPFC of postmortem brain tissue from 2 independent cohorts: (1) 26 subjects (10 control (CTR), 7 schizophrenia (SZ), 9 bipolar disorder (BD)) collected at the UCI brain bank; and (2) 99 subjects (33 CTR, 35 SZ, 31 BD) obtained from the Stanley Medical Research Institute (SMRI).
|
23786914 |
2013 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
In this review, we present a systematic bioinformatics and literature review of the genomics, biological function and interactome of TCF4 in the context of schizophrenia.
|
23129290 |
2013 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
PSYGENET |
Genome-wide association studies have also found that common variants in TCF4 are associated with an increased risk of schizophrenia.
|
24058414 |
2013 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
A comprehensive family-based replication study of schizophrenia genes.
|
23894747 |
2013 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
|
23453885 |
2013 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The TCF4 gene is also a risk factor with highly significant linkage to schizophrenia, presumably via overexpression of the TCF4 gene product in the central nervous system.
|
23640545 |
2013 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Associations between TCF4 gene polymorphism and cognitive functions in schizophrenia patients and healthy controls.
|
23249814 |
2013 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
A comprehensive family-based replication study of schizophrenia genes.
|
23894747 |
2013 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies have also found that common variants in TCF4 are associated with an increased risk of schizophrenia.
|
24058414 |
2013 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We replicated SNPs in TCF4 (P = 2.53 x 10(-10)) and NOTCH4 (P = 3.16 x 10(-7)) that are among the most robust SCZ findings.
|
23894747 |
2013 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
For this purpose, we genotyped the schizophrenia-associated risk variants within zinc-finger protein 804A (ZNF804A), transcription-factor 4 and neurogranin in a large dyslexia case-control sample.
|
22781169 |
2012 |