|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Isolation of a novel human gene, APCDD1, as a direct target of the beta-Catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis.
|
12384519 |
2002 |
|
Carcinogenesis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
It was found that mutations in the TCF-4 A(9) repeat do not contribute to tumorigenesis and seem to be passenger mutations.
|
12036905 |
2002 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Finally, genetic aberrations of several components of the beta-catenin pathways, eg, Frizzled (Frz), AXIN, and TCF-4, may potentially contribute to colorectal carcinogenesis.
|
11839557 |
2002 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of hTcf-4 gene expression and mutation with clinicopathological characteristics of hepatocellular carcinoma.
|
12378619 |
2002 |
|
Neoplasm Metastasis
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, hTcf-4 gene expression was closely associated with tumor capsule status and intrahepatic metastasis of HCC.
|
12378619 |
2002 |
|
Adenomatous Polyposis Coli
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
The activation of the pathway was mainly due to the mutation of adenomatous polyposis coli (APC) or beta-catenin, and Tcf-4 was highly expressed in these cell lines with upregulated signaling.
|
12460462 |
2002 |
|
Astrocytoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, an in vitro functional assay showed that S73F and S23G mutants of beta-catenin did not affect transcriptional activity in TCF-4-leuciferase reporter construct, suggesting that they may need more complex factors to participate in astrocytoma.
|
12049819 |
2002 |
|
Childhood Astrocytoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, an in vitro functional assay showed that S73F and S23G mutants of beta-catenin did not affect transcriptional activity in TCF-4-leuciferase reporter construct, suggesting that they may need more complex factors to participate in astrocytoma.
|
12049819 |
2002 |
|
Colorectal Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
APC, beta-Catenin and hTCF-4; an unholy trinity in the genesis of colorectal cancer.
|
12633551 |
2003 |
|
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our present findings strongly suggest mutations of beta-catenin as well as over expression of beta-catenin and Tcf-4 gene activate the Wnt pathway in HCC independently with the target gene most likely to be C-myc.
|
14687479 |
2003 |
|
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
On analyzing the relationship between alterations of beta-catenin or Tcf-4 and C-myc or Cyclin D1 expression, we found that mutations of beta-catenin, as well as overexpression of beta-catenin or the Tcf-4 gene were independently correlated with C-myc gene overexpression in HCC.
|
12603528 |
2003 |
|
Malignant neoplasm of colon and/or rectum
|
0.100 |
Biomarker
|
disease |
BEFREE |
APC, beta-Catenin and hTCF-4; an unholy trinity in the genesis of colorectal cancer.
|
12633551 |
2003 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
We also analyzed the relationship between TCF-4 gene splicing isoforms, proliferation (proliferating cell nuclear antigen labeling index), and apoptosis [antiapoptotic factors (Bcl-2 and Bcl-x(L)), proapoptotic factors (Bak and Bax), and caspase-3] in RCC samples.
|
12796377 |
2003 |
|
Renal Cell Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
We also analyzed the relationship between TCF-4 gene splicing isoforms, proliferation (proliferating cell nuclear antigen labeling index), and apoptosis [antiapoptotic factors (Bcl-2 and Bcl-x(L)), proapoptotic factors (Bak and Bax), and caspase-3] in RCC samples.
|
12796377 |
2003 |
|
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
To further understand the roles played by differential expression and splicing isoforms of human Tcf-4 in brain tumorigenesis, the expression of the 3' part of the Tcf-4 gene (exons 10-17) was analyzed by RT-PCR, nested RT-PCR and DNA sequencing.
|
15547706 |
2004 |
|
Brain Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The results showed that at least 13 of the Tcf-4 alternative splicing isoforms were found and most of them were overexpressed in various brain tumors.
|
15547706 |
2004 |
|
Colorectal Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
This is the first description of the downregulation of HOXB13 in CRC and its mechanism of action is mediated through the regulation of TCF4 protein stability.
|
15928669 |
2005 |
|
Malignant tumor of colon
|
0.480 |
Biomarker
|
disease |
BEFREE |
Recently, the role of TCF-4 has been described in colon cancer and other cancers.
|
15667799 |
2005 |
|
Adenocarcinoma
|
0.310 |
Biomarker
|
group |
BEFREE |
Furthermore, there was a significant difference in TCF-4 localization patterns between squamous cell carcinomas and adenocarcinomas (P < 0.05).
|
15667799 |
2005 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
TCF-4 mRNA expression was significantly higher in tumors with moderate-poor cell differentiation than in well differentiated tumors (P < 0.05).
|
15667799 |
2005 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
T cell factor-4 (TCF-4) plays an important role in development and carcinogenesis.
|
15667799 |
2005 |
|
Malignant neoplasm of lung
|
0.080 |
Biomarker
|
disease |
BEFREE |
However, whether TCF-4 plays a similar role in lung cancer is unknown.
|
15667799 |
2005 |
|
Carcinoma of lung
|
0.080 |
Biomarker
|
disease |
BEFREE |
However, whether TCF-4 plays a similar role in lung cancer is unknown.
|
15667799 |
2005 |
|
Colon Carcinoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
Recently, the role of TCF-4 has been described in colon cancer and other cancers.
|
15667799 |
2005 |
|
Primary malignant neoplasm of lung
|
0.080 |
Biomarker
|
disease |
BEFREE |
However, whether TCF-4 plays a similar role in lung cancer is unknown.
|
15667799 |
2005 |