|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Linagliptin significantly improved hyperglycaemia in patients with type 2 diabetes both with and without the TCF7L2 gene diabetes risk alleles.
|
24906949 |
2014 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
TCF7L2 type 2 diabetes susceptibility alleles are associated with islet autoantibody-negative but not autoantibody-positive new onset diabetes in young patients.
|
19050058 |
2009 |
|
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
However, the mechanism(s) by which TCF7L2 predisposes to diabetes remain uncertain.
|
29993315 |
2018 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In the DESIR cohort, a parental history of diabetes and the TCF7L2 at-risk variant were both associated with hypertension incidence at year 9, independently of waist circumference, BP, fasting glucose, insulin levels and HOMA-IR at inclusion (p = 0.02 for parental history, p = 0.006 for TCF7L2).
|
23942764 |
2013 |
|
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
LADA shares genetic features with both type 1 (HLA, INS VNTR, and PTPN22) and type 2 (TCF7L2) diabetes, which justifies considering LADA as an admixture of the two major types of diabetes.
|
18310307 |
2008 |
|
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
Transcription factor 7-like 2 (TCF7L2) is a gene that is related to the development of diabetes.
|
18806947 |
2009 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that patients with diabetes risk alleles in TCF7L2 have an altered hypoglycaemic response to SUs resulting in earlier secondary failure.
|
21349175 |
2011 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In this study, we aimed to confirm the effect of the TCF7L2 polymorphism rs7903146 on diabetes risk in a Brazilian population and to assess the use of this genetic marker in improving diabetes risk prediction in the general population.
|
19055834 |
2008 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We genotyped four single nucleotide polymorphisms (SNPs) of TCF7L2 (rs7901695, rs7903146, rs11196205 and rs12255372) in 831 subjects with diabetes and 437 control subjects.
|
18291022 |
2008 |
|
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
TCF7L2 therefore appears as a genetic link between diabetes and atherosclerosis.
|
21423583 |
2011 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to investigate the possible association between diabetes susceptibility gene transcription factor 7-like 2 (TCF7L2) and gestational diabetes mellitus (GDM) in a Chinese Han population.
|
27465520 |
2016 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to elucidate which variant in TCF7L2 confers diabetes susceptibility in African Americans.
|
20980453 |
2011 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To further determine whether variation in Tcf7l2 expression may lead to diabetes, we developed a Tcf7l2 copy-number allelic series in mice.
|
21673050 |
2011 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We assessed five single nucleotide polymorphisms (SNPs) in TCF7L2 including the putative SNP (rs7903146) for diabetes.
|
18268068 |
2008 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Controlling for diabetes status, participants with the TT genotype of TCF7L2 (n= 12) performed worse on tests of attention/executive function/processing speed than those with the CC (n= 46) and CT (n= 53) genotypes, despite no between-group differences in demographic or medical variables.
|
22712642 |
2012 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Thus, diabetes-associated TCF7L2 gene variation predicts the success of lifestyle intervention in terms of weight loss and determines individual susceptibility toward environmental factors.
|
20028944 |
2010 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Associations between TCF7L2 SNP and diabetic complications and diabetes-related factors were investigated.
|
24529562 |
2014 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
All subjects were genotyped for the previously described TCF7L2 diabetes risk variants.
|
18702948 |
2008 |
|
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
TCF7L2 Genotype and α-Cell Function in Humans Without Diabetes.
|
26525881 |
2016 |
|
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
We have confirmed TCF7L2 to be a diabetes locus in a large case-control study in Tayside, UK.
|
17429603 |
2007 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association between the TCF7L2 rs7903146 polymorphism and incident IFG defined as fasting serum glucose levels of 100-125 mg/dL (5.6-6.9 mmol/L) in 1377 African American and 5152 Caucasian participants without diabetes and IFG at intake who participated in the Atherosclerosis Risk in Communities (ARIC) Study from 1987 to 1989 and were followed for 9 years.
|
20578204 |
2010 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Allele-specific PCR assay to genotype SNP rs7903146 in TCF7L2 gene for rapid screening of diabetes susceptibility.
|
19169495 |
2008 |
|
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
TCF7L2 diabetes risk variants, either as single-nucleotide polymorphisms or as haplotypes, detrimentally influence β-cell function and might play a role in determining the metabolic phenotype of patients with newly diagnosed type 2 diabetes.
|
21159844 |
2011 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
T2D-related variants HHEX rs7923837, TCF7L2 rs290481 and CDKAL1 rs7756992 increased cancer risk in patients with diabetes.
|
24468095 |
2014 |
|
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
In this study, we discovered a previously unrecognized role for Tcf7l2, a transcription factor known as the canonical Wnt nuclear effector and diabetes risk-conferring gene, in establishing neuronal identity and circuits of the caudal forebrain.
|
28219675 |
2017 |