|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Effects of the diabetes linked TCF7L2 polymorphism in a representative older population.
|
17181866 |
2006 |
|
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
These findings suggest that TCF7L2 is a central node in the regulation of human diabetes and other disease-associated genes.
|
20640398 |
2010 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We analysed the recently reported type 2 diabetes (T2D) associated polymorphisms in the TCF7L2 gene using a case-control approach, under the hypothesis that TCF7L2 variants should show similar association if diabetes in FCPD is similar to T2D.
|
18706099 |
2008 |
|
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
In the near future, large-scale genome-wide association studies will fully extend the genome coverage, potentially delivering other common diabetes-susceptibility genes like TCF7L2.
|
17476472 |
2007 |
|
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
Findings support an association between TCF7L2 and breast cancer and history of diabetes modifies this association for specific variants.
|
23085767 |
2012 |
|
Diabetes
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
TCF7L2 is a transcription factor in the canonical Wnt pathway, involved in multiple disorders, including diabetes, cancer and psychiatric conditions.
|
26934194 |
2016 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the ability of hyperglycemia to suppress glucagon (45 ± 2 vs. 47 ± 2 vs. 60 ± 5 ng/L for CC, CT, and TT, respectively, P = 0.02).
|
22461567 |
2012 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to ascertain the polymorphic markers profile of ADIPOQ, KCNJ11 and TCF7L2 genes in Kyrgyz population and to analyze the association of polymorphic markers and combinations of ADIPOQ gene's G276T locus, KCNJ11 gene's Glu23Lys locus and TCF7L2 gene's VS3C>T locus with type two diabetes (T2D) in Kyrgyz population.
|
30467975 |
2019 |
|
Diabetes
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
In addition to its recently recognized role in diabetes, aberrant TCF7L2 expression has been implicated in cancer through regulation of cell proliferation and apoptosis by c-MYC and cyclin D. It has been hypothesized that germline variants within the TCF7L2 gene previously associated with diabetes may affect cancer risk through the Wnt/beta-catenin signaling pathway.
|
18302196 |
2008 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This study was conducted to evaluate an association between TCF7L2 variants and diabetes susceptibility in the population of Latvia.
|
22441719 |
2012 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes.
|
26914832 |
2016 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The Role of TCF7L2 rs7903146 in Diabetes After Kidney Transplant: Results From a Single-Center Cohort and Meta-Analysis of the Literature.
|
26555947 |
2016 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This study indicates that variants in the TCF7L2 gene significantly contribute to diabetes susceptibility in African-American populations.
|
17601994 |
2007 |
|
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
The transcription factor 7-like 2 (TCF7L2) has been recently associated with diabetes risk, and it may exert its effect through metabolic syndrome (MetS)-related traits and be subjected to modification by environmental factors.
|
19141698 |
2009 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
An interaction (p = 0.048) between TCF7L2 variants and coffee intake was apparent, with an inverse association between coffee and type 2 diabetes present among carriers of the diabetes risk allele (T) in rs12255372 (GG: HR 0.99 [95% CI 0.97, 1.02] per cup of coffee; GT: HR 0.96 [95% CI 0.93, 0.98]); and TT: HR 0.93 [95% CI 0.88, 0.98]).
|
27623947 |
2016 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, several population-based samples suggest that variants in the TCF7L2 gene are associated with reduced kidney function or CKD progression, overall and specifically among participants without diabetes.
|
18650481 |
2008 |
|
Diabetes
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
In this issue of the JCI, Lyssenko and colleagues report on their human and isolated islet studies and suggest that the risk allele increases TCF7L2 expression in the pancreatic beta cell, reducing insulin secretion and hence predisposing the individual to diabetes (see the related article beginning on page 2155).
|
17671643 |
2007 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Of 100K SNPs, one (rs7100927) was in moderate LD (r2 = 0.50) with TCF7L2 (rs7903146), and was associated with risk of diabetes (Cox p-value 0.007, additive hazard ratio for diabetes = 1.56) and with tFPG (GEE p-value 0.03).
|
17903298 |
2007 |
|
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
Here we show that the diabetes-associated gene Tcf7l2 is densely expressed in the medial habenula (mHb) region of the rodent brain, where it regulates the function of nicotinic acetylcholine receptors.
|
31619789 |
2019 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our study provides the first significant evidence of association between the TCF7L2 rs7903146 polymorphism and type 2 diabetes risk in a large African American population and also demonstrates that the diabetes risk conveyed by the rs7903146 risk allele is substantially increased in the context of some metabolic risk factors for type 2 diabetes.
|
18931037 |
2009 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in TCF7L2 rs7903146 and history of GDM negatively and independently impact on diabetes-associated metabolic traits.
|
30419301 |
2018 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In the family-based study, variation in TCF7L2 increased the risk of diabetes about three-fold (HR 1.75 per allele, 95% CI 1.3-2.4; p = 0.0006), and decreased the mean age at diabetes diagnosis by 7 years.
|
19585101 |
2009 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These polymorphisms together with KCNJ11 (Kir6.2)-E23K and TCF7L2-rs7903146 may predict diabetes incidence in the DESIR cohort.
|
17977958 |
2008 |
|
Diabetes
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Our findings thus propose a potential cellular mechanism through which abnormal TCF7L2 activity predisposes individuals to diabetes and implicates abnormalities in the islet microenvironment in this disease.
|
29246974 |
2018 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We reproduced the association of diabetes-associated variants with proinsulin/insulin ratios, and also examined the association of a TCF7L2 haplotype with obesity in the Framingham Heart Study (FHS).
|
19183934 |
2009 |