Disease: Multiple Sclerosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 GeneticVariation disease BEFREE The same TCR (N)Dbeta(N)Jbeta junctional region is associated with several different vbeta13 subtypes in a multiple sclerosis patient at the onset of the disease. 14678763 2003
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 GeneticVariation disease BEFREE In data-sets derived from the Finnish population we found no evidence for contribution of the T-cell receptor beta chain (TCR beta chromosome 7q35), immunoglobulin heavy chain (IGH chromosome 14q32), interferon-gamma (IFN-gamma chromosome 12q14-q15) or interleukin-1 receptor antagonist/interleukin-1 beta (IL-1ra/IL-1 beta chromosome 2q14-q21) loci in the genetic susceptibility to MS. 9357444 1997
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 GeneticVariation disease BEFREE One strategy was to sequence TCR gene rearrangements directly from MS lesions. 7544077 1995
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 GeneticVariation disease BEFREE Consistent with a polygenic model for disease predisposition, MHC and TCR gene associations with MS are relatively weak. 8230601 1993
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 GeneticVariation disease BEFREE Out of 16 MBP-specific clones derived from a single MS patient, 12 clones (75%) utilized the V beta 15 gene for their TCR gene rearrangement. 1706524 1991
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 GeneticVariation disease BEFREE Of the CDR2 peptides, the substituted (Y49T)BV5S2-38-58 peptide was the most immunogenic but cross-reacted with the native sequence and had the strongest binding affinity for MS-associated HLA-DR2 alleles, suggesting that position 49 is an MHC rather than a TCR contact residue. 9670985 1998
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 GeneticVariation disease BEFREE Our results do not support suggestions that germline TCR alpha chain genes contribute to genetic susceptibility in MS. 1387654 1992
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 GeneticVariation disease BEFREE Although a family study has suggested linkage of susceptibility to MS to TcR genes, reports of disease associations with restriction fragment length polymorphism (RFLP)-defined alleles of TcR genes have been difficult to confirm, including a report of association of MS with TcR beta-chain gene RFLPs. 1346471 1992
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 GeneticVariation disease BEFREE This study provided experimental evidence suggesting a limited heterogeneity in TCR Valpha gene rearrangements of MBP-reactive T cells in DR2 patients with MS. 9701037 1998
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 GeneticVariation disease BEFREE Particular HLA genotypes may be associated with MS and recently also polymorphisms in the T-cell receptor (TCR) genes have been reported to correlate with the disease; however, these data have been difficult to confirm. 7911477 1994
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 GeneticVariation disease BEFREE Analysis of TCR gene rearrangements has established some of the target antigens of the immune response in MS. Environmental influences on MS are described with particular attention given to how microbes might trigger demyelinating disease. 10735270 1997
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 GeneticVariation disease BEFREE TCR beta polymorphisms and multiple sclerosis. 15175643 2004
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 GeneticVariation disease BEFREE These results demonstrate that a gene within the TCR beta complex or a closely linked locus influences susceptibility to MS. 2567636 1989
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 GeneticVariation disease BEFREE Although SNPs implicating each of these regions of interest will require genotyping in independent replication cohorts, these findings suggest a role for TCR gene polymorphisms in MS susceptibility. 21270827 2011
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 GeneticVariation disease BEFREE In order to establish whether such T cell responses are likely to be antigen-specific particularly with regard to myelin basic protein (MBP), we analysed T-cell receptor (TCR) gene rearrangements directly from MS brain plaques, using the polymerase chain reaction on reverse transcribed messenger RNA, and compared these with TCR of previously described MBP-specific T cell clones from MS and the rat model experimental allergic encephalomyelitis. 7680433 1993
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 Biomarker disease BEFREE CD8+ clones showed homology to published TCR from CNS-infiltrating T-cells in MS lesions. 21397340 2011
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 Biomarker disease BEFREE We suggest that the accumulation of highly antigen-sensitive EBNA1-specific Th1 cells in multiple sclerosis is capable of sustaining autoimmunity by cross-recognition of autoantigens or by TCR-independent bystander mechanisms. 16569670 2006
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 Biomarker disease BEFREE Interestingly, some sequences resembled published oligoclonal CD8+ TCR sequences from MS lesions. 16935352 2006
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 Biomarker disease BEFREE Pharmacological blockade of α<sub>1</sub>-adrenoceptor is shown to influence development of experimental autoimmune encephalomyelitis (EAE), an IL-17-producing CD4+TCR+ (Th17) cell-mediated disease mimicking multiple sclerosis. 31396845 2019
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 Biomarker disease BEFREE Here we analyse the role of TCR genes in MS by comparing TCR usage in discordant versus concordant monozygotic twins in response to self and foreign antigens. 7686632 1993
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 Biomarker disease BEFREE Differential expression of NK T cell V alpha 24J alpha Q invariant TCR chain in the lesions of multiple sclerosis and chronic inflammatory demyelinating polyneuropathy. 10754338 2000
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 Biomarker disease BEFREE TCR gene usage is also restricted in experimental autoimmune disease, in T cells within organs like skin and other epithelial tissues, and in the brain of patients with multiple sclerosis (MS). 2382141 1990
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 Biomarker disease BEFREE These findings do not support a direct role of TCR alpha in the inheritance of MS. 1348852 1992
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 Biomarker disease BEFREE In this study, we examined anti-idiotypic immune responses and the functional properties of anti-idiotypic T cells in patients with MS and healthy controls using TCR peptides corresponding to a CDR3 sequence motif preferentially expressed among T cells recognizing the 83-99 immunodominant peptide of MBP in some patients with MS. 12917259 2003
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 Biomarker disease BEFREE The role of CD28 in multiple sclerosis (MS) has been evaluated as the source of costimulatory signals integrating those delivered by TCR. 24412596 2014