|
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The same TCR (N)Dbeta(N)Jbeta junctional region is associated with several different vbeta13 subtypes in a multiple sclerosis patient at the onset of the disease.
|
14678763 |
2003 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD8+ clones showed homology to published TCR from CNS-infiltrating T-cells in MS lesions.
|
21397340 |
2011 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We suggest that the accumulation of highly antigen-sensitive EBNA1-specific Th1 cells in multiple sclerosis is capable of sustaining autoimmunity by cross-recognition of autoantigens or by TCR-independent bystander mechanisms.
|
16569670 |
2006 |
|
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In data-sets derived from the Finnish population we found no evidence for contribution of the T-cell receptor beta chain (TCR beta chromosome 7q35), immunoglobulin heavy chain (IGH chromosome 14q32), interferon-gamma (IFN-gamma chromosome 12q14-q15) or interleukin-1 receptor antagonist/interleukin-1 beta (IL-1ra/IL-1 beta chromosome 2q14-q21) loci in the genetic susceptibility to MS.
|
9357444 |
1997 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, some sequences resembled published oligoclonal CD8+ TCR sequences from MS lesions.
|
16935352 |
2006 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pharmacological blockade of α<sub>1</sub>-adrenoceptor is shown to influence development of experimental autoimmune encephalomyelitis (EAE), an IL-17-producing CD4+TCR+ (Th17) cell-mediated disease mimicking multiple sclerosis.
|
31396845 |
2019 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we analyse the role of TCR genes in MS by comparing TCR usage in discordant versus concordant monozygotic twins in response to self and foreign antigens.
|
7686632 |
1993 |
|
Multiple Sclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To better characterize the inflammatory response that occurs in the nervous system in multiple sclerosis (MS), T-cell receptor (TCR) gene expression was quantified from cerebrospinal fluid (CSF) cells of 21 patients with active disease.
|
8892095 |
1996 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Differential expression of NK T cell V alpha 24J alpha Q invariant TCR chain in the lesions of multiple sclerosis and chronic inflammatory demyelinating polyneuropathy.
|
10754338 |
2000 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
TCR gene usage is also restricted in experimental autoimmune disease, in T cells within organs like skin and other epithelial tissues, and in the brain of patients with multiple sclerosis (MS).
|
2382141 |
1990 |
|
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
One strategy was to sequence TCR gene rearrangements directly from MS lesions.
|
7544077 |
1995 |
|
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Consistent with a polygenic model for disease predisposition, MHC and TCR gene associations with MS are relatively weak.
|
8230601 |
1993 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings do not support a direct role of TCR alpha in the inheritance of MS.
|
1348852 |
1992 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we examined anti-idiotypic immune responses and the functional properties of anti-idiotypic T cells in patients with MS and healthy controls using TCR peptides corresponding to a CDR3 sequence motif preferentially expressed among T cells recognizing the 83-99 immunodominant peptide of MBP in some patients with MS.
|
12917259 |
2003 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The role of CD28 in multiple sclerosis (MS) has been evaluated as the source of costimulatory signals integrating those delivered by TCR.
|
24412596 |
2014 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ex vivo detection of myelin basic protein-reactive T cells in multiple sclerosis and controls using specific TCR oligonucleotide probes.
|
14991617 |
2004 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
TCR repertoire and cytokine profiles of cerebrospinal fluid- and peripheral blood-derived T lymphocytes from patients with multiple sclerosis.
|
9545089 |
1998 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we validate these cellular immune responses by characterizing TCR peptide specific T cells from an MS patient with biased V beta 5.2 expression in BP reactive T cells before treatment with TCR peptides, and from two MS patients in whom the frequencies of anti-TCR peptide specific T cells were significantly boosted after injection with low doses of TCR peptides.
|
7510747 |
1994 |
|
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Out of 16 MBP-specific clones derived from a single MS patient, 12 clones (75%) utilized the V beta 15 gene for their TCR gene rearrangement.
|
1706524 |
1991 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The object of the study is a comparison of intrathecal IgG synthesis and gamma/delta TCR genes rearrangement in multiple sclerosis.
|
10464430 |
1999 |
|
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Of the CDR2 peptides, the substituted (Y49T)BV5S2-38-58 peptide was the most immunogenic but cross-reacted with the native sequence and had the strongest binding affinity for MS-associated HLA-DR2 alleles, suggesting that position 49 is an MHC rather than a TCR contact residue.
|
9670985 |
1998 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A common TCR V-D-J sequence in V beta 13.1 T cells recognizing an immunodominant peptide of myelin basic protein in multiple sclerosis.
|
10477628 |
1999 |
|
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results do not support suggestions that germline TCR alpha chain genes contribute to genetic susceptibility in MS.
|
1387654 |
1992 |
|
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although a family study has suggested linkage of susceptibility to MS to TcR genes, reports of disease associations with restriction fragment length polymorphism (RFLP)-defined alleles of TcR genes have been difficult to confirm, including a report of association of MS with TcR beta-chain gene RFLPs.
|
1346471 |
1992 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the effects of age and gut dysbiosis on the development of CNS autoimmunity in humanized transgenic mice expressing the MS-associated MHC class II (MHC-II) gene, HLA-DR2a, and T-cell receptor (TCR) genes specific for MBP87-99/DR2a that were derived from an MS patient.
|
29078267 |
2017 |