|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
One of these PCR assays was based on amplification of leukemia-specific TCR-delta gene rearrangements, while the other assay relied upon detection of the c-tal deletion.
|
8182934 |
1994 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, a correlation between T-cell receptor (TCR) gene rearrangements and chromosomal aberrations has been implicated in this leukemia.
|
7510355 |
1994 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Since this patient represents a de novo acute leukemia as evaluated by location of the translocation-breakpoint on chromosome 22, our data clearly indicate that Ig- and TCR gene rearrangements might prove a valuable addition in monitoring Ph1+ hybrid leukemias, providing guidelines for optimizing chemotherapy.
|
1312481 |
1992 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In order better to characterize this type of leukaemia, we have investigated the immunoglobulin (Ig) and T-cell receptor (TCR) genes configuration of 21 infants with ALL, and compared the genotypic features with the phenotypic and karyotypic data, as well as with the clinical outcome.
|
1316141 |
1992 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Four of five TCR tau delta+ leukemias carried rearrangements of the C tau 2 gene, and transcribed the T-early alpha genetic element.
|
1826854 |
1991 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The pattern of immunoglobulin (Ig) and T cell receptor (TCR) gene rearrangements was determined in 87 patients with acute and chronic leukaemias and myelodysplastic syndromes by Southern blot hybridisation.
|
1850943 |
1991 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
To gain a better understanding of the organization of the complex T-cell antigen receptor alpha/delta (TCR alpha/delta) locus, a deletional analysis using the known six variable (V) regions of the TCR delta was performed in informative leukemic cell lines and fresh leukemias.
|
1832201 |
1991 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, despite their putative "B-cell precursor" lineage, these leukemias manifest a remarkably high incidence of TCR gene rearrangements.
|
2307988 |
1990 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have sought to address the question of clonal variation of TCR within a human T leukemia cell line, HPB-ALL.
|
3262674 |
1988 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
A previously established human leukemia cell line, designated THP-6, was further characterized with respect to cell surface antigen expression and immunoglobulin(Ig) and T-cell receptor(TCR) gene status.
|
3130528 |
1988 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nine patients had acute lymphoblastic leukaemia (T-ALL), nine patients had prolymphocytic leukaemia (PLL), six patients presented with a T-CLL/T-lymphocytosis syndrome, two patients had Sezary syndrome (SS) and one patient had HTLV-I positive T-cell leukaemia/lymphoma (ATLL). alpha TCR gene rearrangement could be demonstrated by the use of three available probes in only one case.
|
2961364 |
1987 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Inappropriately rearranged IgH or TCR genes are usually not expressed at the mRNA level, and the gene for the TCR associated protein T3 delta is not detectably expressed at the mRNA or protein level in leukemias classified unambiguously as non-T. Five cases of acute leukemia with ambiguous or mixed lineage immunophenotypes (myeloid + T or myeloid + B) are described.
|
3118113 |
1987 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our cytogenetic analysis of one such cell line, SUP-T3, demonstrates that the breakpoints on chromosomes 7 and 9 lie within bands q36 and q34, respectively, corresponding to the location of the gene encoding the beta chain of the T-cell receptor, TCRB, and the gene homologous to the transforming gene of the Abelson murine leukemia virus, ABL.
|
3025859 |
1987 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Neither TCR gene was found to be rearranged in acute nonlymphoid leukemia patients (0/12) or in patients with B-cell (surface immunoglobulin-positive) leukemia (0/3).
|
2955409 |
1987 |