|
Iron deficiency
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Erythrocytic Iron Deficiency Enhances Susceptibility to Plasmodium chabaudi Infection in Mice Carrying a Missense Mutation in Transferrin Receptor 1.
|
26303393 |
2015 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Malaria exacerbates inflammation-associated elevation in ferritin and soluble transferrin receptor with only modest effects on iron deficiency and iron deficiency anaemia among rural Zambian children.
|
29121448 |
2018 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, induction of more severe iron deficiency in human trophoblast in vitro resulted in the regulation of both TFR1 and FPN, similar to what was observed in the mouse model.
|
31661462 |
2020 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent studies have provided immunological evidence for the existence of transferrin receptor in human serum and have revealed that its concentration is a sensitive measure of erythropoiesis and iron deficiency.
|
2229063 |
1990 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
In children with anaemia, rates of iron deficiency (low ferritin based on inflammation status, and/or high soluble transferrin receptor, ≥1.97 mg/L) and zinc deficiency (serum zinc <65 μg/dl) were 81.1% and 53.7%, respectively.
|
31595712 |
2020 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Iron deficiency was identified with transferrin receptor in archived dried blood spots (TfR > 5.0 mg/l).
|
28832929 |
2017 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
The soluble transferrin receptor is a truncated form of the cellular transferrin receptor and the possible value of this measurement in the diagnosis of iron deficiency will be discussed.
|
14633776 |
2003 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study is aimed at investigating ID with conventional (ferritin, transferrin saturation [TSAT]) and new biomarkers (soluble transferrin receptor [sTfR], sTfR/log ferritin, reticulocyte hemoglobin content [CHr], hepcidin-25) in patients sub-grouped by the presence or absence of H. pylori infection.
|
31154451 |
2019 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
TfR1 was localized in the crypts in controls but also in the villi with iron deficiency.
|
15054143 |
2004 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Soluble transferrin receptor (sTfR) is a cleaved monomer of transferrin receptor 1 and correlates positively with tissue iron deficiency as well as with stimulated erythropoiesis.
|
26522463 |
2015 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Soluble transferrin receptor/log ferritin index was significantly higher in iron deficiency anemia (median: 1.76) than in anemia of chronic disease (median: 0.55), anemia of chronic disease with iron deficiency (median: 0.68) or patients without anemia (median: 0.72).
|
30538074 |
2019 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum ferritin, soluble transferrin receptor, and total body iron for the detection of iron deficiency in early pregnancy: a multiethnic population-based study with low use of iron supplements.
|
30831600 |
2019 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Iron depletion (serum ferritin <15ug/ml) occurred in 19.2% and cellular iron deficiency (low serum ferritin and transferrin receptor >28.1 nmol/l) in 11.6% students.
|
29155855 |
2017 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Iron deficiency prevalence (inflammation-corrected ferritin <15 μg/L or soluble transferrin receptor >8.3 mg/L) was 67%; anemia was 36%, and vitamin D insufficiency (25(OH)D <30 ng/mL) was 77%.
|
28700535 |
2017 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we evaluated potential associations of tryptophan, kynurenine, and kynurenic acid with indicators of iron metabolism (i.e., mean corpuscular volume, mean corpuscular haemoglobin, ferritin, transferrin saturation, serum iron, transferrin, soluble transferrin receptor, reticulocyte haemoglobin) and haemoglobin in 430 individuals grouped by the presence or absence of iron deficiency or anaemia.
|
31601941 |
2019 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
A positive association between ferroportin and TFRC mRNA, a gene associated with intracellular iron deficiency, was observed only in granulosa cells from fertile women.
|
27842994 |
2017 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Soluble transferrin receptor may be a reliable marker of ID in HIV-mediated inflammation.
|
29943722 |
2018 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression of the putative stimulator of Fe transport and TfR increases in iron deficiency.
|
11313310 |
2001 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Background:</b> Total-body iron stores (TBI), which are calculated from serum ferritin and soluble transferrin receptor concentrations, can be used to assess the iron status of populations in the United States.<b>Objective:</b> This analysis, developed to support workshop discussions, describes the distribution of TBI and the prevalence of iron deficiency (ID) and ID anemia (IDA) among toddlers, nonpregnant females, and pregnant females.<b>Design:</b> We analyzed data from NHANES; toddlers aged 12-23 mo (NHANES 2003-2010), nonpregnant females aged 15-49 y (NHANES 2007-2010), and pregnant females aged 12-49 y (NHANES 1999-2010).
|
29070559 |
2017 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
From a cohort of children (n = 820), 4-8 years of age participating in a randomized controlled trial of pro-vitamin A, we estimated attributable fractions for anemia (hemoglobin of <110 or 115 g/L, by age) owing to current malaria or inflammation (C-reactive protein of >5 mg/L, or α-1 acid glycoprotein of >1 g/L, or both), and current or prior iron deficiency (ID; defined as low ferritin [<12 or 15 μg/L for age <5 or >5 years] or functional ID [soluble transferrin receptor of >8.3 mg/L] or both) and vitamin A deficiency (retinol of <0.7 μmol/L), during low and high malaria seasons, using multivariate logistic regression.
|
31402145 |
2019 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Iron deficiency was quantifies as the serum transferrin receptor / ferritin index, with a cut-off level of 1.5.
|
28421565 |
2017 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
The usefulness of reticulocyte haemoglobin content, serum transferrin receptor and the sTfR-ferritin index to identify iron deficiency in healthy children aged 1-16 years.
|
30264352 |
2019 |
|
Iron deficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results, which show the role of HIF-1 in the control of TfR gene expression in conditions of iron depletion, give insights into the mechanisms of transcriptional regulation which concur with the well-characterized post-transcriptional control of TfR expression to expand the extent of response to iron deficiency.
|
10518614 |
1999 |
|
Iron deficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To determine the potential role for TfR2 in iron uptake by liver, we investigated TfR and TfR2 expression in normal mice and murine models of dietary iron overload (2% carbonyl iron), dietary iron deficiency (gastric parietal cell ablation), and HH (HFE -/-).
|
10681454 |
2000 |
|
Iron deficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
2 and 6 μm ELT increased Tfr1 and Slc11a2 (iron-responsive genes involved in neuronal iron uptake) mRNA levels, indicating neuronal ID.
|
28005311 |
2017 |