TFRC, transferrin receptor, 7037

N. diseases: 359; N. variants: 40
Disease: Iron deficiency ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0240066
Disease: Iron deficiency
Iron deficiency 		0.100 AlteredExpression disease BEFREE Erythro-myeloid progenitors expressed less transferrin-receptor on the cell surface and had less labile iron compared to primitive erythroid progenitors, which could reduce their capacity to compete for scarce iron and survive iron deficiency. 31015568 2019
CUI: C0240066
Disease: Iron deficiency
Iron deficiency 		0.100 AlteredExpression disease BEFREE In addition, Co(2)Tf and Mn(2)Tf upregulated TFR1, reduced ferritin, and increased hypoxia-inducible factor-1alpha protein expression, suggesting that TFR1 upregulation was due to a combination of iron deficiency and chemical hypoxia. 19828835 2009
CUI: C0240066
Disease: Iron deficiency
Iron deficiency 		0.100 AlteredExpression disease BEFREE IRP2 inhibition by cisplatin caused ferritin upregulation and TfR1 downregulation leading to sustained intracellular iron deficiency. 30449675 2019