|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, induction of more severe iron deficiency in human trophoblast in vitro resulted in the regulation of both TFR1 and FPN, similar to what was observed in the mouse model.
|
31661462 |
2020 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
In children with anaemia, rates of iron deficiency (low ferritin based on inflammation status, and/or high soluble transferrin receptor, ≥1.97 mg/L) and zinc deficiency (serum zinc <65 μg/dl) were 81.1% and 53.7%, respectively.
|
31595712 |
2020 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study is aimed at investigating ID with conventional (ferritin, transferrin saturation [TSAT]) and new biomarkers (soluble transferrin receptor [sTfR], sTfR/log ferritin, reticulocyte hemoglobin content [CHr], hepcidin-25) in patients sub-grouped by the presence or absence of H. pylori infection.
|
31154451 |
2019 |
|
Iron deficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Erythro-myeloid progenitors expressed less transferrin-receptor on the cell surface and had less labile iron compared to primitive erythroid progenitors, which could reduce their capacity to compete for scarce iron and survive iron deficiency.
|
31015568 |
2019 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Soluble transferrin receptor/log ferritin index was significantly higher in iron deficiency anemia (median: 1.76) than in anemia of chronic disease (median: 0.55), anemia of chronic disease with iron deficiency (median: 0.68) or patients without anemia (median: 0.72).
|
30538074 |
2019 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum ferritin, soluble transferrin receptor, and total body iron for the detection of iron deficiency in early pregnancy: a multiethnic population-based study with low use of iron supplements.
|
30831600 |
2019 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we evaluated potential associations of tryptophan, kynurenine, and kynurenic acid with indicators of iron metabolism (i.e., mean corpuscular volume, mean corpuscular haemoglobin, ferritin, transferrin saturation, serum iron, transferrin, soluble transferrin receptor, reticulocyte haemoglobin) and haemoglobin in 430 individuals grouped by the presence or absence of iron deficiency or anaemia.
|
31601941 |
2019 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
From a cohort of children (n = 820), 4-8 years of age participating in a randomized controlled trial of pro-vitamin A, we estimated attributable fractions for anemia (hemoglobin of <110 or 115 g/L, by age) owing to current malaria or inflammation (C-reactive protein of >5 mg/L, or α-1 acid glycoprotein of >1 g/L, or both), and current or prior iron deficiency (ID; defined as low ferritin [<12 or 15 μg/L for age <5 or >5 years] or functional ID [soluble transferrin receptor of >8.3 mg/L] or both) and vitamin A deficiency (retinol of <0.7 μmol/L), during low and high malaria seasons, using multivariate logistic regression.
|
31402145 |
2019 |
|
Iron deficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IRP2 inhibition by cisplatin caused ferritin upregulation and TfR1 downregulation leading to sustained intracellular iron deficiency.
|
30449675 |
2019 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
The usefulness of reticulocyte haemoglobin content, serum transferrin receptor and the sTfR-ferritin index to identify iron deficiency in healthy children aged 1-16 years.
|
30264352 |
2019 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Malaria exacerbates inflammation-associated elevation in ferritin and soluble transferrin receptor with only modest effects on iron deficiency and iron deficiency anaemia among rural Zambian children.
|
29121448 |
2018 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Soluble transferrin receptor may be a reliable marker of ID in HIV-mediated inflammation.
|
29943722 |
2018 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Iron deficiency was identified with transferrin receptor in archived dried blood spots (TfR > 5.0 mg/l).
|
28832929 |
2017 |
|
Iron deficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
2 and 6 μm ELT increased Tfr1 and Slc11a2 (iron-responsive genes involved in neuronal iron uptake) mRNA levels, indicating neuronal ID.
|
28005311 |
2017 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Iron depletion (serum ferritin <15ug/ml) occurred in 19.2% and cellular iron deficiency (low serum ferritin and transferrin receptor >28.1 nmol/l) in 11.6% students.
|
29155855 |
2017 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Iron deficiency prevalence (inflammation-corrected ferritin <15 μg/L or soluble transferrin receptor >8.3 mg/L) was 67%; anemia was 36%, and vitamin D insufficiency (25(OH)D <30 ng/mL) was 77%.
|
28700535 |
2017 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
A positive association between ferroportin and TFRC mRNA, a gene associated with intracellular iron deficiency, was observed only in granulosa cells from fertile women.
|
27842994 |
2017 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Background:</b> Total-body iron stores (TBI), which are calculated from serum ferritin and soluble transferrin receptor concentrations, can be used to assess the iron status of populations in the United States.<b>Objective:</b> This analysis, developed to support workshop discussions, describes the distribution of TBI and the prevalence of iron deficiency (ID) and ID anemia (IDA) among toddlers, nonpregnant females, and pregnant females.<b>Design:</b> We analyzed data from NHANES; toddlers aged 12-23 mo (NHANES 2003-2010), nonpregnant females aged 15-49 y (NHANES 2007-2010), and pregnant females aged 12-49 y (NHANES 1999-2010).
|
29070559 |
2017 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Iron deficiency was quantifies as the serum transferrin receptor / ferritin index, with a cut-off level of 1.5.
|
28421565 |
2017 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Soluble transferrin receptor (sTfR) is a cleaved monomer of transferrin receptor 1 and correlates positively with tissue iron deficiency as well as with stimulated erythropoiesis.
|
26522463 |
2015 |
|
Iron deficiency
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Erythrocytic Iron Deficiency Enhances Susceptibility to Plasmodium chabaudi Infection in Mice Carrying a Missense Mutation in Transferrin Receptor 1.
|
26303393 |
2015 |
|
Iron deficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, Co(2)Tf and Mn(2)Tf upregulated TFR1, reduced ferritin, and increased hypoxia-inducible factor-1alpha protein expression, suggesting that TFR1 upregulation was due to a combination of iron deficiency and chemical hypoxia.
|
19828835 |
2009 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
TfR1 was localized in the crypts in controls but also in the villi with iron deficiency.
|
15054143 |
2004 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
The soluble transferrin receptor is a truncated form of the cellular transferrin receptor and the possible value of this measurement in the diagnosis of iron deficiency will be discussed.
|
14633776 |
2003 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression of the putative stimulator of Fe transport and TfR increases in iron deficiency.
|
11313310 |
2001 |