|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
On the other hand, TGF-β1 is increased in the lungs of individuals with asthma and may modulate airway inflammation.
|
28284979 |
2017 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, the results suggested that TGF-β1 enhances ADAM33 expression in airway epithelial cells, and that ADAM33 induces the EMT of airway epithelial cells, thus participating in airway remodeling in asthma.
|
29399106 |
2018 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
To evaluate main effects and gene-gene interactions of haplotype tagging single nucleotide polymorphisms of genes involved in regulatory T-cell function-IL6, IL6R, IL10, heme-oxygenase 1 (HMOX1), IL2, Toll-like receptor 2 (TLR2), TGFB1, TGF-beta receptor (TGFBR)-1, TGFBR2, IL2RA, and forkhead box protein 3 (FOXP3)-in relation to atopy and asthma.
|
20599261 |
2010 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
We investigated the interactive effects of 11 innate immunity-related genes (IL10, IL12b, IL8, TLR2, TLR4, CD14, IFNGR, CC16, IFNg, CMA1, and TGFB) and four IgE response genes (IL4, IL13, IL4RA, and STAT6) with 'Western' or 'Eastern' environments/lifestyles on asthma and allergy in Karelian children.
|
21749458 |
2011 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
TGF-β1 is an important cytokine in airway remodeling in asthma.
|
27905842 |
2017 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Controversy surrounding the increased expression of TGF beta 1 in asthma.
|
17892594 |
2007 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The transforming growth factor β1 (TGFB1) polymorphism -509C>T also modified the association of pollutants with asthma.
|
24243740 |
2014 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Here, we assessed whether TGF-β1 affects the ability of HASM cells to relax in response to β<sub>2</sub>-agonists, a mainstay treatment for airway hyperresponsiveness in asthma.
|
30742476 |
2019 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A meta-analysis was performed to investigate the association between polymorphisms in the TGF-beta1 gene and asthma susceptibility.
|
20409029 |
2010 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these results demonstrate that SIRT7 is involved in regulating TGF-β1-induced ASM cell proliferation and migration by regulating the expression of TβRI, thus indicating an important role of SIRT7 during airway remodeling in asthma.
|
29843083 |
2018 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Rhinovirus replication and virus release into supernatants were enhanced in fibroblasts incubated with TGF-beta1 and in fibroblasts obtained from patients with asthma.
|
19168696 |
2009 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, a novel 3-locus haplotype, 23_G_T, was found to be significantly associated with asthma (P = .00001 in cohorts A and B) as well as with higher serum TGF-beta1 level (P = .01).
|
15753900 |
2005 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in TNFα, TGFB1, PTGS1 and PTGS2 genes are associated with diisocyanate-induced asthma.
|
25721048 |
2016 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We tested TGF-beta1 single-nucleotide polymorphisms (SNPs) at position +869 of codon 10 (leucine or proline) and position +915 of codon 25 (arginine or proline) for association with irreversible bronchoconstriction in a case-control study involving 110 patients with asthma and 109 controls.
|
19046298 |
2008 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
As to T869C polymorphism (TGF-beta1), there was an association between the CC genotype and patients with severe asthma.
|
18425216 |
2008 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Altered pattern of monocyte differentiation and monocyte-derived TGF-β1 in severe asthma.
|
29343695 |
2018 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Associations between TGF-β and eosinophils will be addressed and the effects of genetic polymorphisms of the TGF-β1 gene explored in the context of asthma.
|
25240764 |
2014 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our results indicate that the polymorphisms at C-509T and T869C of the TGF-beta(1) gene are associated with asthma susceptibility in atopic subjects of the Hong Kong Chinese population, and the C-509T polymorphism may play a role in the pathogenesis of airflow obstruction.
|
16387590 |
2006 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The TGFbeta1-509C>T polymorphism was not significantly associated with the AIA phenotype; however, a significant association with the prevalence of rhinosinusitis in AIA (P=0.012), but not in ATA (P>0.05), was observed.
|
16916603 |
2007 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In T cells only patients with moderate asthma showed increased activin A mRNA expression, whereas TGF-beta(1) expression was equal to that seen in healthy subjects.
|
16387593 |
2006 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The three cytokine genes involved are interleukin (IL)-4, IL-9 and transforming growth factor beta1, and the nature of the polymorphisms may be related to significantly higher outputs of these cytokines in atopy and asthma.
|
10224407 |
1999 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Excessive production of TGF-beta(1) plays a key role in the tissue remodeling or fibrotic process observed in bronchial asthma, chronic pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF).
|
19393328 |
2009 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
We hypothesized that TGF-beta1 (innate response factor associated with wound repair) in combination with IL-13 (Th2 factor) might augment inflammatory processes associated with asthma.
|
12370400 |
2002 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The functional TGFβ1 promoter SNP C-509 associates with renal fibrosis and asthma.
|
26656423 |
2015 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Primary human bronchial fibroblasts (HBFs) propagated from ex vivo bronchial biopsies derived from patients with diagnosed asthma and human embryonic lung IMR-90 fibroblasts were cultured in vitro and treated with TGF-β1 and apigenin.
|
23563034 |
2013 |