|
Asthma
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Asthma model was induced using ovalbumin (OVA) method and AMSC hyperplasia model was induced using TGF-β1.
|
31733831 |
2020 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Transforming growth factor-beta1 (TGF-beta1) plays a pivotal role in increasing airway smooth muscle mass in severe asthma by inducing proliferation and hypertrophy of human airway smooth muscle.
|
17369289 |
2007 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Transforming growth factor beta 1 (TGF-beta1) is a major participant in the airway remodeling of asthma, a component of cellular stress response pathways, and enhanced epithelial immunoreactivity is known to occur in allergic rhinitis.
|
21819759 |
2011 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Transforming growth factor-β(1) (TGF-β(1)) is upregulated in asthma and COPD and contributes to tissue remodeling in the airways by driving ECM production by structural cells, including airway smooth muscle.
|
21908588 |
2011 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
TGF-β1 activation was also greater in children with severe asthma and was associated with higher airway 8-isoprostane, malondialdehyde, and IL-13 concentrations.
|
22206775 |
2012 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
TGF-β1 is an important cytokine in airway remodeling in asthma.
|
27905842 |
2017 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A meta-analysis was performed to investigate the association between polymorphisms in the TGF-beta1 gene and asthma susceptibility.
|
20409029 |
2010 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A polymorphism of a promoter region of TGFB1, C-509T, might be associated with the development of asthma, but its pathophysiologic relevance remains poorly understood.
|
18036644 |
2008 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
A total of 58 asthmatic patients (33 with severe refractory asthma (SRA)) and 10 healthy controls underwent sputum induction for % cells, activin A, follistatin, eosinophilic cationic protein (ECP), transforming growth factor beta 1 (TGF-β1), IL-13 and IL-8 measurements.
|
27807906 |
2017 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
CTD_human |
Abnormal expression of TGF-beta1 is believed to play an important role in the pathogenesis of a number of chronic inflammatory and immune lung diseases, including asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis.
|
16365456 |
2006 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
LHGDN |
Activation of TGF-beta/Smad2 signaling is associated with airway remodeling in asthma.
|
12170265 |
2002 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Altered pattern of monocyte differentiation and monocyte-derived TGF-β1 in severe asthma.
|
29343695 |
2018 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Among elderly asthmatics, subjects with severe asthma had lower FEV1 (% predicted) value, but showed significantly higher serum levels of eotaxin-2 and TGF-β1, than those with non-severe asthma (<i>P</i> < 0.05 for each).
|
30479079 |
2019 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Analysis of IL-13-dependent response using protein interaction networks highlights a role for TGF-beta1 as a key regulator of asthma.
|
17921359 |
2008 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
As to T869C polymorphism (TGF-beta1), there was an association between the CC genotype and patients with severe asthma.
|
18425216 |
2008 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
CTD_human |
Association between a TGFbeta1 promoter polymorphism and the phenotype of aspirin-intolerant chronic urticaria in a Korean population.
|
19138248 |
2008 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Associations between TGF-β and eosinophils will be addressed and the effects of genetic polymorphisms of the TGF-β1 gene explored in the context of asthma.
|
25240764 |
2014 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Collectively, these findings highlight a role for SIT enhancing host defense against bacteria depending on TGF-β1-induced CYP27B1in asthma.
|
28978148 |
2017 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Controversy surrounding the increased expression of TGF beta 1 in asthma.
|
17892594 |
2007 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Cryptotanshinone Attenuates Airway Remodeling by Inhibiting Crosstalk Between Tumor Necrosis Factor-Like Weak Inducer of Apoptosis and Transforming Growth Factor Beta 1 Signaling Pathways in Asthma.
|
31780948 |
2019 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Eosinophil-associated TGF-beta1 mRNA expression and airways fibrosis in bronchial asthma.
|
9308919 |
1997 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Eosinophils enhance WNT-5a and TGF-β1 genes expression in airway smooth muscle cells and promote their proliferation by increased extracellular matrix proteins production in asthma.
|
27297409 |
2016 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Eosinophils may play an important role in the pathogenesis of airway remodeling in asthma through the production of various fibrogenic cytokines such as transforming growth factor-beta1 (TGF-beta1).
|
15947480 |
2005 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Excessive production of TGF-beta(1) plays a key role in the tissue remodeling or fibrotic process observed in bronchial asthma, chronic pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF).
|
19393328 |
2009 |