|
Asthma
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
These results indicated that TGF beta 1 mRNA was overexpressed in severe asthmatics and that the main source of the mRNA was eosinophils, suggesting that eosinophils play an important role in the pathogenesis not only of inflammation but also of structural changes, such as subepithelial fibrosis, in asthmatic airways.
|
8810646 |
1996 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Eosinophil-associated TGF-beta1 mRNA expression and airways fibrosis in bronchial asthma.
|
9308919 |
1997 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The three cytokine genes involved are interleukin (IL)-4, IL-9 and transforming growth factor beta1, and the nature of the polymorphisms may be related to significantly higher outputs of these cytokines in atopy and asthma.
|
10224407 |
1999 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Therefore, TGFbeta1 is a promising candidate gene for contributing to asthma severity.
|
11810274 |
2001 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
LHGDN |
Activation of TGF-beta/Smad2 signaling is associated with airway remodeling in asthma.
|
12170265 |
2002 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
We hypothesized that TGF-beta1 (innate response factor associated with wound repair) in combination with IL-13 (Th2 factor) might augment inflammatory processes associated with asthma.
|
12370400 |
2002 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the T allele of C-509T is associated with the diagnosis of asthma and may enhance TGF-beta1 gene transcription.
|
14597484 |
2004 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The frequencies of the genotype associated with low production of TGF-beta1 were 14% versus 1% in infants with and without a parental history of asthma, respectively (p < 0.01).
|
15120189 |
2004 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, a novel 3-locus haplotype, 23_G_T, was found to be significantly associated with asthma (P = .00001 in cohorts A and B) as well as with higher serum TGF-beta1 level (P = .01).
|
15753900 |
2005 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The present study investigated two polymorphisms within the gene coding for TGF-beta1, -C509T and G915C, and for their potential association with bronchial asthma in Caucasian children.
|
15943594 |
2005 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Eosinophils may play an important role in the pathogenesis of airway remodeling in asthma through the production of various fibrogenic cytokines such as transforming growth factor-beta1 (TGF-beta1).
|
15947480 |
2005 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Potential anti-mRNA drugs in asthma and other allergic disorders may be targeted to cell surface receptors (adenosine A1 receptor, high-affinity receptor Fc-epsilon RI-alpha, cytokine receptors), adhesion molecules and ligands (ICAM-1, VLA-4), ion channels (calcium-dependent chloride channel-1), cytokines and related factors (IL-4, IL-5, IL-13, SCF, TNF-alpha, TGF-beta1), intracellular signal transduction molecules, such as tyrosine-protein kinases (Syk, Lyn, Btk), serine/ threonine-protein kinases (p38 alpha MAPkinase, Raf-1), non-kinase signaling proteins (RasGRP4), and transcription factors involved in Th2 differentiation and allergic inflammation (STAT-6, GATA-3, NF-kappaB).
|
16364194 |
2006 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
CTD_human |
Abnormal expression of TGF-beta1 is believed to play an important role in the pathogenesis of a number of chronic inflammatory and immune lung diseases, including asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis.
|
16365456 |
2006 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our results indicate that the polymorphisms at C-509T and T869C of the TGF-beta(1) gene are associated with asthma susceptibility in atopic subjects of the Hong Kong Chinese population, and the C-509T polymorphism may play a role in the pathogenesis of airflow obstruction.
|
16387590 |
2006 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In T cells only patients with moderate asthma showed increased activin A mRNA expression, whereas TGF-beta(1) expression was equal to that seen in healthy subjects.
|
16387593 |
2006 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
LHGDN |
These data suggest that NE upregulates TGF-beta1 gene expression and release via My88/IRAK/NF-kappaB pathway, possibly through activation of TLR4, and shed light on a potential role of neutrophils in the pathogenesis of asthma.
|
16690986 |
2006 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The TGFbeta1-509C>T polymorphism was not significantly associated with the AIA phenotype; however, a significant association with the prevalence of rhinosinusitis in AIA (P=0.012), but not in ATA (P>0.05), was observed.
|
16916603 |
2007 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
We examined TGFB1 SNPs in relation to asthma risk and degree of atopy among 546 case-parent triads, consisting of asthmatics aged 4-17 years and their parents in Mexico City.
|
17333284 |
2007 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
We examined TGFB1 SNPs in relation to asthma risk and degree of atopy among 546 case-parent triads, consisting of asthmatics aged 4-17 years and their parents in Mexico City.
|
17333284 |
2007 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Transforming growth factor-beta1 (TGF-beta1) plays a pivotal role in increasing airway smooth muscle mass in severe asthma by inducing proliferation and hypertrophy of human airway smooth muscle.
|
17369289 |
2007 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
LHGDN |
This is the first report to suggest a functional role for Nox4 in cell cycle transition and to demonstrate that Nox4 influences the pathobiochemistry of asthma by generating reactive oxygen species that promote TGF-beta1-induced proliferation and hypertrophy of human airway smooth muscle.
|
17369289 |
2007 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
TGF-beta(2) expression was observed in both the normal and asthmatic bronchial epithelium, and both real-time PCR and an ELISA showed a significant basal and TGF-beta(1)-induced TGF-beta(2) expression in the bronchial epithelial cell line BEAS2B.
|
17651146 |
2007 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
We hypothesized that the effects of functional TGF-beta1 variants on asthma occurrence vary by these exposures.
|
17673695 |
2007 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We hypothesized that the effects of functional TGF-beta1 variants on asthma occurrence vary by these exposures.
|
17673695 |
2007 |