|
Fibrosis
|
0.600 |
GeneticVariation
|
phenotype |
LHGDN |
These findings support the hypothesis that angiotensin II stimulated TGF-beta1 production may promote hepatic fibrosis.
|
14642613 |
2003 |
|
Fibrosis
|
0.600 |
AlteredExpression
|
phenotype |
LHGDN |
TGF-beta1 expression in renal allograft rejection and cyclosporine A toxicity.
|
16378061 |
2005 |
|
Fibrosis
|
0.600 |
Biomarker
|
phenotype |
LHGDN |
Differential role of TGF-beta1/bFGF and ET-1 in graft fibrosis in heart failure patients.
|
16095497 |
2005 |
|
Fibrosis
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
Curcumin prevents and reverses cirrhosis induced by bile duct obstruction or CCl4 in rats: role of TGF-beta modulation and oxidative stress.
|
18705752 |
2008 |
|
Fibrosis
|
0.600 |
GeneticVariation
|
phenotype |
LHGDN |
Fibrogenic polymorphisms (TGF-beta, PAI-1, AT) in Mexican patients with established liver fibrosis. Potential correlation with pirfenidone treatment.
|
18797412 |
2008 |
|
Fibrosis
|
0.600 |
AlteredExpression
|
phenotype |
LHGDN |
Cytokine production associated with periportal fibrosis during chronic schistosomiasis mansoni in humans.
|
16428771 |
2006 |
|
Fibrosis
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
Genes involved in innate immunity associated with asbestos-related fibrotic changes.
|
24142982 |
2014 |
|
Fibrosis
|
0.600 |
AlteredExpression
|
phenotype |
LHGDN |
In contrast, the TGF-beta1 vector caused a more severe and prolonged inflammatory response as well as localized collagen deposition, leading to severe and progressive fibrosis.
|
15778431 |
2005 |
|
Fibrosis
|
0.600 |
AlteredExpression
|
phenotype |
LHGDN |
These results suggest that TGF-beta(1) and PDGF expressions in bronchial mucosa may play a role in bronchial subepithelial fibrosis in EB patients.
|
14720431 |
2003 |
|
Fibrosis
|
0.600 |
Biomarker
|
phenotype |
LHGDN |
We conclude that TGF-beta1 concentration may predict the development of kidney graft fibrosis; early CsA withdrawal may achieve a reduction in chronic tubular and interstitial injury of cadaveric kidney allografts.
|
15848527 |
2005 |
|
Fibrosis
|
0.600 |
Biomarker
|
phenotype |
LHGDN |
The TGFbeta1-induced fibronectin in human renal proximal tubular epithelial cells is p38 MAP kinase dependent and Smad independent.
|
17347580 |
2007 |
|
Fibrosis
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
Modelling cardiac fibrosis using three-dimensional cardiac microtissues derived from human embryonic stem cells.
|
30809271 |
2019 |
|
Fibrosis
|
0.600 |
Biomarker
|
phenotype |
LHGDN |
Transforming growth factor-beta1 (TGF-beta1) is generally considered to be the major or predominant isoform involved in fibrosis, with the roles of TGF-beta2 and -beta3 being less clear.
|
12911534 |
2003 |
|
Fibrosis
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
Aspidin PB, a novel natural anti-fibrotic compound, inhibited fibrogenesis in TGF-β1-stimulated keloid fibroblasts via PI-3K/Akt and Smad signaling pathways.
|
26054450 |
2015 |
|
Fibrosis
|
0.600 |
Biomarker
|
phenotype |
RGD |
Customized platelet-rich plasma with transforming growth factor β1 neutralization antibody to reduce fibrosis in skeletal muscle.
|
26923362 |
2016 |
|
Fibrosis
|
0.600 |
Biomarker
|
phenotype |
LHGDN |
Histological, immunohistochemical and biological data in assessing interstitial fibrosis in patients with chronic glomerulonephritis.
|
18155753 |
2008 |
|
Fibrosis
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
Cardiomyocyte cell cycle activation ameliorates fibrosis in the atrium.
|
16306446 |
2006 |
|
Fibrosis
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
We show that local and transient TGF-beta1 overexpression induces homogenous, prolonged, and progressive pleural fibrosis without pleurodesis, associated with severe impairment of pulmonary function.
|
17947678 |
2007 |
|
Fibrosis
|
0.600 |
AlteredExpression
|
phenotype |
LHGDN |
Increased tubular C5b-9 expression may result in interstitial fibrosis through increased TGF-beta1 production.
|
18300128 |
2008 |
|
Fibrosis
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
Galectin-3 contributes to vascular fibrosis in monocrotaline-induced pulmonary arterial hypertension rat model.
|
27870162 |
2017 |
|
Fibrosis
|
0.600 |
GeneticVariation
|
phenotype |
LHGDN |
Transforming growth factor beta 1 gene variants increase transcription and are associated with liver cirrhosis in Chinese.
|
18547814 |
2008 |
|
Fibrosis
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
In conclusion, this strongly suggests that TGF-beta1 derived from tubular epithelial cells and some macrophages might be related to the development of renal interstitial fibrosis in HgCl2-treated BN rats.
|
10469268 |
1999 |
|
Fibrosis
|
0.600 |
AlteredExpression
|
phenotype |
LHGDN |
TGF-beta(1) expression was significantly correlated with both hepatic fibrosis and the percentage of portal tracts showing histological abnormalities associated with CFLD.
|
12000722 |
2002 |
|
Fibrosis
|
0.600 |
AlteredExpression
|
phenotype |
LHGDN |
In conclusion, an ongoing inflammatory process, the expression of TGF-beta 1, and proliferation of myofibroblasts within the valves have a potential role in the valvular fibrosis, calcification, and changes in the extracellular matrix that lead to the scarring sequelae of rheumatic heart disease.
|
18303197 |
2008 |
|
Fibrosis
|
0.600 |
AlteredExpression
|
phenotype |
LHGDN |
These results show, for the first time to our knowledge, that TGF-beta1 is highly expressed in HCs and is directly involved in the pathogenesis of BM reticulin fibrosis in HCL.
|
14991065 |
2004 |