Fibrosis
|
0.600 |
AlteredExpression
|
phenotype |
LHGDN |
TGF-beta(1) expression was significantly correlated with both hepatic fibrosis and the percentage of portal tracts showing histological abnormalities associated with CFLD.
|
12000722 |
2002 |
Fibrosis
|
0.600 |
Biomarker
|
phenotype |
LHGDN |
Transforming growth factor-beta1 (TGF-beta1) is generally considered to be the major or predominant isoform involved in fibrosis, with the roles of TGF-beta2 and -beta3 being less clear.
|
12911534 |
2003 |
Fibrosis
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
Aspidin PB, a novel natural anti-fibrotic compound, inhibited fibrogenesis in TGF-β1-stimulated keloid fibroblasts via PI-3K/Akt and Smad signaling pathways.
|
26054450 |
2015 |
Fibrosis
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
Cardiomyocyte cell cycle activation ameliorates fibrosis in the atrium.
|
16306446 |
2006 |
Fibrosis
|
0.600 |
GeneticVariation
|
phenotype |
LHGDN |
Contrarily, in Caucasians TGF-beta1 allelic variations are more frequent and the presence of prolines either in codon 25 or 10 is associated with the interindividual variability in developing more severe fibrosis during chronic hepatitis C infection.
|
15800982 |
2005 |
Fibrosis
|
0.600 |
AlteredExpression
|
phenotype |
LHGDN |
CTGF, intestinal stellate cells and carcinoid fibrogenesis.
|
17876891 |
2007 |
Fibrosis
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
Curcumin prevents and reverses cirrhosis induced by bile duct obstruction or CCl4 in rats: role of TGF-beta modulation and oxidative stress.
|
18705752 |
2008 |
Fibrosis
|
0.600 |
Biomarker
|
phenotype |
RGD |
Customized platelet-rich plasma with transforming growth factor β1 neutralization antibody to reduce fibrosis in skeletal muscle.
|
26923362 |
2016 |
Fibrosis
|
0.600 |
AlteredExpression
|
phenotype |
LHGDN |
Cytokine production associated with periportal fibrosis during chronic schistosomiasis mansoni in humans.
|
16428771 |
2006 |
Fibrosis
|
0.600 |
Biomarker
|
phenotype |
LHGDN |
Differential role of TGF-beta1/bFGF and ET-1 in graft fibrosis in heart failure patients.
|
16095497 |
2005 |
Fibrosis
|
0.600 |
GeneticVariation
|
phenotype |
LHGDN |
Fibrogenic polymorphisms (TGF-beta, PAI-1, AT) in Mexican patients with established liver fibrosis. Potential correlation with pirfenidone treatment.
|
18797412 |
2008 |
Fibrosis
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
Galectin-3 contributes to vascular fibrosis in monocrotaline-induced pulmonary arterial hypertension rat model.
|
27870162 |
2017 |
Fibrosis
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
Genes involved in innate immunity associated with asbestos-related fibrotic changes.
|
24142982 |
2014 |
Fibrosis
|
0.600 |
Biomarker
|
phenotype |
LHGDN |
Histological, immunohistochemical and biological data in assessing interstitial fibrosis in patients with chronic glomerulonephritis.
|
18155753 |
2008 |
Fibrosis
|
0.600 |
AlteredExpression
|
phenotype |
LHGDN |
In conclusion, an ongoing inflammatory process, the expression of TGF-beta 1, and proliferation of myofibroblasts within the valves have a potential role in the valvular fibrosis, calcification, and changes in the extracellular matrix that lead to the scarring sequelae of rheumatic heart disease.
|
18303197 |
2008 |
Fibrosis
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
In conclusion, this strongly suggests that TGF-beta1 derived from tubular epithelial cells and some macrophages might be related to the development of renal interstitial fibrosis in HgCl2-treated BN rats.
|
10469268 |
1999 |
Fibrosis
|
0.600 |
AlteredExpression
|
phenotype |
LHGDN |
In contrast, the TGF-beta1 vector caused a more severe and prolonged inflammatory response as well as localized collagen deposition, leading to severe and progressive fibrosis.
|
15778431 |
2005 |
Fibrosis
|
0.600 |
AlteredExpression
|
phenotype |
LHGDN |
Increased tubular C5b-9 expression may result in interstitial fibrosis through increased TGF-beta1 production.
|
18300128 |
2008 |
Fibrosis
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
Modelling cardiac fibrosis using three-dimensional cardiac microtissues derived from human embryonic stem cells.
|
30809271 |
2019 |
Fibrosis
|
0.600 |
AlteredExpression
|
phenotype |
LHGDN |
TGF-beta1 expression in renal allograft rejection and cyclosporine A toxicity.
|
16378061 |
2005 |
Fibrosis
|
0.600 |
Biomarker
|
phenotype |
LHGDN |
The TGFbeta1-induced fibronectin in human renal proximal tubular epithelial cells is p38 MAP kinase dependent and Smad independent.
|
17347580 |
2007 |
Fibrosis
|
0.600 |
GeneticVariation
|
phenotype |
LHGDN |
These findings support the hypothesis that angiotensin II stimulated TGF-beta1 production may promote hepatic fibrosis.
|
14642613 |
2003 |
Fibrosis
|
0.600 |
AlteredExpression
|
phenotype |
LHGDN |
These results show, for the first time to our knowledge, that TGF-beta1 is highly expressed in HCs and is directly involved in the pathogenesis of BM reticulin fibrosis in HCL.
|
14991065 |
2004 |
Fibrosis
|
0.600 |
AlteredExpression
|
phenotype |
LHGDN |
These results suggest that TGF-beta(1) and PDGF expressions in bronchial mucosa may play a role in bronchial subepithelial fibrosis in EB patients.
|
14720431 |
2003 |
Fibrosis
|
0.600 |
GeneticVariation
|
phenotype |
LHGDN |
Transforming growth factor beta 1 gene variants increase transcription and are associated with liver cirrhosis in Chinese.
|
18547814 |
2008 |