|
Adenomatous Polyposis Coli
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Co-transfection into SW480.7 cells of Smad4 together with a Ras phosphorylation-resistant Smad3 (but not with wild type Smad2, Smad3, adenomatous polyposis coli (APC), or TGF-beta type II receptor) restored the TGF-beta antiproliferative response.
|
10559252 |
1999 |
|
Adenosquamous carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study, the expression level of the important tumor suppressor, transforming growth factor beta type II receptor (TGFBR2), was examined both in LCC and non-LCC tumors, which include AdC, SqC and adenosquamous carcinoma (Ad-SqC).
|
17566598 |
2007 |
|
Adrenocortical carcinoma
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Reconstructing the TbetaRII can lead to reversion of the malignant phenotype of TbetaRII-negative human adrenocortical carcinoma, which contains SW-13 cells.
|
16673206 |
2006 |
|
Adrenocortical carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Reconstructing the TbetaRII can lead to reversion of the malignant phenotype of TbetaRII-negative human adrenocortical carcinoma, which contains SW-13 cells.
|
16673206 |
2006 |
|
Adult Burkitt Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Resistance to TGF-beta1 correlates with a reduction of TGF-beta type II receptor expression in Burkitt's lymphoma and Epstein-Barr virus-transformed B lymphoblastoid cell lines.
|
10811940 |
2000 |
|
Adult Cholangiocarcinoma
|
0.200 |
Biomarker
|
disease |
RGD |
In situ detection of TGF betas, TGF beta receptor II mRNA and telomerase activity in rat cholangiocarcinogenesis.
|
12632524 |
2003 |
|
Adult Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
ERBB3, IGF1R, and TGFBR2 expression correlate with PDGFR expression in glioblastoma and participate in PDGFR inhibitor resistance of glioblastoma cells.
|
29888103 |
2018 |
|
Adult Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Silencing of TbetaIIR abolished TGF-beta-induced glioblastoma invasiveness and migratory responses in vitro.
|
17684491 |
2008 |
|
Adult Hodgkin Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Materials and Methods In a dose escalation study, eight patients with Epstein Barr virus-positive Hodgkin lymphoma received two to 12 doses of between 2 × 10<sup>7</sup> and 1.5 × 10<sup>8</sup> cells/m<sup>2</sup> of DNRII-expressing T cells with specificity for the Epstein Barr virus-derived tumor antigens, latent membrane protein (LMP)-1 and LMP-2 (DNRII-LSTs).
|
29315015 |
2018 |
|
Adult Myelodysplastic Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Microsatellite instability is an early genetic event in myelodysplastic syndrome but is infrequent and not associated with TGF-beta receptor type II gene mutation.
|
8892669 |
1996 |
|
Age related macular degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
While retinal vasculature was unaffected, TGFBR2-deficient microglia demonstrated exaggerated responses to laser-induced injury that was associated with increased choroidal neovascularization, a hallmark of advanced exudative AMD.
|
30666961 |
2019 |
|
Agnosia
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Allergic rhinitis (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study demonstrated the first in the literature that lower miR-21 expression in CB and increased TGFBR2 expression is associated with antenatal IgE production and development of AR.
|
20701609 |
2010 |
|
Alveolar rhabdomyosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Using quantitative expression analysis in 16 ESFT and seven alveolar rhabdomyosarcomas (ARMS), we were able to validate the four genes previously described as direct targets of the EWSR1-FLI1 oncoprotein, showing overexpression of CAV1 and NR0B1 and underexpression of IGFBP3 and TGFBR2 in ESFT as compared to ARMS.
|
23185447 |
2012 |
|
Alzheimer disease, familial, type 3
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Although mutations in FBN1 and TGFBR1/TGFBR2 account for the majority of AD cases referred to us for molecular genetic testing, we have obtained negative results for these genes in a large cohort of AD patients, suggesting the involvement of additional genes or acquired factors.
|
20648054 |
2010 |
|
Alzheimer's Disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
We report that the TGF-beta type II receptor (TbetaRII) is mainly expressed by neurons, and that TbetaRII levels are reduced in human AD brain and correlate with pathological hallmarks of the disease.
|
17080199 |
2006 |
|
Alzheimer's Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Although mutations in FBN1 and TGFBR1/TGFBR2 account for the majority of AD cases referred to us for molecular genetic testing, we have obtained negative results for these genes in a large cohort of AD patients, suggesting the involvement of additional genes or acquired factors.
|
20648054 |
2010 |
|
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Among them, expression of AD-related genes (C4a/C4b, Cd74, Ctss, Gfap, Nfe2l2, Phyhd1, S100b, Tf, Tgfbr2, and Vim) was increased in the App <sup>NL-G-F/NL-G-F</sup> cortex as Aβ amyloidosis progressed with exacerbated gliosis, while genes commonly altered in the 3xTg-AD-H and human AD cortices correlated with neurological disease.
|
29259249 |
2017 |
|
Amaurosis Fugax
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Amyloidosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among them, expression of AD-related genes (C4a/C4b, Cd74, Ctss, Gfap, Nfe2l2, Phyhd1, S100b, Tf, Tgfbr2, and Vim) was increased in the App <sup>NL-G-F/NL-G-F</sup> cortex as Aβ amyloidosis progressed with exacerbated gliosis, while genes commonly altered in the 3xTg-AD-H and human AD cortices correlated with neurological disease.
|
29259249 |
2017 |
|
Anaplastic carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
A dominant negative mutation of transforming growth factor-beta receptor type II gene in microsatellite stable oesophageal carcinoma.
|
10789724 |
2000 |
|
Aneurysm
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Aneurysm
|
0.100 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
|
Aneurysm of aortic root
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
Arthrogryposis as neonatal presentation of Loeys-Dietz syndrome due to a novel TGFBR2 mutation.
|
28344185 |
2017 |
|
Aneurysm of aortic root
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|