|
Stomach Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
THBS4 is expressed on stromal cells with αSMA or Podoplanin expression in the GC microenvironment, but not expressed on cancer cells with cytokeratin expression.
|
31703077 |
2019 |
|
Tumor Cell Invasion
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Moreover, THBS4 overexpression fostered the migration and invasion of GC cells.
|
30746617 |
2019 |
|
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
THBS4 expression in cancer-associated fibroblasts (CAFs), normal-associated fibroblasts (NFs) and gastric cancer cell lines was examined by western blotting.
|
31703077 |
2019 |
|
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
The aim of this study was to study THBS4 expression in hepatocellular carcinoma (HCC) and determine if it was a prognostic marker for this malignancy.
|
30802535 |
2019 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Further, the bioinformatics analysis of the cancer genome atlas dataset suggested that there may be a positive correlation between THBS4 and KLF9 expression.
|
30746617 |
2019 |
|
Malignant neoplasm of stomach
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Expression levels of FGFR2 and TSP4 were detected by immunohistochemistry in GC tissue microarray slides.
|
30355943 |
2018 |
|
Stomach Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Expression levels of FGFR2 and TSP4 were detected by immunohistochemistry in GC tissue microarray slides.
|
30355943 |
2018 |
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
In vitro cell viability, colony formation, and invasion and migration assays were performed to evaluate the effect of FGFR2-TSP4 axis on tumor cell activities.
|
30355943 |
2018 |
|
Tumor Cell Invasion
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Overexpression of THBS4 was also highly correlated with vascular invasion of advanced HCC.
|
28177895 |
2017 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Thrombospondin-2 (THBS2) and Thrombospondin-4 (THBS4) play an important role in cancer development and progression.
|
27160021 |
2016 |
|
Malignant neoplasm of stomach
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to explore the association of THBS2/THBS4 polymorphisms with risk and clinicopathological features of GC in a Southeast Chinese population.
|
27160021 |
2016 |
|
Stomach Carcinoma
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to explore the association of THBS2/THBS4 polymorphisms with risk and clinicopathological features of GC in a Southeast Chinese population.
|
27160021 |
2016 |
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
The effects of forced THBS4 knockdown and lncRNA‑THBS4‑003 knockdown in the two PCa cell lines, DU145 and PC‑3, were evaluated using cell migration and invasion assays, as well as using Western blot analysis.
|
27357608 |
2016 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Thrombospondin-2 (THBS2) and Thrombospondin-4 (THBS4) play an important role in cancer development and progression.
|
27160021 |
2016 |
|
Coronary Artery Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The THBS2 3' untranslated region (UTR) polymorphism and THBS4 A387P polymorphism were not associated with overall CAD risk.
|
25976449 |
2015 |
|
Coronary Artery Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Thrombospondin-4 A387P polymorphism is not associated with coronary artery disease and myocardial infarction in the Chinese Han population.
|
14674882 |
2004 |
|
Coronary Artery Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
For the THBS-4 A387P polymorphism, additional studies are required to elucidate its role in premature CAD.
|
12482844 |
2002 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Our study was to explore the effects of THBS4 on GC progress and metastasis and the underlying mechanisms.
|
30746617 |
2019 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
THBS4 from CAFs is associated with the metastasis of cancer cells, and is a useful prognostic indicator for gastric cancer patients.
|
31703077 |
2019 |
|
Degenerative polyarthritis
|
0.020 |
Biomarker
|
disease |
BEFREE |
We were also able to detect pentameric and fragmented TSP-4 in the serum of both healthy controls and OA patients.
|
30669608 |
2019 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
THBS4 expression was higher in HCCs than in matched para-cancerous tissues (P < 0.001).
|
30802535 |
2019 |
|
Arteriosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Plasma proteomic analysis showed 13 proteins increased more than 1.3 fold in the SCI patients, including proteins involved in hypercoagulability (α2-antiplasmin, fibrinogen-γ chain, thrombospondin-4), inflammation (α2-macroglobulin, complement C1s and C3), and atherosclerosis (apolipoprotein B-100).
|
29545349 |
2018 |
|
Atherosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Plasma proteomic analysis showed 13 proteins increased more than 1.3 fold in the SCI patients, including proteins involved in hypercoagulability (α2-antiplasmin, fibrinogen-γ chain, thrombospondin-4), inflammation (α2-macroglobulin, complement C1s and C3), and atherosclerosis (apolipoprotein B-100).
|
29545349 |
2018 |
|
Hypertensive disease
|
0.020 |
Biomarker
|
group |
BEFREE |
In previous work, we studied the role of TSP-4 in small arteries during hypertension using Ang II-treated Thrombospondin 4 knockout (Thbs4<sup>-/-</sup>) mice.
|
29729633 |
2018 |
|
Degenerative polyarthritis
|
0.020 |
Biomarker
|
disease |
BEFREE |
We found strong evidence for the presence of IgG isotype autoantibodies against the cartilage extracellular matrix proteins TSP-4, COMP and CLEC3A in OA.
|
30001809 |
2018 |