|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Asthmatics had significantly lower circulating HPC expressing TLR-2 and TLR-9 with a similar trend for TLR-4.
|
28252235 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
TLR2 and CD14 SNPs were associated with asthma and atopic asthma respectively.
|
19096003 |
2009 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TLR2–16934A>T polymorphism could be a genetic predictor of AD severity, the coexistence of asthma or atopic conjunctivitis as well as a family history of atopic diseases, especially in subjects having higher TS IgE.
|
21134221 |
2011 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
B7-H3 participates in the development of Asthma by augmentation of the inflammatory response independent of TLR2 pathway.
|
28094276 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chlamydia pneumoniae induces interleukin-12 responses in peripheral blood mononuclear cells in asthma and the role of toll like receptor 2 versus 4: a pilot study.
|
28035483 |
2017 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Decreased Toll-like receptor 2 (TLR2) expression has been reported in patients with chronic obstructive pulmonary disease and in a murine asthma model, which may predispose the hosts to bacterial infections, leading to disease exacerbations.
|
21239529 |
2011 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Examples include variants of TLR4 in sepsis, malaria, inflammatory bowel disease and atherosclerosis; variants in TLR2 in tuberculosis and asthma; a variant in Mal (a key signal for TLR2 and TLR4) in malaria, tuberculosis and systemic lupus erythematosus; and variants in the kinase IRAK4 in pyogenic infections.
|
20375592 |
2009 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression of toll-like receptor (TLR) 2 subfamily genes, including genes encoding TLR1, TLR2, TLR6 and TLR10, have been connected to allergy and asthma.
|
24112285 |
2013 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Finally, TLR2 expression at the protein and mRNA levels was upregulated in cord blood basophils from neonates born to mothers with asthma following stimulation with PGN but not Df.
|
21438704 |
2011 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
HE staining showed that the infiltration degree of inflammatory cells in perivascular tissues in TLR2-/- asthma group was reduced compared with that in C57BL/6 asthma group.
|
29863259 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, recent results indicate that the TLR-2 → NLRP3 → caspase-1 → IL-18 axis is critical to H. pylori-specific immune regulation conferring protection against allergen-induced asthma and inflammatory bowel disease in murine models.
|
27460807 |
2016 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our study demonstrates a lack of association of TLR2 and TLR4 polymorphisms with asthma and allergic rhinitis but suggests significant association between these genetic variants and the disease severity.
|
22402138 |
2012 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interaction between ITGB3 SNPs and TLR2/+596, which was previously shown to be associated with asthma, was studied.
|
21570717 |
2011 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results indicate that a genetic variant in the TLR2 subfamily may play a role in susceptibility to asthma.
|
20815312 |
2010 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Our results suggest that genetic variation in TLR2 is a major determinant of the susceptibility to asthma and allergies in children of farmers.
|
15007351 |
2004 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that genetic variation in TLR2 is a major determinant of the susceptibility to asthma and allergies in children of farmers.
|
15007351 |
2004 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Resting and lipopolysaccharide (LPS)-stimulated circulating neutrophils had lower levels of TLR2 and IL-1beta gene expression in asthma, but were otherwise similar to healthy controls.
|
19842845 |
2009 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum IP-10 levels showed a significant negative correlation with age (p=0.009), TLR2 (p=0.05) and spirometric indices (p=0.002) in all asthmatics and a significant positive correlation with parameters of asthma attack severity (p=0.03) in acute asthma group.
|
27955890 |
2017 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Short-term exposure to A. fumigatus could down-regulate the expression of GCR, aggravate airway hyper-responsiveness and increase the level of TLR2 in rats with asthma.
|
28696809 |
2018 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Sputum TLR2 mRNA expression was up-regulated in both acute and stable asthma compared with healthy controls and decreased 4-6 weeks after acute exacerbation.
|
21129050 |
2011 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, these data implicated that ABCA1 suppressed PDGF-induced proliferation, migration, and contraction in rat ASMCs at least partly through TLR2/NF-κB/NFATc1 signaling, which might offer hope for the future treatment of airway remodeling in asthma.
|
29775222 |
2018 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The combined results show that rs3804099 in TLR2 and rs4986791 in TLR4 were significantly associated with asthma risk.
|
28858111 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This suggests a protective role for TLR2 activation and MMP-9 release in the context of experimentally induced asthma in mice.
|
19667087 |
2009 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TLR4 and TLR2 were reduced in total PBMC from asthmatics in comparison to PBMC from controls.
|
25722071 |
2015 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To evaluate main effects and gene-gene interactions of haplotype tagging single nucleotide polymorphisms of genes involved in regulatory T-cell function-IL6, IL6R, IL10, heme-oxygenase 1 (HMOX1), IL2, Toll-like receptor 2 (TLR2), TGFB1, TGF-beta receptor (TGFBR)-1, TGFBR2, IL2RA, and forkhead box protein 3 (FOXP3)-in relation to atopy and asthma.
|
20599261 |
2010 |